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International Journal of Colorectal Disease
Published in: International Journal of Colorectal Disease 9/2010

01-09-2010 | Original Article

Electromechanical characteristics of the human colon in vitro: is there any difference between the right and left colon?

Authors: Eun Kyung Choe, Jung Sun Moon, Suk Bae Moon, In-Suk So, Kyu Joo Park

Published in: International Journal of Colorectal Disease | Issue 9/2010

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Abstract

Purpose

We examined the electrical and mechanical characteristics of the smooth muscles in the human colon at the muscle cell, the muscle strip, and at the whole tissue levels

Methods

Conventional microelectrode recordings and tension recordings were performed.

Results

There was no difference in resting membrane potential, frequency, and amplitude of slow waves between the right and left colon; but there were significant differences in frequency and amplitude of the slow waves between inner circular muscle (CM) and longitudinal muscle (LM), and between inner CM and outer CM, but not between outer CM and LM. On tension recording of CM and LM strip and colonic segment, amplitude, frequency, and area under the curve showed no difference between the right and left colon. In whole colonic segment, high amplitude dominant waves (DW) were found both in CM and LM. Low amplitude non-DWs were detected only in CM, more commonly in right colon and propagated aborally. DWs in the CM were associated with DWs in the LM. In the CM of the left colon, all DWs in the CM propagetd aborally ending-up with DW in the LM layer. However, in the right colon, mixed pattern of propagation was detected in adjacent recording sites in 60% of tissues examined.

Conclusion

Electrophysiologic and mechanical characteristics were similar between the right and left human colon. However, the retrograde propagation of both DWs and non-DWs in the CM was more frequent in the right colon, accounting for mixing function in this region of the human colon.
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Metadata
Title
Electromechanical characteristics of the human colon in vitro: is there any difference between the right and left colon?
Authors
Eun Kyung Choe
Jung Sun Moon
Suk Bae Moon
In-Suk So
Kyu Joo Park
Publication date
01-09-2010
Publisher
Springer-Verlag
Published in
International Journal of Colorectal Disease / Issue 9/2010
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-010-0966-x

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