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Cancer Cell International
Published in: Cancer Cell International 1/2020

Open Access 01-12-2020 | Review

Emerging role of long noncoding RNA-encoded micropeptides in cancer

Authors: Mujie Ye, Jingjing Zhang, Meng Wei, Baihui Liu, Kuiran Dong

Published in: Cancer Cell International | Issue 1/2020

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Abstract

Increasing evidence has indicated that long noncoding RNAs (lncRNAs) play various important roles in the development of cancers. The widespread applications of ribosome profiling and ribosome nascent chain complex sequencing revealed that some short open reading frames of lncRNAs have micropeptide-coding potential. The resulting micropeptides have been shown to participate in N6-methyladenosine modification, tumor angiogenesis, cancer metabolism, and signal transduction. This review summarizes current information regarding the reported roles of lncRNA-encoded micropeptides in cancer, and explores the potential clinical value of these micropeptides in the development of anti-cancer drugs and prognostic tumor biomarkers.
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Metadata
Title
Emerging role of long noncoding RNA-encoded micropeptides in cancer
Authors
Mujie Ye
Jingjing Zhang
Meng Wei
Baihui Liu
Kuiran Dong
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2020
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-020-01589-x

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