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Tumor Biology
Published in: Tumor Biology 5/2014

01-05-2014 | Research Article

Elastography for the differentiation of benign and malignant liver lesions: a meta-analysis

Authors: Xuelei Ma, Wenli Zhan, Binglan Zhang, Benling Wei, Xin Wu, Min Zhou, Lei Liu, Ping Li

Published in: Tumor Biology | Issue 5/2014

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Abstract

The objective of this paper was to evaluate the overall accuracy of elastography in the diagnosis of benign and malignant liver lesions by liver biopsy as the gold standard. Literature databases were searched. The studies which were related to evaluate the diagnostic value of elastography for differentiation in benign and malignant liver lesions in English or Chinese were included. The summary receiver operating characteristic (SROC) curve was performed, and the areas under the curve (AUC) were also calculated to present the accuracy of the elastography for the diagnosis of benign and malignant liver lesions. Six studies which included a total of 448 liver lesions in 384 patients were analyzed. The summary sensitivity and specificity of elastography for the differentiation of malignant liver lesions were 85 % (95 % CI, 80 to 89 %) and 84 % (95 % CI, 80 to 88 %), respectively. And the summary diagnostic odds ratio was 46.33 (95 % CI, 15.22 to 141.02), and the SROC was 0.9328. Elastography has a high sensitivity and specificity differentiation for benign and malignant liver lesions. As a non-invasive method, it is promising to be applied to clinical practice. To estimate elastography objectively, a large, prospective, international, and multi-center study is still needed.
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Metadata
Title
Elastography for the differentiation of benign and malignant liver lesions: a meta-analysis
Authors
Xuelei Ma
Wenli Zhan
Binglan Zhang
Benling Wei
Xin Wu
Min Zhou
Lei Liu
Ping Li
Publication date
01-05-2014
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 5/2014
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-013-1591-4

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