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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-11-2008 | Case Report

Emulsification and inverted hypopyon formation of oxane HD in the anterior chamber

Authors: Wico W. Lai, David Wong, Kenneth K. Li, Po-lin Leow

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 11/2008

Abstract

Background

Oxane HD® is a “heavier-than-water” silicone oil which has a specific gravity of 1.02 g/cm³. When dispersed into droplets, one expects them to sink. We report a case of emulsification of Oxane HD in an eye that unexpectedly manifested as an “inverted hypopyon”.

Methods

The clinical findings of a 45-year-old man who underwent pars plana vitrectomy and Oxane HD endotamponade for a phakic inferior rhegmatogenous retinal detachment are described.

Results

A large silicone oil globule was noted to be floating in the anterior chamber on postoperative day 1. Emulsification of the globule and inverted hypopyon formation were subsequently observed at 2 months postoperatively.

Conclusions

Emulsification and inverted hypopyon formation in the anterior chamber may occur with Oxane HD. One explanation might be that the Oxane HD has separated out into its constituent components of silicone and RMN3, which raises questions as to the basis for its claim to be a heavier-than-water tamponade.

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Rizzo S, Genovesi-Ebert F, Belting C, Vento A, Cresti F (2005) A pilot study on the use of silicone oil-RMN3 as heavier-than-water endotamponade agent. Graefes Arch Clin Exp Ophthalmol 243:1153–1157PubMedCrossRef

Jackson TL, Thiagarajan M, Murthy R, Snead MP, Wong D, Williamson TH (2001) Pupillary block glaucoma in phakic and pseudophakic patients after vitrectomy with silicone oil injection. Am J Ophthalmol. 132(3):414–416PubMedCrossRef

Tomlins PJ, Woodcock MGL, Spencer N, Kirkby GR (2007) Nuclear magnetic resonance analysis of emulsified silicone oil RMN03 (Oxane HD). Br J Ophthalmol 91:1379–1381PubMedCrossRef

Oxane HD (2003) Exclusive heavier than water, long-term endotamponade (package insert). Bausch & Lomb Toulouse, France

Wetterqvist C, Wong D, Williams R, Stappler T, Herbert E, Freeburn S (2004) Br J Ophthalmol 88:692–696PubMedCrossRef

Wong D, Van Meurs JC, Stappler T, Groenewald C, Pearce OA, McGalliard JN, Manousakis E, Herbert EN (2005) A pilot study on the use of a perfluorohexyloctance/silicone oil solution as a heavier than water internal tamponade agent. Br J Ophthalmol 89:662–665PubMedCrossRef

Stappler T, Heimann H, Wong D et al (2008) Heavy tamponade 2: Densiron 68(R) in routine clinical practice: anatomical and functional outcomes of a consecutive case series. Eye Feb 29 [Epub ahead of print]

Petersen J (1987) The physical and surgical aspects of silicone oil in the vitreous cavity. Graefes Arch Clin Exp Ophthalmol 225:452–456PubMedCrossRef

Title: Emulsification and inverted hypopyon formation of oxane HD in the anterior chamber
Authors: Wico W. Lai
David Wong
Kenneth K. Li
Po-lin Leow
Publication date: 01-11-2008
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 11/2008
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-008-0851-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Emulsification and inverted hypopyon formation of oxane HD in the anterior chamber

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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