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Gynecological Surgery

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Open Access 01-02-2012 | Original Article

Efficacy of polyethylene glycol adhesion barrier after gynecological laparoscopic surgery

Results of a randomized controlled pilot study

Authors: R. P. G. ten Broek, N. Kok-Krant, H. R. Verhoeve, H. van Goor, E. A. Bakkum

Published in: Gynecological Surgery | Issue 1/2012

Abstract

Postoperative adhesions are the most frequent complication of peritoneal surgery, causing small bowel obstruction, female infertility and chronic pain. This pilot study assessed the efficacy of a sprayable polyethylene glycol (PEG) barrier in the prevention of de novo adhesions. 16 patients undergoing laparoscopic gynecological surgery were randomly assigned by shuffled sealed envelopes to receive either the adhesion barrier or no adhesion prevention. Incidence and severity of adhesions were scored at eight sites in the pelvis and reassessed by second look laparoscopy. Adhesion prevention was considered successful if no de novo adhesion were found at second look laparoscopy. One patient was excluded before randomization. Nine patients were randomized to treatment and six patients to control group. De novo adhesions were found in 0/9 patients who received the PEG barrier compared to 4/6 without adhesion prevention (0% vs. 67%, P = 0.01). Reduction in adhesion score was significantly greater in patients receiving PEG barrier (−2.6 vs. −0.06, P = 0.03). Meta-analysis of three randomized trials demonstrated that PEG barrier reduces the incidence of adhesions (odds ratio [OR] = 0.27; 95% CI 0.11–0.67). From this study, PEG barrier seems effective in reducing postoperative formation of de novo adhesions.

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Title: Efficacy of polyethylene glycol adhesion barrier after gynecological laparoscopic surgery
Results of a randomized controlled pilot study
Authors: R. P. G. ten Broek
N. Kok-Krant
H. R. Verhoeve
H. van Goor
E. A. Bakkum
Publication date: 01-02-2012
Publisher: Springer-Verlag
Published in: Gynecological Surgery / Issue 1/2012
Print ISSN: 1613-2076
Electronic ISSN: 1613-2084
DOI: https://doi.org/10.1007/s10397-011-0698-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Efficacy of polyethylene glycol adhesion barrier after gynecological laparoscopic surgery

Results of a randomized controlled pilot study

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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