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Published in: Drugs 7/2009

01-05-2009 | Adis Drug Profile

Emtricitabine/Tenofovir Disoproxil Fumarate

In Combination with a Protease Inhibitor in HIV-1 Infection

Author: Caroline M. Perry

Published in: Drugs | Issue 7/2009

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Abstract

  • ▲ Emtricitabine, a nucleoside reverse transcriptase inhibitor (RTI), and tenofovir disoproxil fumarate (tenofovir DF), a nucleotide RTI, as a fixed-dose combination tablet (emtricitabine/tenofovir DF) for once-daily oral administration, are used as the nucleoside/nucleotide RTI backbone in combination with other antiretroviral agents, including ritonavir-boosted protease inhibitors (PIs), in the treatment of adults with HIV-1 infection.
  • ▲ Emtricitabine and tenofovir DF show good activity against laboratory strains and clinical isolates of HIV-1 in vitro, although strains with resistance to emtricitabine or tenofovir have also been reported.
  • ▲ Regimens consisting of once-daily emtricitabine/tenofovir DF 200 mg/300 mg plus lopinavir/ritonavir (in the randomized, double-blind, placebo-matched, multicentre HEAT study) or boosted atazanavir or efavirenz (in the randomized, partially-blind, multicentre ACTG 5202 trial) were effective in the initial treatment of patients with HIV-1 infection (with screening plasma HIV-1 RNA levels of ≥100 000 copies/mL in ACTG 5202).
  • ▲ In other randomized studies, emtricitabine/tenofovir DF 200 mg/300 mg once daily was an effective backbone for boosted PI-based regimens in the initial treatment of HIV-1 infection. Treatment-experienced patients with HIV-1 infection also experienced beneficial virological effects when treated with similar regimens.
  • ▲ Emtricitabine/tenofovir DF in combination with various boosted PIs was generally well tolerated by adults with HIV-1 infection.
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Metadata
Title
Emtricitabine/Tenofovir Disoproxil Fumarate
In Combination with a Protease Inhibitor in HIV-1 Infection
Author
Caroline M. Perry
Publication date
01-05-2009
Publisher
Springer International Publishing
Published in
Drugs / Issue 7/2009
Print ISSN: 0012-6667
Electronic ISSN: 1179-1950
DOI
https://doi.org/10.2165/00003495-200969070-00005

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