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Molecular Cancer
Published in: Molecular Cancer 1/2018

Open Access 01-12-2018 | Review

Emerging function and potential diagnostic value of circular RNAs in cancer

Authors: Xianglun Cui, Jianxun Wang, Zongjun Guo, Mengyang Li, Mingyu Li, Si Liu, Haoran Liu, Wenjing Li, Xunhua Yin, Jiaping Tao, Wenhua Xu

Published in: Molecular Cancer | Issue 1/2018

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Abstract

As a novel class of endogenous RNAs, circRNAs, have a covalently closed continuous loop, with neither a 5’to 3’polarity, nor a polyadenylated tail. Numerous circRNAs have been characterized by abundance, stabilization, conservation, and exhibit tissue/developmental stage-specific expression. Furthermore, circRNAs play vital roles in tumorigenesis and metastasis, such as functioning as a ceRNA or miRNA sponge, interacting with protein and encoding protein. Increasing evidence has revealed that it potentially serves as a required novel biomarker for cancer diagnosis. This review summarized the latest research on circRNAs, including its classification and biogenesis, mechanism and functions, as well as circRNAs in different cancers, as a potential biomarker.
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Metadata
Title
Emerging function and potential diagnostic value of circular RNAs in cancer
Authors
Xianglun Cui
Jianxun Wang
Zongjun Guo
Mengyang Li
Mingyu Li
Si Liu
Haoran Liu
Wenjing Li
Xunhua Yin
Jiaping Tao
Wenhua Xu
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2018
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/s12943-018-0877-y

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