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01-09-2019 | Electroencephalography | Original Paper

Cross-Species Investigation on Resting State Electroencephalogram

Authors: Fengrui Zhang, Feixue Wang, Lupeng Yue, Huijuan Zhang, Weiwei Peng, Li Hu

Published in: Brain Topography | Issue 5/2019

Abstract

Resting state electroencephalography (EEG) during eyes-closed and eyes-open conditions is widely used to evaluate brain states of healthy populations and brain dysfunctions in clinical conditions. Although several results have been obtained by measuring these brain activities in humans, it remains unclear whether the same results can be replicated in animals, i.e., whether the physiological properties revealed by these findings are phylogenetically conserved across species. In the present study, we describe a paradigm for recording resting state EEG activities during eyes-closed and eyes-open conditions from rats, and investigated the differences between eyes-closed and eyes-open conditions for humans and rats. We found that compared to the eyes-open condition, human EEG spectral amplitude in the eyes-closed condition was significantly higher at 8–12 Hz and 18–22 Hz in the occipital region, but significantly lower at 18–22 Hz and 30–100 Hz in the frontal region. In contrast, rat EEG spectral amplitude was significantly higher in the eyes-closed condition than in the eyes-open condition at 1–4 Hz, 8–12 Hz, and 13–17 Hz in the frontal-central region. In both species, the 1/f-like power spectrum scaling of resting state EEG activities was significantly higher in the eyes-closed condition than in the eyes-open condition at parietal-occipital and frontal regions. These results provided a neurophysiological basis for future translational studies from experimental animal findings to human psychophysiology, since the validity of such translation critically relies on a well-established experimental paradigm and a carefully-examined signal characteristic to bridge the gaps across different species.

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Title: Cross-Species Investigation on Resting State Electroencephalogram
Authors: Fengrui Zhang
Feixue Wang
Lupeng Yue
Huijuan Zhang
Weiwei Peng
Li Hu
Publication date: 01-09-2019
Publisher: Springer US
Keyword: Electroencephalography
Published in: Brain Topography / Issue 5/2019
Print ISSN: 0896-0267
Electronic ISSN: 1573-6792
DOI: https://doi.org/10.1007/s10548-019-00723-x

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Cross-Species Investigation on Resting State Electroencephalogram

Abstract

At a glance: The STEP trials

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Abstract

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