Published in:
01-02-2010 | DeMeester Feschrift
Emerging Concepts of Bile Reflux in the Constellation of Gastroesophageal Reflux Disease
Authors:
Werner K. H. Kauer, Hubert J. Stein
Published in:
Journal of Gastrointestinal Surgery
|
Special Issue 1/2010
Login to get access
Abstract
Rationale
Reflux of gastric and duodenal contents in patients with gastroesophageal reflux disease (GERD) has been postulated as a major cause of complications, such as Barrett’s esophagus or malignant degeneration.
Findings
We present a summary of experimental, clinical, and immunohistochemical studies that show that acid and bile reflux are increased in patients who suffer from GERD, are the key factor in the pathogenesis of Barrett’s esophagus, and are possibly related to the development of esophageal adenocarcinoma.