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European Journal of Medical Research

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Open Access 01-12-2014 | Research article

Elective orthopedic and cardiopulmonary bypass surgery causes a reduction in serum endostatin levels

Authors: Torbjörn Åkerfeldt, Lena Gunningberg, Christine Leo Swenne, Göran Ronquist, Anders Larsson

Published in: European Journal of Medical Research | Issue 1/2014

Abstract

Background

Endostatin is an endogenous inhibitor of angiogenesis that inhibits neovascularisation. The aim of the study was to evaluate the effect of elective surgery on endostatin levels.

Methods

Blood samples were collected prior to elective surgery and 4 and 30 days postoperatively in 2 patient groups: orthopedic surgery (n =27) and coronary bypass patients (n =21). Serum endostatin levels were measured by ELISA.

Results

Serum endostatin was significantly reduced 30 days after surgery in comparison with presurgical values in both the orthopedic (P =0.03) and cardiopulmonary surgery (P =0.04) group.

Conclusion

Serum endostatin is reduced 30 days after surgery. This reduction would favor angiogenesis and wound-healing.

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Muragaki Y, Abe N, Ninomiya Y, Olsen BR, Ooshima A: The human alpha 1(XV) collagen chain contains a large amino-terminal non-triple helical domain with a tandem repeat structure and homology to alpha 1(XVIII) collagen. J Biol Chem 1994, 269(6):4042–4046.PubMed

Rehn M, Pihlajaniemi T: Alpha 1(XVIII), a collagen chain with frequent interruptions in the collagenous sequence, a distinct tissue distribution, and homology with type XV collagen. Proc Natl Acad Sci U S A 1994, 91(10):4234–4238. 10.1073/pnas.91.10.4234PubMedPubMedCentralCrossRef

O'Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, Flynn E, Birkhead JR, Olsen BR, Folkman J: Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 1997, 88(2):277–285. 10.1016/S0092-8674(00)81848-6PubMedCrossRef

Sasaki T, Fukai N, Mann K, Gohring W, Olsen BR, Timpl R: Structure, function and tissue forms of the C-terminal globular domain of collagen XVIII containing the angiogenesis inhibitor endostatin. EMBO J 1998, 17(15):4249–4256. 10.1093/emboj/17.15.4249PubMedPubMedCentralCrossRef

Muntner P, He J, Hamm L, Loria C, Whelton PK: Renal insufficiency and subsequent death resulting from cardiovascular disease in the United States. J Am Soc Nephrol 2002, 13(3):745–753.PubMed

Felbor U, Dreier L, Bryant RA, Ploegh HL, Olsen BR, Mothes W: Secreted cathepsin L generates endostatin from collagen XVIII. EMBO J 2000, 19(6):1187–1194. 10.1093/emboj/19.6.1187PubMedPubMedCentralCrossRef

Ferreras M, Felbor U, Lenhard T, Olsen BR, Delaisse J: Generation and degradation of human endostatin proteins by various proteinases. FEBS Lett 2000, 486(3):247–251. 10.1016/S0014-5793(00)02249-3PubMedCrossRef

Wen W, Moses MA, Wiederschain D, Arbiser JL, Folkman J: The generation of endostatin is mediated by elastase. Cancer Res 1999, 59(24):6052–6056.PubMed

Liu Z, Li Y, Zhao W, Ma Y, Yang X: Demonstration of vasculogenic mimicry in astrocytomas and effects of Endostar on U251 cells. Pathol Res Pract 2011, 207(10):645–651. 10.1016/j.prp.2011.07.012PubMedCrossRef

10.

Folkman J: Antiangiogenesis in cancer therapy - endostatin and its mechanisms of action. Exp Cell Res 2006, 312(5):594–607. 10.1016/j.yexcr.2005.11.015PubMedCrossRef

11.

Abdollahi A, Hahnfeldt P, Maercker C, Grone HJ, Debus J, Ansorge W, Folkman J, Hlatky L, Huber PE: Endostatin's antiangiogenic signaling network. Mol Cell 2004, 13(5):649–663. 10.1016/S1097-2765(04)00102-9PubMedCrossRef

12.

Chen W, Fu J, Liu Q, Ruan C, Xiao S: Retroviral endostatin gene transfer inhibits human colon cancer cell growth in vivo . Chin Med J (Engl) 2003, 116(10):1582–1584.

13.

Li J, Dong X, Xu Z, Jiang X, Jiang H, Krissansen GW, Sun X: Endostatin gene therapy enhances the efficacy of paclitaxel to suppress breast cancers and metastases in mice. J Biomed Sci 2008, 15(1):99–109. 10.1007/s11373-007-9201-3PubMedCrossRef

14.

Michaels J, Dobryansky M, Galiano RD, Bhatt KA, Ashinoff R, Ceradini DJ, Gurtner GC: Topical vascular endothelial growth factor reverses delayed wound healing secondary to angiogenesis inhibitor administration. Wound Repair Regen 2005, 13(5):506–512. 10.1111/j.1067-1927.2005.00071.xPubMedCrossRef

15.

Seppinen L, Sormunen R, Soini Y, Elamaa H, Heljasvaara R, Pihlajaniemi T: Lack of collagen XVIII accelerates cutaneous wound healing, while overexpression of its endostatin domain leads to delayed healing. Matrix Biol 2008, 27(6):535–546. 10.1016/j.matbio.2008.03.003PubMedCrossRef

16.

Richter AG, McKeown S, Rathinam S, Harper L, Rajesh P, McAuley DF, Heljasvaara R, Thickett DR: Soluble endostatin is a novel inhibitor of epithelial repair in idiopathic pulmonary fibrosis. Thorax 2009, 64(2):156–161. 10.1136/thx.2008.102814PubMedCrossRef

17.

Ma L, Elliott SN, Cirino G, Buret A, Ignarro LJ, Wallace JL: Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release. Proc Natl Acad Sci U S A 2001, 98(11):6470–6475. 10.1073/pnas.111150798PubMedPubMedCentralCrossRef

18.

Stechmiller JK: Understanding the role of nutrition and wound healing. Nutr Clin Pract 2010, 25(1):61–68. 10.1177/0884533609358997PubMedCrossRef

19.

Mnif H, Koubaa M, Zrig M, Trabelsi R, Abid A: Elderly patient's mortality and morbidity following trochanteric fracture. A prospective study of 100 cases. Orthop Traumatol Surg Res 2009, 95(7):505–510. 10.1016/j.otsr.2009.08.001PubMedCrossRef

20.

Martin CT, Pugely AJ, Gao Y, Wolf BR: Risk factors for thirty-day morbidity and mortality following knee arthroscopy: a review of 12,271 patients from the national surgical quality improvement program database. J Bone Joint Surg Am 2013, 95(14):e981–10. 10.2106/JBJS.L.01440CrossRef

21.

Namba RS, Inacio MC, Paxton EW: Risk factors associated with deep surgical site infections after primary total knee arthroplasty: an analysis of 56,216 knees. J Bone Joint Surg Am 2013, 95(9):775–782. 10.2106/JBJS.L.00211PubMedCrossRef

22.

Akerfeldt T, Larsson A: Pentraxin 3 increase is much less pronounced than C-reactive protein increase after surgical procedures. Inflammation 2011, 34(5):367–370. 10.1007/s10753-010-9243-yPubMedCrossRef

23.

Sund M, Xie L, Kalluri R: The contribution of vascular basement membranes and extracellular matrix to the mechanics of tumor angiogenesis. APMIS 2004, 112(7-8):450–462. 10.1111/j.1600-0463.2004.t01-1-apm11207-0806.xPubMedCrossRef

24.

Ramazani M, Lundin C, Sund M: Increased circulating levels of basement-membrane components in patients with abdominal aortic aneurysms - a pilot study. Eur J Vasc Endovasc Surg 2011, 42(4):484–487. 10.1016/j.ejvs.2011.05.021PubMedCrossRef

25.

Sund M, Kalluri R: Tumor stroma derived biomarkers in cancer. Cancer Metastasis Rev 2009, 28(1-2):177–183. 10.1007/s10555-008-9175-2PubMedPubMedCentralCrossRef

Title: Elective orthopedic and cardiopulmonary bypass surgery causes a reduction in serum endostatin levels
Authors: Torbjörn Åkerfeldt
Lena Gunningberg
Christine Leo Swenne
Göran Ronquist
Anders Larsson
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: European Journal of Medical Research / Issue 1/2014
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/s40001-014-0061-9

At a glance: The STEP trials

Springer Medicine

Elective orthopedic and cardiopulmonary bypass surgery causes a reduction in serum endostatin levels

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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