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Published in: Cancer Cell International 1/2021

Open Access 01-12-2021 | Review

Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin

Authors: Marjan Talebi, Mohsen Talebi, Tahereh Farkhondeh, Jesus Simal-Gandara, Dalia M. Kopustinskiene, Jurga Bernatoniene, Saeed Samarghandian

Published in: Cancer Cell International | Issue 1/2021

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Abstract

Chrysin has been shown to exert several beneficial pharmacological activities. Chrysin has anti-cancer, anti-viral, anti-diabetic, neuroprotective, cardioprotective, hepatoprotective, and renoprotective as well as gastrointestinal, respiratory, reproductive, ocular, and skin protective effects through modulating signaling pathway involved in apoptosis, oxidative stress, and inflammation. In the current review, we discussed the emerging cellular and molecular mechanisms underlying therapeutic indications of chrysin in various cancers. Online databases comprising Scopus, PubMed, Embase, ProQuest, Science Direct, Web of Science, and the search engine Google Scholar were searched for available and eligible research articles. The search was conducted by using MeSH terms and keywords in title, abstract, and keywords. In conclusion, experimental studies indicated that chrysin could ameliorate cancers of the breast, gastrointestinal tract, liver and hepatocytes, bladder, male and female reproductive systems, choroid, respiratory tract, thyroid, skin, eye, brain, blood cells, leukemia, osteoblast, and lymph. However, more studies are needed to enhance the bioavailability of chrysin and evaluate this agent in clinical trial studies.

Graphic abstract

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Metadata
Title
Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
Authors
Marjan Talebi
Mohsen Talebi
Tahereh Farkhondeh
Jesus Simal-Gandara
Dalia M. Kopustinskiene
Jurga Bernatoniene
Saeed Samarghandian
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2021
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-021-01906-y

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