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Published in: Child's Nervous System 8-9/2005

01-08-2005 | Special Annual Issue

Endocrine manifestations of craniopharyngioma

Authors: Isil Halac, Donald Zimmerman

Published in: Child's Nervous System | Issue 8-9/2005

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Abstract

Rationale

Due to the proximity of craniopharyngiomas to the hypothalamus and pituitary gland, most children and adolescents presenting with these tumors will exhibit significant endocrine dysfunction. After treatment, these impairments can become a major cause of morbidity and mortality.

Methods

The postoperative course of children undergoing surgery for craniopharyngioma is reviewed.

Conclusion

Even if hormone levels seem to be adequate in the short term after treatment, deficiencies may develop over years and need to be monitored closely.
Literature
1.
go back to reference Chakrabarty A, Mitchell P, Bridges LR (1998) Craniopharyngioma invading the nasal and paranasal spaces, and presenting as nasal obstruction. Br J Neurosurg 12(4):361–363CrossRefPubMed Chakrabarty A, Mitchell P, Bridges LR (1998) Craniopharyngioma invading the nasal and paranasal spaces, and presenting as nasal obstruction. Br J Neurosurg 12(4):361–363CrossRefPubMed
2.
go back to reference Sklar CA (1994) Craniopharyngioma: endocrine abnormalities at presentation. Pediatr Neurosurg 21(Suppl 1):18–20PubMed Sklar CA (1994) Craniopharyngioma: endocrine abnormalities at presentation. Pediatr Neurosurg 21(Suppl 1):18–20PubMed
3.
go back to reference Robinson AG, Verbalis JG (2003) Posterior pituitary gland. In: Larsen PR, Kronenberg HM, Melmed S, Polonsky KS (eds) Williams textbook of endocrinology. Elsevier Science, Philadelphia, PA, pp 281–329 Robinson AG, Verbalis JG (2003) Posterior pituitary gland. In: Larsen PR, Kronenberg HM, Melmed S, Polonsky KS (eds) Williams textbook of endocrinology. Elsevier Science, Philadelphia, PA, pp 281–329
4.
go back to reference Banna M, Hoare RD, Stanley P, Till K (1973) Craniopharyngioma in children. J Pediatr 83(5):781–785PubMed Banna M, Hoare RD, Stanley P, Till K (1973) Craniopharyngioma in children. J Pediatr 83(5):781–785PubMed
5.
go back to reference de Vries L, Lazar L, Phillip M (2003) Craniopharyngioma: presentation and endocrine sequelae in 36 children. J Pediatr Endocrinol Metab 16(5):110–703PubMed de Vries L, Lazar L, Phillip M (2003) Craniopharyngioma: presentation and endocrine sequelae in 36 children. J Pediatr Endocrinol Metab 16(5):110–703PubMed
6.
go back to reference Thomsett MJ, Conte FA, Kaplan SL, Grumbach MM (1980) Endocrine and neurologic outcome in childhood craniopharyngioma: review of effect of treatment in 42 patients. J Pediatr 97(5):728–735PubMed Thomsett MJ, Conte FA, Kaplan SL, Grumbach MM (1980) Endocrine and neurologic outcome in childhood craniopharyngioma: review of effect of treatment in 42 patients. J Pediatr 97(5):728–735PubMed
7.
go back to reference Sorva R (1988) Children with craniopharyngioma. Early growth failure and rapid postoperative weight gain. Acta Paediatr Scand 77(4):587–592PubMed Sorva R (1988) Children with craniopharyngioma. Early growth failure and rapid postoperative weight gain. Acta Paediatr Scand 77(4):587–592PubMed
8.
go back to reference Wit JM, Schuitema-Dijkstra A, van Buul-Offers S, Opmeer F, Van den Brande JL (1988) Excessive growth in a child with craniopharyngioma and growth hormone deficiency. Eur J Pediatr 147(6):658–661CrossRefPubMed Wit JM, Schuitema-Dijkstra A, van Buul-Offers S, Opmeer F, Van den Brande JL (1988) Excessive growth in a child with craniopharyngioma and growth hormone deficiency. Eur J Pediatr 147(6):658–661CrossRefPubMed
9.
go back to reference Blethen SL, Weldon VV (1986) Outcome in children with normal growth following removal of a craniopharyngioma. Am J Med Sci 292(1):21–24PubMed Blethen SL, Weldon VV (1986) Outcome in children with normal growth following removal of a craniopharyngioma. Am J Med Sci 292(1):21–24PubMed
10.
go back to reference Weinzimer SA, Homan SA, Ferry RJ, Moshang T (1999) Serum IGF-I and IGFBP-3 concentrations do not accurately predict growth hormone deficiency in children with brain tumours. Clin Endocrinol (Oxf) 51(3):339–345CrossRef Weinzimer SA, Homan SA, Ferry RJ, Moshang T (1999) Serum IGF-I and IGFBP-3 concentrations do not accurately predict growth hormone deficiency in children with brain tumours. Clin Endocrinol (Oxf) 51(3):339–345CrossRef
11.
go back to reference Moshang T Jr, Rundle AC, Graves DA, Nickas J, Johanson A, Meadows A (1996) Brain tumor recurrence in children treated with growth hormone: the National Cooperative Growth Study experience. J Pediatr 128(5 Pt 2):S4–S7PubMed Moshang T Jr, Rundle AC, Graves DA, Nickas J, Johanson A, Meadows A (1996) Brain tumor recurrence in children treated with growth hormone: the National Cooperative Growth Study experience. J Pediatr 128(5 Pt 2):S4–S7PubMed
12.
go back to reference Wilton P, Price DA (1992) Rate of relapse of craniopharyngioma in children treated with growth hormone. KIGS Biannu Rep No 8 1:48–54 Wilton P, Price DA (1992) Rate of relapse of craniopharyngioma in children treated with growth hormone. KIGS Biannu Rep No 8 1:48–54
13.
go back to reference Niu DM, Guo WY, Pan HC, Wong TT (2002) Rapid enlargement of a residual craniopharyngioma during short-term growth hormone replacement. Childs Nerv Syst 18(3–4):164–165. Epub 2002 Mar 5CrossRefPubMed Niu DM, Guo WY, Pan HC, Wong TT (2002) Rapid enlargement of a residual craniopharyngioma during short-term growth hormone replacement. Childs Nerv Syst 18(3–4):164–165. Epub 2002 Mar 5CrossRefPubMed
14.
15.
go back to reference Lustig RH, Post SR, Srivannaboon K, Rose SR, Danish RK, Burghen GA, Xiong X, Wu S, Merchant TE (2003) Risk factors for the development of obesity in children surviving brain tumors. J Clin Endocrinol Metab 88(2):611–616CrossRefPubMed Lustig RH, Post SR, Srivannaboon K, Rose SR, Danish RK, Burghen GA, Xiong X, Wu S, Merchant TE (2003) Risk factors for the development of obesity in children surviving brain tumors. J Clin Endocrinol Metab 88(2):611–616CrossRefPubMed
16.
go back to reference Muller HL, Emser A, Faldum A, Bruhnken G, Etavard-Gorris N, Gebhardt U, Oeverink R, Kolb R, Sorensen N (2004) Longitudinal study on growth and body mass index before and after diagnosis of childhood craniopharyngioma. J Clin Endocrinol Metab 89(7):3298–3305CrossRefPubMed Muller HL, Emser A, Faldum A, Bruhnken G, Etavard-Gorris N, Gebhardt U, Oeverink R, Kolb R, Sorensen N (2004) Longitudinal study on growth and body mass index before and after diagnosis of childhood craniopharyngioma. J Clin Endocrinol Metab 89(7):3298–3305CrossRefPubMed
17.
go back to reference Attia N, Tamborlane WV, Heptulla R, Maggs D, Grozman A, Sherwin RS, Caprio S (1998) The metabolic syndrome and insulin-like growth factor I regulation in adolescent obesity. J Clin Endocrinol Metab 83(5):1467–1471CrossRefPubMed Attia N, Tamborlane WV, Heptulla R, Maggs D, Grozman A, Sherwin RS, Caprio S (1998) The metabolic syndrome and insulin-like growth factor I regulation in adolescent obesity. J Clin Endocrinol Metab 83(5):1467–1471CrossRefPubMed
18.
go back to reference Schoenle EJ, Zapf J, Prader A, Torresani T, Werder EA, Zachmann M (1995) Replacement of growth hormone (GH) in normally growing GH-deficient patients operated for craniopharyngioma. J Clin Endocrinol Metab 80(2):374–378CrossRefPubMed Schoenle EJ, Zapf J, Prader A, Torresani T, Werder EA, Zachmann M (1995) Replacement of growth hormone (GH) in normally growing GH-deficient patients operated for craniopharyngioma. J Clin Endocrinol Metab 80(2):374–378CrossRefPubMed
19.
go back to reference Pajas M, Lucas T, Garcia-Uria J, Salame F, Barcelo B, Estrada J (1995) Hypothalamic–pituitary dysfunction in patients with craniopharyngioma. Clin Endocrinol (Oxf) 42(5):467–473 Pajas M, Lucas T, Garcia-Uria J, Salame F, Barcelo B, Estrada J (1995) Hypothalamic–pituitary dysfunction in patients with craniopharyngioma. Clin Endocrinol (Oxf) 42(5):467–473
20.
go back to reference Clopper RR, Mazur T, MacGillivray MH, Peterson RE, Voorhess ML (1983) Data on virilization and erotosexual behavior in male hypogonadotropic hypopituitarism during gonadotropin and androgen treatment. J Androl 4(5):303–311PubMed Clopper RR, Mazur T, MacGillivray MH, Peterson RE, Voorhess ML (1983) Data on virilization and erotosexual behavior in male hypogonadotropic hypopituitarism during gonadotropin and androgen treatment. J Androl 4(5):303–311PubMed
21.
go back to reference Abbaticchio G, Micale FM, Giagulli VA, Giorgino R (1985) Recovery of fertility in a hypogonadotropic man apparently resistant to gonadotrophin treatment. Arch Androl 15(1):59–64PubMed Abbaticchio G, Micale FM, Giagulli VA, Giorgino R (1985) Recovery of fertility in a hypogonadotropic man apparently resistant to gonadotrophin treatment. Arch Androl 15(1):59–64PubMed
22.
go back to reference Volz J, Heinrich U, Volz-Koster S (2002) Conception and spontaneous delivery after total hypophysectomy. Fertil Steril 77(3):624–625CrossRefPubMed Volz J, Heinrich U, Volz-Koster S (2002) Conception and spontaneous delivery after total hypophysectomy. Fertil Steril 77(3):624–625CrossRefPubMed
23.
go back to reference Hayashi M, Tomobe K, Hoshimoto K, Ohkura T (2002) Successful pregnancy following gonadotropin therapy in a patient with hypogonadotropic hypogonadism resulting from craniopharyngioma. Int J Clin Pract 56(2):149–151PubMed Hayashi M, Tomobe K, Hoshimoto K, Ohkura T (2002) Successful pregnancy following gonadotropin therapy in a patient with hypogonadotropic hypogonadism resulting from craniopharyngioma. Int J Clin Pract 56(2):149–151PubMed
24.
go back to reference Zachmann M, Illig R (1979) Precocious puberty after surgery for craniopharyngioma. J Pediatr 95(1):86–88PubMed Zachmann M, Illig R (1979) Precocious puberty after surgery for craniopharyngioma. J Pediatr 95(1):86–88PubMed
25.
go back to reference Persani L, Ferretti E, Borgato S, Faglia G, Beck-Peccoz P (2000) Circulating thyrotropin bioactivity in sporadic central hypothyroidism. J Clin Endocrinol Metab 85(10):3631–3635CrossRefPubMed Persani L, Ferretti E, Borgato S, Faglia G, Beck-Peccoz P (2000) Circulating thyrotropin bioactivity in sporadic central hypothyroidism. J Clin Endocrinol Metab 85(10):3631–3635CrossRefPubMed
26.
go back to reference Gruneiro-Papendieck L, Chiesa A, Martinez A, Heinrich JJ, Bergada C (1998) Nocturnal TSH surge and TRH test response in the evaluation of thyroid axis in hypothalamic pituitary disorders in childhood. Horm Res 50(5):252–257CrossRefPubMed Gruneiro-Papendieck L, Chiesa A, Martinez A, Heinrich JJ, Bergada C (1998) Nocturnal TSH surge and TRH test response in the evaluation of thyroid axis in hypothalamic pituitary disorders in childhood. Horm Res 50(5):252–257CrossRefPubMed
27.
go back to reference Bin-Abbas B, Mawlawi H, Sakati N, Khafaja Y, Chaudhary MA, Al-Ashwal A (2001) Endocrine sequelae of childhood craniopharyngioma. J Pediatr Endocrinol Metab 14(7):869–874PubMed Bin-Abbas B, Mawlawi H, Sakati N, Khafaja Y, Chaudhary MA, Al-Ashwal A (2001) Endocrine sequelae of childhood craniopharyngioma. J Pediatr Endocrinol Metab 14(7):869–874PubMed
28.
go back to reference Isojarvi JI, Turkka J, Pakarinen AJ, Kotila M, Rattya J, Myllyla VV (2001) Thyroid function in men taking carbamazepine, oxcarbazepine, or valproate for epilepsy. Epilepsia 42(7):930–934CrossRefPubMed Isojarvi JI, Turkka J, Pakarinen AJ, Kotila M, Rattya J, Myllyla VV (2001) Thyroid function in men taking carbamazepine, oxcarbazepine, or valproate for epilepsy. Epilepsia 42(7):930–934CrossRefPubMed
29.
go back to reference Surks MI, DeFesi CR (1996) Normal serum free thyroid hormone concentrations in patients treated with phenytoin or carbamazepine. A paradox resolved. JAMA 275(19):1495–1498CrossRefPubMed Surks MI, DeFesi CR (1996) Normal serum free thyroid hormone concentrations in patients treated with phenytoin or carbamazepine. A paradox resolved. JAMA 275(19):1495–1498CrossRefPubMed
30.
go back to reference Lyen KR, Grant DB (1982) Endocrine function, morbidity, and mortality after surgery for craniopharyngioma. Arch Dis Child 57(11):837–841PubMed Lyen KR, Grant DB (1982) Endocrine function, morbidity, and mortality after surgery for craniopharyngioma. Arch Dis Child 57(11):837–841PubMed
31.
go back to reference Rose SR, Danish RK, Kearney NS, Schreiber RE, Lustig RH, Burghen GA, Hudson MM (2005) ACTH deficiency in childhood cancer survivors. Pediatr Blood Cancer, Feb 7 Rose SR, Danish RK, Kearney NS, Schreiber RE, Lustig RH, Burghen GA, Hudson MM (2005) ACTH deficiency in childhood cancer survivors. Pediatr Blood Cancer, Feb 7
32.
go back to reference Styne DM, Richards GE, Bell JJ et al (1977) Growth patterns in congenital adrenal hyperplasia: correlation of glucocorticoid therapy with stature. In: Lee P, Plotnick L, Kowarski A, Migeon C (eds) Congenital adrenal hyperplasia. University Park Press, Baltimore, pp 247–261 Styne DM, Richards GE, Bell JJ et al (1977) Growth patterns in congenital adrenal hyperplasia: correlation of glucocorticoid therapy with stature. In: Lee P, Plotnick L, Kowarski A, Migeon C (eds) Congenital adrenal hyperplasia. University Park Press, Baltimore, pp 247–261
33.
go back to reference Linder BL, Esteban NV, Yergey AL, Winterer JC, Loriaux DL, Cassorla F (1990) Cortisol production rate in childhood and adolescence. J Pediatr 117(6):892–896PubMed Linder BL, Esteban NV, Yergey AL, Winterer JC, Loriaux DL, Cassorla F (1990) Cortisol production rate in childhood and adolescence. J Pediatr 117(6):892–896PubMed
34.
go back to reference Kerrigan JR, Veldhuis JD, Leyo SA, Iranmanesh A, Rogol AD (1993) Estimation of daily cortisol production and clearance rates in normal pubertal males by deconvolution analysis. J Clin Endocrinol Metab 76(6):1505–1510CrossRefPubMed Kerrigan JR, Veldhuis JD, Leyo SA, Iranmanesh A, Rogol AD (1993) Estimation of daily cortisol production and clearance rates in normal pubertal males by deconvolution analysis. J Clin Endocrinol Metab 76(6):1505–1510CrossRefPubMed
35.
go back to reference Miller WL (2003) The adrenal cortex. In: Sperling MA (ed) Pediatric endocrinology. Elsevier Science, Philadelphia, PA pp 385–438 Miller WL (2003) The adrenal cortex. In: Sperling MA (ed) Pediatric endocrinology. Elsevier Science, Philadelphia, PA pp 385–438
36.
go back to reference Lehrnbecher T, Muller-Scholden J, Danhauser-Leistner I, Sorensen N, von Stockhausen HB (1998) Perioperative fluid and electrolyte management in children undergoing surgery for craniopharyngioma. A 10-year experience in a single institution. Childs Nerv Syst 14(6):276–279CrossRefPubMed Lehrnbecher T, Muller-Scholden J, Danhauser-Leistner I, Sorensen N, von Stockhausen HB (1998) Perioperative fluid and electrolyte management in children undergoing surgery for craniopharyngioma. A 10-year experience in a single institution. Childs Nerv Syst 14(6):276–279CrossRefPubMed
37.
go back to reference Gonzales-Portillo G, Tomita T (1998) The syndrome of inappropriate secretion of antidiuretic hormone: an unusual presentation for childhood craniopharyngioma: report of three cases. Neurosurgery 42(4):917–921; discussion 921–922CrossRefPubMed Gonzales-Portillo G, Tomita T (1998) The syndrome of inappropriate secretion of antidiuretic hormone: an unusual presentation for childhood craniopharyngioma: report of three cases. Neurosurgery 42(4):917–921; discussion 921–922CrossRefPubMed
38.
go back to reference Hetelekidis S, Barnes PD, Tao ML, Fischer EG, Schneider L, Scott RM, Tarbell NJ (1993) 20-year experience in childhood craniopharyngioma. Int J Radiat Oncol Biol Phys 27(2):189–195PubMed Hetelekidis S, Barnes PD, Tao ML, Fischer EG, Schneider L, Scott RM, Tarbell NJ (1993) 20-year experience in childhood craniopharyngioma. Int J Radiat Oncol Biol Phys 27(2):189–195PubMed
39.
go back to reference Jeanrenaud B (1985) An hypothesis on the aetiology of obesity: dysfunction of the central nervous system as a primary cause. Diabetologia 28(8):502–513 ReviewCrossRefPubMed Jeanrenaud B (1985) An hypothesis on the aetiology of obesity: dysfunction of the central nervous system as a primary cause. Diabetologia 28(8):502–513 ReviewCrossRefPubMed
40.
go back to reference Bray GA, York DA (1979) Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol Rev 59(3):719–809PubMed Bray GA, York DA (1979) Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol Rev 59(3):719–809PubMed
41.
go back to reference Smith DK, Sarfeh J, Howard L (1983) Truncal vagotomy in hypothalamic obesity. Lancet 1(8337):1330–1331CrossRefPubMed Smith DK, Sarfeh J, Howard L (1983) Truncal vagotomy in hypothalamic obesity. Lancet 1(8337):1330–1331CrossRefPubMed
42.
go back to reference Lustig RH, Rose SR, Burghen GA, Velasquez-Mieyer P, Broome DC, Smith K, Li H, Hudson MM, Heideman RL, Kun LE (1999) Hypothalamic obesity caused by cranial insult in children: altered glucose and insulin dynamics and reversal by a somatostatin agonist. J Pediatr 135(2 Pt 1):162–168PubMed Lustig RH, Rose SR, Burghen GA, Velasquez-Mieyer P, Broome DC, Smith K, Li H, Hudson MM, Heideman RL, Kun LE (1999) Hypothalamic obesity caused by cranial insult in children: altered glucose and insulin dynamics and reversal by a somatostatin agonist. J Pediatr 135(2 Pt 1):162–168PubMed
43.
go back to reference Mason PW, Krawiecki N, Meacham LR (2002) The use of dextroamphetamine to treat obesity and hyperphagia in children treated for craniopharyngioma. Arch Pediatr Adolesc Med 156(9):887–892PubMed Mason PW, Krawiecki N, Meacham LR (2002) The use of dextroamphetamine to treat obesity and hyperphagia in children treated for craniopharyngioma. Arch Pediatr Adolesc Med 156(9):887–892PubMed
44.
go back to reference Larijani B, Bastanhagh MH, Pajouhi M, Kargar Shadab F, Vasigh A, Aghakhani S (2004) Presentation and outcome of 93 cases of craniopharyngioma. Eur J Cancer Care (Engl) 13(1):11–15CrossRef Larijani B, Bastanhagh MH, Pajouhi M, Kargar Shadab F, Vasigh A, Aghakhani S (2004) Presentation and outcome of 93 cases of craniopharyngioma. Eur J Cancer Care (Engl) 13(1):11–15CrossRef
45.
go back to reference Sorva R, Heiskanen O, Perheentupa J (1988) Craniopharyngioma surgery in children: endocrine and visual outcome. Childs Nerv Syst 4(2):97–99PubMed Sorva R, Heiskanen O, Perheentupa J (1988) Craniopharyngioma surgery in children: endocrine and visual outcome. Childs Nerv Syst 4(2):97–99PubMed
46.
go back to reference Nakasu Y, Nakasu S, Handa J, Takeuchi J (1980) Amenorrhea–galactorrhea syndrome with craniopharyngioma. Surg Neurol 13(2):154–156PubMed Nakasu Y, Nakasu S, Handa J, Takeuchi J (1980) Amenorrhea–galactorrhea syndrome with craniopharyngioma. Surg Neurol 13(2):154–156PubMed
47.
go back to reference Muller HL, Handwerker G, Wollny B, Faldum A, Sorensen N (2002) Melatonin secretion and increased daytime sleepiness in childhood craniopharyngioma patients. J Clin Endocrinol Metab 87(8):3993–3996CrossRefPubMed Muller HL, Handwerker G, Wollny B, Faldum A, Sorensen N (2002) Melatonin secretion and increased daytime sleepiness in childhood craniopharyngioma patients. J Clin Endocrinol Metab 87(8):3993–3996CrossRefPubMed
48.
go back to reference Tomlinson JW, Holden N, Hills RK, Wheatley K, Clayton RN, Bates AS, Sheppard MC, Stewart PM (2001) Association between premature mortality and hypopituitarism. West midlands prospective hypopituitary study group. Lancet 357(9254):425–431CrossRefPubMed Tomlinson JW, Holden N, Hills RK, Wheatley K, Clayton RN, Bates AS, Sheppard MC, Stewart PM (2001) Association between premature mortality and hypopituitarism. West midlands prospective hypopituitary study group. Lancet 357(9254):425–431CrossRefPubMed
Metadata
Title
Endocrine manifestations of craniopharyngioma
Authors
Isil Halac
Donald Zimmerman
Publication date
01-08-2005
Publisher
Springer-Verlag
Published in
Child's Nervous System / Issue 8-9/2005
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-005-1246-x

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