EGFR Mutation in Patients with Lung Adenosquamous Cell Carcinoma

Excerpt

With great interest, we read the article by Moridomi et al. on clinical significance of detecting somatic gene mutations in surgically resected adenosquamous cell carcinoma of the lung in Japanese patients.1 Moridomi et al. reported clinical significance of detecting somatic gene mutations in surgically resected adenosquamous cell carcinoma (ADSQCC) of the lung in Japanese patients. The authors reported that 21.9% of 32 ADSQCC patients had EGFR mutation, but they did not show the positive rate in adenocarcinoma patients in their study period. Was the positive rate in ADSQCC patients almost the same as that in adenocarcinoma patients? The authors reported relapse-free and overall survival in ADSQCC patients. Please let us know whether there was a relationship between these survivals and the ratio of adenocarcinoma and squamous cell carcinoma components. …