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International Orthopaedics
Published in: International Orthopaedics 8/2010

Open Access 01-12-2010 | Original Paper

Elevated levels of numerous cytokines in drainage fluid after primary total hip arthroplasty

Authors: Huub J. L. van der Heide, Peter M. van der Kraan, Willard J. Rijnberg, Pieter Buma, B. Willem Schreurs

Published in: International Orthopaedics | Issue 8/2010

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Abstract

As cytokines are involved in wound healing and other inflammatory processes, it could be valuable to measure their levels at the operative site. This study was conducted to investigate whether different cytokines are measurable in drainage fluid and, when measurable, whether we can find a difference in cytokine levels between one and six hours postoperatively. Samples from the drainage system in 30 consecutive patients undergoing primary total hip replacement were collected at one and six hours after closure of the wound. Levels of several cytokines were measured in the drainage fluids. A significant elevation of almost all cytokines was observed between the sample after one hour and six hours postoperatively. We found a strong correlation between the different pro-inflammatory cytokines. The IL-6 to IL-10 ratio were also raised, showing a pro-inflammatory predominance. Levels were much higher than those previously shown in serum.
Literature
1.
Andersson I, Tylman M, Bengtson JP et al (2001) Complement split products and pro-inflammatory cytokines in salvaged blood after hip and knee arthroplasty. Can J Anaesth 48:251–255CrossRefPubMed
2.
Andres BM, Taub DD, Gurkan I et al (2003) Postoperative fever after total knee arthroplasty: the role of cytokines. Clin Orthop 415:221–231CrossRefPubMed
3.
Baker EA, El Gaddal S, Williams L et al (2006) Profiles of inflammatory cytokines following colorectal surgery: relationship with wound healing and outcome. Wound Repair Regen 14:566–572CrossRefPubMed
4.
Chalmers J, Gray DH, Rush J (1975) Observations on the induction of bone in soft tissues. J Bone Joint Surg Br 57:36–45PubMed
5.
Damas P, Ledoux D, Nys M et al (1992) Cytokine serum level during severe sepsis in human IL-6 as a marker of severity. Ann Surg 215:356–362CrossRefPubMed
6.
de Jager W, te Veldhuis H, Prakken BJ et al (2003) Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells. Clin Diagn Lab Immunol 10:133–139PubMed
7.
Di Vita G, Patti R, D'Agostino P et al (2006) Modifications in the production of cytokines and growth factors in drainage fluids following mesh implantation after incisional hernia repair. Am J Surg 191:785–790CrossRefPubMed
8.
Drenth JP, Van Uum SH, van Deuren M et al (1995) Endurance run increases circulating IL-6 and IL-1ra but down regulates ex vivo TNF-alpha and IL-1 beta production. J Appl Physiol 79:1497–1503PubMed
9.
Frank SM, Kluger MJ, Kunkel SL (2000) Elevated thermostatic setpoint in postoperative patients. Anesthesiology 93:1426–1431CrossRefPubMed
10.
Frieling JT, van Deuren M, Wijdenes J et al (1995) Circulating interleukin-6 receptor in patients with sepsis syndrome. J Infect Dis 171:469–472PubMed
11.
Giannoudis PV (2003) Current concepts of the inflammatory response after major trauma: an update. Injury 34:397–404PubMed
12.
Giannoudis PV, Smith RM, Perry SL et al (2000) Immediate IL-10 expression following major orthopaedic trauma: relationship to anti-inflammatory response and subsequent development of sepsis. Intensive Care Med 26:1076–1081CrossRefPubMed
13.
Hernigou P, Intrator L, Bahrami T et al (1999) Interleukin-6 in the blood of patients with total hip arthroplasty without loosening. Clin Orthop Relat Res 366:147–154CrossRefPubMed
14.
Hundric-Haspl Z, Pecina M, Haspl M et al (2006) Plasma cytokines as markers of aseptic prosthesis loosening. Clin Orthop Relat Res 453:299–304CrossRefPubMed
15.
Kose KC, Cebesoy O, Altinel L (2007) HO prevention and the combined therapeutic protocol-do we really need it? Int Orthop 31:133–134CrossRefPubMed
16.
Kristiansson M, Soop M, Sundqvist KG et al (1998) Local vs. systemic immune and haemostatic response to hip arthroplasty. Eur J Anaesthesiol 15:260–270PubMed
17.
Lahat N, Zlotnick AY, Shtiller R et al (1992) Serum levels of IL-1, IL-6 and tumour necrosis factors in patients undergoing coronary artery bypass grafts or cholecystectomy. Clin Exp Immunol 89:255–260CrossRefPubMed
18.
Lind M, Deleuran B, Yssel H et al (1995) IL-4 and IL-13, but not IL-10, are chemotactic factors for human osteoblasts. Cytokine 7:78–82
19.
Mahy PR, Urist MR (1988) Experimental heterotopic bone formation induced by bone morphogenetic protein and recombinant human interleukin-1B. Clin Orthop 237:236–244PubMed
20.
Menger MD, Vollmar B (2004) Surgical trauma: hyperinflammation versus immunosuppression? Langenbecks Arch Surg 389:475–484CrossRefPubMed
21.
Miyawaki T, Maeda S, Koyama Y et al (1998) Elevation of plasma interleukin-6 level is involved in postoperative fever following major oral and maxillofacial surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 85:146–152CrossRefPubMed
22.
Neal BC, Rodgers A, Clark T et al (2000) A systematic survey of 13 randomized trials of non-steroidal anti-inflammatory drugs for the prevention of heterotopic bone formation after major hip surgery. Acta Orthop Scand 71:122–128CrossRefPubMed
23.
Pakos EE, Pitouli EJ, Tsekeris PG et al (2006) Prevention of heterotopic ossification in high-risk patients with total hip arthroplasty: the experience of a combined therapeutic protocol. Int Orthop 30:79–83CrossRefPubMed
24.
Porter JM (1999) Cytokines and pleural drainage fluid: do local levels make a difference? Chest 115:1489–1490CrossRefPubMed
25.
Pullicino EA, Carli F, Poole S et al (1990) The relationship between the circulating concentrations of interleukin 6 (IL-6), tumor necrosis factor (TNF) and the acute phase response to elective surgery and accidental injury. Lymphokine Res 9:231–238PubMed
26.
Southern EP, Huo MH, Mehta JR et al (1995) Unwashed wound drainage blood. What are we giving our patients? Clin Orthop 320:235–246PubMed
27.
Taniguchi T, Koido Y, Aiboshi J et al (1999) The ratio of interleukin-6 to interleukin-10 correlates with severity in patients with chest and abdominal trauma. Am J Emerg Med 17:548–551CrossRefPubMed
28.
van Deuren M, Twickler TB, Waal Malefyt MC et al (1998) Elective orthopedic surgery, a model for the study of cytokine activation and regulation. Cytokine 10:897–903CrossRefPubMed
29.
Weissflog D, Kroegel C, Luttmann W et al (1999) Leukocyte infiltration and secretion of cytokines in pleural drainage fluid after thoracic surgery: impaired cytokine response in malignancy and postoperative complications. Chest 115:1604–1610CrossRefPubMed
30.
Yamauchi H, Kobayashi E, Yoshida T et al (1998) Changes in immune-endocrine response after surgery. Cytokine 10:549–554CrossRefPubMed
Metadata
Title
Elevated levels of numerous cytokines in drainage fluid after primary total hip arthroplasty
Authors
Huub J. L. van der Heide
Peter M. van der Kraan
Willard J. Rijnberg
Pieter Buma
B. Willem Schreurs
Publication date
01-12-2010
Publisher
Springer-Verlag
Published in
International Orthopaedics / Issue 8/2010
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-009-0852-8

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