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01-01-2008 | Brief Report

End-stage renal failure, reflux nephropathy and Feingold’s syndrome

Authors: Mona Aslam, Hans van Bokhoven, Christopher Mark Taylor

Published in: Pediatric Nephrology | Issue 1/2008

Abstract

Feingold’s syndrome is a recognised syndrome of organ maldevelopment. Renal abnormalities are not a consistent feature. We report the case of a girl with Feingold’s syndrome who had developed end-stage renal failure by the age of 6 years. We recommend that urinary tract imaging be carried out in all children suspected of having Feingold’s syndrome.

Celli J, van Beusekom E, Hennekam RC, Gallardo ME, Smeets DF, de Cordoba SR, Innis JW, Frydman M, Konig R, Kingston H, Tolmie J, Govaerts LC, van Bokhoven H, Brunner HG (2000) Familial syndromic esophageal atresia maps to 2p23–p24. Am J Hum Genet 66:436–444CrossRef

van Bokhoven H, Celli J, van Reeuwijk J, Rinne T, Glaudemans B, van Beusekom E, Rieu P, Newbury-Ecob RA, Chiang C, Brunner HG (2005) MYCN haploinsufficiency is associated with reduced brain size and intestinal atresias in Feingold syndrome. Nat Genet 37:465–467CrossRef

Charron J, Malynn BA, Fisher P, Stewart V, Jeannotte L, Goff SP, Robertson EJ, Alt FW (1992) Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene. Genes Dev 6:2248–2257CrossRef

Sawai S, Shimono A, Hanaoka K, Kondoh H (1991) Embryonic lethality resulting from disruption of both N-myc alleles in mouse zygotes. New Biol 3:861–869PubMed

Stanton BR, Perkins AS, Tessarollo L, Sassoon DA, Parada LF (1992) Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop. Genes Dev 6:2235–2247CrossRef

Knoepfler PS, Cheng PF, Eisenman RN (2002) N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev 16:699–712CrossRef

Celli J, van Bokhoven H, Brunner HG (2003) Feingold syndrome: clinical review and genetic mapping. Am J Hum Genet 122:294–300CrossRef

Frydman M, Katz M, Cabot SG, Soen G, Kauschansky A, Sirota L (1997) MODED: microcephaly-oculo-digito-esophageal-duodenal syndrome. Am J Med Genet 71:251–257CrossRef

Piersall LD, Dowton SB, McAlister WH, Waggoner DJ (2000) Vertebral anomalies in a new family with ODED syndrome. Clin Genet 57:444–448CrossRef

10.

Büttiker V, Wojtulewicz J, Wilson M (2000) Imperforate anus in Feingold syndrome. Am J Med Genet 92:166–169CrossRef

Title: End-stage renal failure, reflux nephropathy and Feingold’s syndrome
Authors: Mona Aslam
Hans van Bokhoven
Christopher Mark Taylor
Publication date: 01-01-2008
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 1/2008
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-007-0602-3

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Springer Medicine

End-stage renal failure, reflux nephropathy and Feingold’s syndrome

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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