Published in:
Open Access
01-12-2014 | Meeting abstract
EHMTI-0062. Expression of fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) in the trigeminal ganglia: implications for craniofacial nociception
Authors:
P Gazerani, BE Cairns, XD Dong
Published in:
The Journal of Headache and Pain
|
Special Issue 1/2014
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Excerpt
Evidence indicates that fractalkine (CX3CL1) and its receptor CX3CR1 are involved in the pathogenesis of pain. Within the central nervous system, CX3CL1 is expressed by neurons and CX3CR1 by microglia. This unique pattern of expression has supported the idea of neuron to glia communication, which is thought to be disregulated under pathological pain conditions. The presence of CX3CL1 and CX3CR1 in trigeminal ganglion (TG) neurons and satellite glial cells (SGCs) and their contribution to nociceptive signal transmission have not been well documented. …