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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2014

Open Access 01-12-2014 | Meeting abstract

EHMTI-0096. Efficacy of sumatriptan: assessment of a possible biomarker

Authors: K Ibrahimi, AH Danser, AH van den Meiracker, A MaassenVanDenBrink

Published in: The Journal of Headache and Pain | Special Issue 1/2014

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Excerpt

Sumatriptan is a frequently applied anti-migraine treatment, yet ≈20-30% migraineurs are nonresponders. TRPV1 channels on trigeminal nerve endings release CGRP during migraine attacks, while, supposedly, stimulation of the presynaptic 5-HT(1B)/1D receptor by sumatriptan inhibits this release. Capsaicin (CAP) stimulates TRPV1 channels, causing CGRP-dependent vasodilatation, whereas electrical stimulation (ES) induces vasodilation without direct TRPV1 activation. …
Metadata
Title
EHMTI-0096. Efficacy of sumatriptan: assessment of a possible biomarker
Authors
K Ibrahimi
AH Danser
AH van den Meiracker
A MaassenVanDenBrink
Publication date
01-12-2014
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue Special Issue 1/2014
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/1129-2377-15-S1-G16

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