Published in:
Open Access
01-12-2011 | Poster presentation
Emperipolesis and cell death in NOD2-related Blau Syndrome and Crohn’s disease
Authors:
Carl EI Janssen, Carlos D Rose, Antonio Naranjo, Brigitte Bader-Meunier, Rolando Cimaz, Miroslav Harjacek, Pierre Quartier, Rebecca TenCate, Caroline Thomee, Isabelle Cleynen, Tammy M Martin, Gert De Hertogh, Tania Roskams, Valeer J Desmet, Carine H Wouters
Published in:
Pediatric Rheumatology
|
Special Issue 1/2011
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Excerpt
Blau Syndrome (BS), a rare autoinflammatory disease characterized by non-caseating granulomas, is caused by gain-of-function mutations in NOD2. Crohn’s disease (CD) is associated with intestinal granulomas, and SNPs in NOD2. Emperipolesis, the ‘inside round about wandering’ of lymphocytes within other cells is a typical feature of Rosai-Dorfman disease, and seen occasionally in malignancies. Cell survival and cell death are possible outcomes for both the engulfed and engulfing cells. …
