Skip to main content
Top
Published in: European Archives of Paediatric Dentistry 3/2014

01-06-2014 | Original Scientific Article

Enamel defects on the maxillary premolars in patients with cleft lip and/or palate: a retrospective case-control study

Authors: S. Carpentier, E. Ghijselings, J. Schoenaers, C. Carels, A. Verdonck

Published in: European Archives of Paediatric Dentistry | Issue 3/2014

Login to get access

Abstract

Aim

The purpose of this study was to investigate the presence of developmental defects of enamel on maxillary premolars in patients with cleft lip and/or palate. In addition, the relationship with the surgical technique of soft palate closure was studied. Such a relationship could be suspected since formation of enamel occurs around the same time period as soft palate closure.

Materials and methods

The study consisted of three groups. Patients from the first group (n = 123) were recruited from the Cleft Lip and Palate Team of the University Hospitals Leuven (CLPT-UHL). The second group (n = 81) consisted of patients consulting the Cleft Lip and Palate Team of the Radboud University Medical Centre Nijmegen (CLPT-UMCN). Healthy non-cleft lip and/or palate patients (n = 100) recruited from a private orthodontic practice were enrolled in group 3. All maxillary premolars were examined.

Results

Out of the total sample, 43 patients showed developmental defects on one or more premolars. All defects occurred in patients of group 1 who received surgical closure by the CLPT-UHL. None of the patients from group 2 and 3 showed defects.

Conclusions

It can be suggested that the surgical technique, used by the CLPT-UHL for soft palate closure, causes these defects. It is postulated that the technique used by the CLPT-UHL leads to interference with the blood supply of the developing premolar at a critical stage of tooth enamel development. More research is needed to confirm these findings.
Literature
go back to reference Akcam MO, Evirgen S, Uslu O, Memikoglu UT. Dental anomalies in individuals with cleft lip and/or palate. Eur J Orthod. 2010;32:207–13.PubMedCrossRef Akcam MO, Evirgen S, Uslu O, Memikoglu UT. Dental anomalies in individuals with cleft lip and/or palate. Eur J Orthod. 2010;32:207–13.PubMedCrossRef
go back to reference Al Jamal GA, Hazza’a A, Rawashdeh MA. Prevalence of dental anomalies in a population of cleft lip and palate patients. Cleft Palate Craniofac J. 2010;47:413–20.PubMedCrossRef Al Jamal GA, Hazza’a A, Rawashdeh MA. Prevalence of dental anomalies in a population of cleft lip and palate patients. Cleft Palate Craniofac J. 2010;47:413–20.PubMedCrossRef
go back to reference Camporesi M, Baccetti T, Marinelli A, Defraia E, Franchi L. Maxillary dental anomalies in children with cleft lip and palate: a controlled study. Int J Paediatr Dent. 2010;20:442–50.PubMedCrossRef Camporesi M, Baccetti T, Marinelli A, Defraia E, Franchi L. Maxillary dental anomalies in children with cleft lip and palate: a controlled study. Int J Paediatr Dent. 2010;20:442–50.PubMedCrossRef
go back to reference Commission on Oral Health, Research and Epidemiology. An epidemiological index of developmental defects of dental enamal (DDE Index). Int Dent J. 1982;32:159–67. Commission on Oral Health, Research and Epidemiology. An epidemiological index of developmental defects of dental enamal (DDE Index). Int Dent J. 1982;32:159–67.
go back to reference Derijcke A, Eerens A, Carels C. The incidence of oral clefts: a review. Br J Oral Maxillofac Surg. 1996;34:488–94.PubMedCrossRef Derijcke A, Eerens A, Carels C. The incidence of oral clefts: a review. Br J Oral Maxillofac Surg. 1996;34:488–94.PubMedCrossRef
go back to reference Eerens K, Vlietinck R, Heidbuchel K, et al. Hypodontia and tooth formation in groups of children with cleft, siblings without cleft, and nonrelated controls. Cleft Palate Craniofac J. 2001;38:374–8.PubMedCrossRef Eerens K, Vlietinck R, Heidbuchel K, et al. Hypodontia and tooth formation in groups of children with cleft, siblings without cleft, and nonrelated controls. Cleft Palate Craniofac J. 2001;38:374–8.PubMedCrossRef
go back to reference Galante JM, Costa B, de Carvalho Carrara CF, Gomide MR. Prevalence of enamel hypoplasia in deciduous canines of patients with complete cleft lip and palate. Cleft Palate Craniofac J. 2005;42:675–8.PubMedCrossRef Galante JM, Costa B, de Carvalho Carrara CF, Gomide MR. Prevalence of enamel hypoplasia in deciduous canines of patients with complete cleft lip and palate. Cleft Palate Craniofac J. 2005;42:675–8.PubMedCrossRef
go back to reference Garn SM, Lewis AB, Vicinus JH. Third molar polymorphism and its significance to dental genetics. J Dent Res. 1963;42:1344–63.PubMedCrossRef Garn SM, Lewis AB, Vicinus JH. Third molar polymorphism and its significance to dental genetics. J Dent Res. 1963;42:1344–63.PubMedCrossRef
go back to reference Gomes AC, Neves LT, Gomide MR. Enamel defects in maxillary central incisors of infants with unilateral cleft lip. Cleft Palate Craniofac J. 2009;46:420–4.PubMedCrossRef Gomes AC, Neves LT, Gomide MR. Enamel defects in maxillary central incisors of infants with unilateral cleft lip. Cleft Palate Craniofac J. 2009;46:420–4.PubMedCrossRef
go back to reference Kotsomitis N, Dunne MP, Freer TJ. A genetic aetiology for some common dental anomalies: a pilot twin study. Aust Orthod J. 1996;14:172–8.PubMed Kotsomitis N, Dunne MP, Freer TJ. A genetic aetiology for some common dental anomalies: a pilot twin study. Aust Orthod J. 1996;14:172–8.PubMed
go back to reference Lekkas C, Latief BS, Ter Rahe SPN, Kuijpers-Jagtman AM. The adult unoperated cleft patient: absence of maxillary teeth outside the cleft area. Cleft Palate Craniofac J. 2000;37:17–20.PubMedCrossRef Lekkas C, Latief BS, Ter Rahe SPN, Kuijpers-Jagtman AM. The adult unoperated cleft patient: absence of maxillary teeth outside the cleft area. Cleft Palate Craniofac J. 2000;37:17–20.PubMedCrossRef
go back to reference Leow AM, Lo LJ. Palatoplasty: evolution and controversies. Chang Gung Med J. 2008;31:335–45.PubMed Leow AM, Lo LJ. Palatoplasty: evolution and controversies. Chang Gung Med J. 2008;31:335–45.PubMed
go back to reference Lucas VS, Gupta R, Ololade O, Gelbier M, Roberts GJ. Dental health indices and caries associated microflora in children with unilateral cleft lip and palate. Cleft Palate Craniofac J. 2000;37:447–52.PubMedCrossRef Lucas VS, Gupta R, Ololade O, Gelbier M, Roberts GJ. Dental health indices and caries associated microflora in children with unilateral cleft lip and palate. Cleft Palate Craniofac J. 2000;37:447–52.PubMedCrossRef
go back to reference Mangold E, Ludwig KU, Nöthen MM. Breakthroughs in the genetics of orofacial clefting. Trends Mol Med. 2011;17:725–33.PubMedCrossRef Mangold E, Ludwig KU, Nöthen MM. Breakthroughs in the genetics of orofacial clefting. Trends Mol Med. 2011;17:725–33.PubMedCrossRef
go back to reference Needleman HL, Leviton A, Allred E. Macroscopic enamel defects of primary anterior teeth-types, prevalence, and distribution. Pediatr Dent. 1991;13:208–16.PubMed Needleman HL, Leviton A, Allred E. Macroscopic enamel defects of primary anterior teeth-types, prevalence, and distribution. Pediatr Dent. 1991;13:208–16.PubMed
go back to reference Ranta R. A review of tooth formation in children with cleft lip/palate. Am J Orthod Dentofac Orthop. 1986;90:11–8.CrossRef Ranta R. A review of tooth formation in children with cleft lip/palate. Am J Orthod Dentofac Orthop. 1986;90:11–8.CrossRef
go back to reference Ribeiro LL, DasNeves LT, Costa B, Gomide MR. Dental anomalies of the permanent lateral incisors and prevalence of hypodontia outside the cleft area in complete unilateral cleft lip and palate. Cleft Palate Craniofac J. 2003;40:172–5.CrossRef Ribeiro LL, DasNeves LT, Costa B, Gomide MR. Dental anomalies of the permanent lateral incisors and prevalence of hypodontia outside the cleft area in complete unilateral cleft lip and palate. Cleft Palate Craniofac J. 2003;40:172–5.CrossRef
go back to reference Ruiz LA, Maya RR, D’Alpino PH, Atta MT, Svizero NR. Prevalence of enamel defects in permanent teeth of patients with complete cleft lip and palate. Cleft Palate Craniofac J. 2012; Epub ahead of print. Ruiz LA, Maya RR, D’Alpino PH, Atta MT, Svizero NR. Prevalence of enamel defects in permanent teeth of patients with complete cleft lip and palate. Cleft Palate Craniofac J. 2012; Epub ahead of print.
go back to reference Slayton RL, Warren JJ, Kannellis MJ, Levy SM, Islam M. Prevalence of enamel hypoplasia and isolated opacities in the primary dentition. Pediatr Dent. 2001;23:32–6.PubMed Slayton RL, Warren JJ, Kannellis MJ, Levy SM, Islam M. Prevalence of enamel hypoplasia and isolated opacities in the primary dentition. Pediatr Dent. 2001;23:32–6.PubMed
go back to reference Sofaer JA. Human tooth-size asymmetry in cleft lip with of without cleft palate. Arch Oral Biol. 1979;24:141–6.PubMedCrossRef Sofaer JA. Human tooth-size asymmetry in cleft lip with of without cleft palate. Arch Oral Biol. 1979;24:141–6.PubMedCrossRef
go back to reference ten Cate AR. Oral Histology: development, structure and function. In: ten Cate AR, editor. Amelogenesis. Rio de Janeiro: Guanabara Koogan; 2001. p. 186–204. ten Cate AR. Oral Histology: development, structure and function. In: ten Cate AR, editor. Amelogenesis. Rio de Janeiro: Guanabara Koogan; 2001. p. 186–204.
go back to reference Van der Poorten V, Ostyn F, Van Kerckhoven W, et al. The Leuven staged supraperiosteal retropositioning repair: long-term velopharyngeal function in non-syndromic cleft palate. B-ENT. 2006;2:35–43. Van der Poorten V, Ostyn F, Van Kerckhoven W, et al. The Leuven staged supraperiosteal retropositioning repair: long-term velopharyngeal function in non-syndromic cleft palate. B-ENT. 2006;2:35–43.
go back to reference Via WF Jr, Churchill JA. Relationship of enamel hypoplasia to abnormal events of gestation and birth. J Am Dent Assoc. 1959;59:702–7.PubMed Via WF Jr, Churchill JA. Relationship of enamel hypoplasia to abnormal events of gestation and birth. J Am Dent Assoc. 1959;59:702–7.PubMed
Metadata
Title
Enamel defects on the maxillary premolars in patients with cleft lip and/or palate: a retrospective case-control study
Authors
S. Carpentier
E. Ghijselings
J. Schoenaers
C. Carels
A. Verdonck
Publication date
01-06-2014
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Paediatric Dentistry / Issue 3/2014
Print ISSN: 1818-6300
Electronic ISSN: 1996-9805
DOI
https://doi.org/10.1007/s40368-013-0078-8

Other articles of this Issue 3/2014

European Archives of Paediatric Dentistry 3/2014 Go to the issue