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Clinical Research in Cardiology

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01-12-2010 | Original Paper

Elevated level of ADAMTS4 in plasma and peripheral monocytes from patients with acute coronary syndrome

Authors: Yanping Zha, Yong Chen, Fayun Xu, Jie Zhang, Tian Li, Chuanyan Zhao, Lianqun Cui

Published in: Clinical Research in Cardiology | Issue 12/2010

Abstract

Objectives

A recent study shows that ADAMTS4 is expressed in macrophage-rich areas of human atherosclerotic carotid plaques and coronary unstable plaques, suggesting a pathogenic role of ADAMTS4 in the development of acute coronary syndrome (ACS). We investigated (a) whether the expression level of ADAMTS4 in plasma and peripheral blood mononuclear cells was affected; and (b) whether there was a relationship with hs-CRP level and the stability of coronary atherosclerotic plaque in patients with ACS.

Methods

Our study included 30 normal controls and 120 patients including 40 with stable angina (SA), 50 with unstable angina (UA), and 30 with acute myocardial infarction (AMI). The expression of ADAMTS4 in monocytes was analyzed by RT-PCR and plasma ADAMTS4 level was determined by ELISA. All coronary stenosis with >30% diameter reduction was assessed by angiographic coronary stenosis morphology.

Results

Patients with ACS showed a significant increase of ADAMTS4 (2.7 ± 0.4) expression in monocytes compared with controls (1.1 ± 0.2) and the SA group (1.3 ± 0.2) (P < 0.001). Plasma ADAMTS4 also showed a higher level in ACS patients (100.2 ± 31.6 ng/ml) than in control (47.5 ± 9.0 ng/ml, P < 0.001) and the SA group (54.3 ± 13.2 ng/ml, P < 0.001). Moreover, we found a positive correlation between hs-CRP and ADAMTS4 expression in monocytes as well as in plasma. There was also a positive correlation of ADAMTS4 expression in monocytes and plasma with complex coronary stenosis (r ₁ = 0.61, r ₂ = 0.57, P < 0.001).

Conclusions

Patients with ACS showed increased ADAMTS4 expression, which may aggravate the development of atherosclerosis and instability of atherosclerotic plaques. Therefore, the ADAMTS4 expression may be a valuable marker for predicting the severity of ACS.

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Title: Elevated level of ADAMTS4 in plasma and peripheral monocytes from patients with acute coronary syndrome
Authors: Yanping Zha
Yong Chen
Fayun Xu
Jie Zhang
Tian Li
Chuanyan Zhao
Lianqun Cui
Publication date: 01-12-2010
Publisher: Springer-Verlag
Published in: Clinical Research in Cardiology / Issue 12/2010
Print ISSN: 1861-0684
Electronic ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-010-0183-1

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Springer Medicine

Elevated level of ADAMTS4 in plasma and peripheral monocytes from patients with acute coronary syndrome

Abstract

Objectives

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

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