Skip to main content
Top
Published in: BMC Psychiatry 1/2019

Open Access 01-12-2019 | Research article

Efficacy of Mentalization-based group therapy for adolescents: the results of a pilot randomised controlled trial

Authors: Helen Griffiths, Fiona Duffy, Louise Duffy, Sarah Brown, Harriet Hockaday, Emma Eliasson, Jessica Graham, Julie Smith, Alice Thomson, Matthias Schwannauer

Published in: BMC Psychiatry | Issue 1/2019

Login to get access

Abstract

Background

Mentalization Based Therapy (MBT) has yielded promising outcomes for reducing self-harm, although to date only one study has reported MBT’s effectiveness for adolescents (Rossouw and Fonagy, J Am Acad Child Adolesc Psychiatry 51:1304–1313, 2012) wherein the treatment protocol consisted of an intensive programme of individual and family therapy. We sought to investigate an adaptation of the adult MBT introductory manual in a group format for adolescents.

Methods

The present study is a randomised controlled single blind feasibility trial that aims to (1) adapt the original explicit MBT introductory group manual for an adolescent population (MBT-Ai) and to (2) assess the feasibility of a trial of MBT-Ai through examination of consent rates, attendance, attrition and self-harm. Repeated measures ANOVAs were conducted to examine change over time in independent and dependent variables between groups, and multi level models (MLM) were conducted to examine key predictors in relation to change over time with self-report self-harm and emergency department presentation for harm as the primary outcome variables.

Results

Fifty-three young people consented to participate and were randomised to MBT-Ai + TAU or TAU alone. Five participants withdrew from the trial. Trial procedures seemed appropriate and safe, with acceptable group attendance. Self-reported self-harm and emergency department presentation for self-harm significantly decreased over time in both groups, though there were no between group differences. Social anxiety, emotion regulation, and borderline traits also significantly decreased over time in both groups. Mentalization emerged as a significant predictor of change over time in self reported self harm and hospital presentation for self-harm.

Conclusions

It was feasible to carry out an RCT of MBT-Ai for adolescents already attending NHS CAMHS who have recently self-harmed. Our data gave signals that suggested a relatively brief group-based MBT-Ai intervention may be a promising intervention with potential for service implementation. Future research should consider the appropriate format, dosage and intensity of MBT for the adolescent population.

Trial registration

NCT02771691; Trial Registration Date: 25/04/2016.
Literature
1.
go back to reference Chan MKY, Bhatti H, Meader N, Stockton S, Evans J, O'Connor RC, Kapur N, Kendall T. Predicting suicide following self-harm: systematic review of risk factors and risk scales. Br J Psychiatry. 2016;209(4):277–83. Chan MKY, Bhatti H, Meader N, Stockton S, Evans J, O'Connor RC, Kapur N, Kendall T. Predicting suicide following self-harm: systematic review of risk factors and risk scales. Br J Psychiatry. 2016;209(4):277–83.
2.
go back to reference Hawton K, Harriss L. Deliberate self-harm by under-15-year-olds: characteristics, trends and outcome. J Child Psychol Psychiatry. 2008;49(4):441–8.PubMed Hawton K, Harriss L. Deliberate self-harm by under-15-year-olds: characteristics, trends and outcome. J Child Psychol Psychiatry. 2008;49(4):441–8.PubMed
3.
go back to reference O'Connor RC, Wetherall K, Cleare S, Eschle S, Drummond J, Ferguson E, O'Connor DB, O'Carroll RE. Suicide attempts and non-suicidal self-harm: national prevalence study of young adults. BJPsych open. 2018;4(3):142.PubMedPubMedCentral O'Connor RC, Wetherall K, Cleare S, Eschle S, Drummond J, Ferguson E, O'Connor DB, O'Carroll RE. Suicide attempts and non-suicidal self-harm: national prevalence study of young adults. BJPsych open. 2018;4(3):142.PubMedPubMedCentral
4.
go back to reference Hawton K, Saunders KEA, O'Connor RC. Self-harm and suicide in adolescents. Lancet. 2012;379(9834):2373–82.PubMed Hawton K, Saunders KEA, O'Connor RC. Self-harm and suicide in adolescents. Lancet. 2012;379(9834):2373–82.PubMed
5.
go back to reference Borschmann R, Becker D, Coffey C, Spry E, Moreno-Betancur M, Moran P, Patton GC. 20-year outcomes in adolescents who self-harm: a population-based cohort study. Lancet Child Adolesc Health. 2017;1(3):195–202.PubMed Borschmann R, Becker D, Coffey C, Spry E, Moreno-Betancur M, Moran P, Patton GC. 20-year outcomes in adolescents who self-harm: a population-based cohort study. Lancet Child Adolesc Health. 2017;1(3):195–202.PubMed
6.
go back to reference Jacobson CM, Muehlenkamp JJ, Miller AL, Turner JB. Psychiatric impairment among adolescents engaging in different types of deliberate self-harm. J Clin Child Adolesc Psychol. 2008;37(2):363–75.PubMed Jacobson CM, Muehlenkamp JJ, Miller AL, Turner JB. Psychiatric impairment among adolescents engaging in different types of deliberate self-harm. J Clin Child Adolesc Psychol. 2008;37(2):363–75.PubMed
7.
go back to reference Gould MS, Greenberg TED, Velting DM, Shaffer D. Youth suicide risk and preventive interventions: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry. 2003;42(4):386–405.PubMed Gould MS, Greenberg TED, Velting DM, Shaffer D. Youth suicide risk and preventive interventions: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry. 2003;42(4):386–405.PubMed
8.
go back to reference Luoma JB, Martin CE, Pearson JL. Contact with mental health and primary care providers before suicide: a review of the evidence. Am J Psychiatr. 2002;159(6):909–16.PubMed Luoma JB, Martin CE, Pearson JL. Contact with mental health and primary care providers before suicide: a review of the evidence. Am J Psychiatr. 2002;159(6):909–16.PubMed
9.
go back to reference Crowell SE, Beauchaine TP, Hsiao RC, Vasilev CA, Yaptangco M, Linehan MM, McCauley E. Differentiating adolescent self-injury from adolescent depression: possible implications for borderline personality development. J Abnorm Child Psychol. 2012;40(1):45–57.PubMedPubMedCentral Crowell SE, Beauchaine TP, Hsiao RC, Vasilev CA, Yaptangco M, Linehan MM, McCauley E. Differentiating adolescent self-injury from adolescent depression: possible implications for borderline personality development. J Abnorm Child Psychol. 2012;40(1):45–57.PubMedPubMedCentral
10.
go back to reference Mikolajczak M, Petrides KV, Hurry J. Adolescents choosing self-harm as an emotion regulation strategy: the protective role of trait emotional intelligence. Br J Clin Psychol. 2009;48(2):181–93.PubMed Mikolajczak M, Petrides KV, Hurry J. Adolescents choosing self-harm as an emotion regulation strategy: the protective role of trait emotional intelligence. Br J Clin Psychol. 2009;48(2):181–93.PubMed
11.
go back to reference Allen JG, Fonagy P, Bateman AW. Mentalizing in clinical practice: american psychiatric pub; 2008. Allen JG, Fonagy P, Bateman AW. Mentalizing in clinical practice: american psychiatric pub; 2008.
12.
go back to reference Bateman A, Fonagy P. Mentalization-based treatment for borderline personality disorder: a practical guide. Oxford: Oxford University Press; 2006. Bateman A, Fonagy P. Mentalization-based treatment for borderline personality disorder: a practical guide. Oxford: Oxford University Press; 2006.
13.
go back to reference Rossouw TI, Fonagy P. Mentalization-based treatment for self-harm in adolescents: a randomized controlled trial. J Am Acad Child Adolesc Psychiatry. 2012;51(12):1304–13.PubMed Rossouw TI, Fonagy P. Mentalization-based treatment for self-harm in adolescents: a randomized controlled trial. J Am Acad Child Adolesc Psychiatry. 2012;51(12):1304–13.PubMed
14.
go back to reference Pompili M, Innamorati M, Erbuto D, Amore M, Girardi P. Deficits in mentalization predict suicide risk among psychiatric inpatients. Eur Psychiatry. 2017;41:S264–5. Pompili M, Innamorati M, Erbuto D, Amore M, Girardi P. Deficits in mentalization predict suicide risk among psychiatric inpatients. Eur Psychiatry. 2017;41:S264–5.
15.
go back to reference Burns J, Dudley M, Hazell P, Patton G. Clinical management of deliberate self-harm in young people: the need for evidence-based approaches to reduce repetition. Aust N Z J Psychiatry. 2005;39(3):121–8.PubMed Burns J, Dudley M, Hazell P, Patton G. Clinical management of deliberate self-harm in young people: the need for evidence-based approaches to reduce repetition. Aust N Z J Psychiatry. 2005;39(3):121–8.PubMed
16.
go back to reference De Silva S, Parker A, Purcell R, Callahan P, Liu P, Hetrick S. Mapping the evidence of prevention and intervention studies for suicidal and self-harming behaviors in young people. Crisis. 2013;34(4):223–32. De Silva S, Parker A, Purcell R, Callahan P, Liu P, Hetrick S. Mapping the evidence of prevention and intervention studies for suicidal and self-harming behaviors in young people. Crisis. 2013;34(4):223–32.
17.
go back to reference Hawton K, Witt KG, Salisbury TLT, Arensman E, Gunnell D, Townsend E, van Heeringen K, Hazell P. Interventions for self-harm in children and adolescents. BJPsych Adv. 2016;22(5):286. Hawton K, Witt KG, Salisbury TLT, Arensman E, Gunnell D, Townsend E, van Heeringen K, Hazell P. Interventions for self-harm in children and adolescents. BJPsych Adv. 2016;22(5):286.
18.
go back to reference Ougrin D, Tranah T, Leigh E, Taylor L, Asarnow JR. Practitioner review: self-harm in adolescents. J Child Psychol Psychiatry. 2012;53(4):337–50.PubMed Ougrin D, Tranah T, Leigh E, Taylor L, Asarnow JR. Practitioner review: self-harm in adolescents. J Child Psychol Psychiatry. 2012;53(4):337–50.PubMed
19.
go back to reference Ougrin D, Tranah T, Stahl D, Moran P, Asarnow JR. Therapeutic interventions for suicide attempts and self-harm in adolescents: systematic review and meta-analysis. J Am Acad Child Adolesc Psychiatry. 2015;54(2):97–107.e102.PubMed Ougrin D, Tranah T, Stahl D, Moran P, Asarnow JR. Therapeutic interventions for suicide attempts and self-harm in adolescents: systematic review and meta-analysis. J Am Acad Child Adolesc Psychiatry. 2015;54(2):97–107.e102.PubMed
20.
go back to reference Bateman A, Fonagy P. Mentalization based treatment for borderline personality disorder. World Psychiatry. 2010;9(1):11–5.PubMedPubMedCentral Bateman A, Fonagy P. Mentalization based treatment for borderline personality disorder. World Psychiatry. 2010;9(1):11–5.PubMedPubMedCentral
21.
go back to reference Bateman A, Fonagy P. Effectiveness of partial hospitalization in the treatment of borderline personality disorder: a randomized controlled trial. Am J Psychiatr. 1999;156(10):1563–9.PubMed Bateman A, Fonagy P. Effectiveness of partial hospitalization in the treatment of borderline personality disorder: a randomized controlled trial. Am J Psychiatr. 1999;156(10):1563–9.PubMed
22.
go back to reference Bateman A, Fonagy P. Treatment of borderline personality disorder with psychoanalytically oriented partial hospitalization: an 18-month follow-up. Am J Psychiatr. 2001;158(1):36–42.PubMed Bateman A, Fonagy P. Treatment of borderline personality disorder with psychoanalytically oriented partial hospitalization: an 18-month follow-up. Am J Psychiatr. 2001;158(1):36–42.PubMed
23.
go back to reference Bateman A, Fonagy P. Randomized controlled trial of outpatient mentalization-based treatment versus structured clinical management for borderline personality disorder. Am J Psychiatry. 2009;166(12):1355–64.PubMed Bateman A, Fonagy P. Randomized controlled trial of outpatient mentalization-based treatment versus structured clinical management for borderline personality disorder. Am J Psychiatry. 2009;166(12):1355–64.PubMed
24.
go back to reference Bo S, Sharp C, Beck E, Pedersen J, Gondan M, Simonsen E. First empirical evaluation of outcomes for mentalization-based group therapy for adolescents with BPD. Personal Disord Theory Res Treat. 2017;8(4):396. Bo S, Sharp C, Beck E, Pedersen J, Gondan M, Simonsen E. First empirical evaluation of outcomes for mentalization-based group therapy for adolescents with BPD. Personal Disord Theory Res Treat. 2017;8(4):396.
25.
go back to reference Karterud S. Manual for mentaliseringsbasert psykoedukativ gruppeterapi (MBT-I): Gyldendal akademisk; 2011. Karterud S. Manual for mentaliseringsbasert psykoedukativ gruppeterapi (MBT-I): Gyldendal akademisk; 2011.
26.
go back to reference Chan A-W, Tetzlaff JM, Altman DG, Laupacis A, Gøtzsche PC, Krleža-Jerić K, Hróbjartsson A, Mann H, Dickersin K, Berlin JA. SPIRIT 2013 statement: defining standard protocol items for clinical trials. Ann Intern Med. 2013;158(3):200–7.PubMedPubMedCentral Chan A-W, Tetzlaff JM, Altman DG, Laupacis A, Gøtzsche PC, Krleža-Jerić K, Hróbjartsson A, Mann H, Dickersin K, Berlin JA. SPIRIT 2013 statement: defining standard protocol items for clinical trials. Ann Intern Med. 2013;158(3):200–7.PubMedPubMedCentral
28.
go back to reference Bevington D, Fuggle P, Fonagy P, Target M, Asen E. Innovations in practice: adolescent Mentalization-based integrative therapy (AMBIT)–a new integrated approach to working with the most hard to reach adolescents with severe complex mental health needs. Child Adolesc Mental Health. 2013;18(1):46–51. Bevington D, Fuggle P, Fonagy P, Target M, Asen E. Innovations in practice: adolescent Mentalization-based integrative therapy (AMBIT)–a new integrated approach to working with the most hard to reach adolescents with severe complex mental health needs. Child Adolesc Mental Health. 2013;18(1):46–51.
29.
go back to reference Witt K, de Moraes DP, Salisbury TT, Arensman E, Gunnell D, Hazell P, Townsend E, van Heeringen K, Hawton K. Treatment as usual (TAU) as a control condition in trials of cognitive behavioural-based psychotherapy for self-harm: impact of content and quality on outcomes in a systematic review. J Affect Disord. 2018;235:434–47.PubMed Witt K, de Moraes DP, Salisbury TT, Arensman E, Gunnell D, Hazell P, Townsend E, van Heeringen K, Hawton K. Treatment as usual (TAU) as a control condition in trials of cognitive behavioural-based psychotherapy for self-harm: impact of content and quality on outcomes in a systematic review. J Affect Disord. 2018;235:434–47.PubMed
30.
go back to reference Beecham JK, Knapp MRJ. Costing psychiatric options. In: Thorneycroft G, Brewin C, Wing J, editors. Measuring Mental Health Needs. Oxford: Oxford University Press; 1992. Beecham JK, Knapp MRJ. Costing psychiatric options. In: Thorneycroft G, Brewin C, Wing J, editors. Measuring Mental Health Needs. Oxford: Oxford University Press; 1992.
31.
go back to reference Vrouva I, Fonagy P, Fearon PRM, Roussow T. The risk-taking and self-harm inventory for adolescents: development and psychometric evaluation. Psychol Assess. 2010;22(4):852.PubMed Vrouva I, Fonagy P, Fearon PRM, Roussow T. The risk-taking and self-harm inventory for adolescents: development and psychometric evaluation. Psychol Assess. 2010;22(4):852.PubMed
32.
go back to reference Chorpita BF, Yim L, Moffitt C, Umemoto LA, Francis SE. Assessment of symptoms of DSM-IV anxiety and depression in children: a revised child anxiety and depression scale. Behav Res Ther. 2000;38(8):835–55.PubMed Chorpita BF, Yim L, Moffitt C, Umemoto LA, Francis SE. Assessment of symptoms of DSM-IV anxiety and depression in children: a revised child anxiety and depression scale. Behav Res Ther. 2000;38(8):835–55.PubMed
33.
go back to reference Chorpita BF, Moffitt CE, Gray J. Psychometric properties of the revised child anxiety and depression scale in a clinical sample. Behav Res Ther. 2005;43(3):309–22.PubMed Chorpita BF, Moffitt CE, Gray J. Psychometric properties of the revised child anxiety and depression scale in a clinical sample. Behav Res Ther. 2005;43(3):309–22.PubMed
34.
go back to reference Piqueras JA, Martín-Vivar M, Sandin B, San Luis C, Pineda D. The revised child anxiety and depression scale: a systematic review and reliability generalization meta-analysis. J Affect Disord. 2017;218:153–69.PubMed Piqueras JA, Martín-Vivar M, Sandin B, San Luis C, Pineda D. The revised child anxiety and depression scale: a systematic review and reliability generalization meta-analysis. J Affect Disord. 2017;218:153–69.PubMed
35.
go back to reference Van Oort FVA, Greaves-Lord K, Verhulst FC, Ormel J, Huizink AC. The developmental course of anxiety symptoms during adolescence: the TRAILS study. J Child Psychol Psychiatry. 2009;50(10):1209–17.PubMed Van Oort FVA, Greaves-Lord K, Verhulst FC, Ormel J, Huizink AC. The developmental course of anxiety symptoms during adolescence: the TRAILS study. J Child Psychol Psychiatry. 2009;50(10):1209–17.PubMed
36.
go back to reference Ha C, Sharp C, Ensink K, Fonagy P, Cirino P. The measurement of reflective function in adolescents with and without borderline traits. J Adolesc. 2013;36(6):1215–23.PubMed Ha C, Sharp C, Ensink K, Fonagy P, Cirino P. The measurement of reflective function in adolescents with and without borderline traits. J Adolesc. 2013;36(6):1215–23.PubMed
37.
go back to reference Gratz KL, Roemer L. Multidimensional assessment of emotion regulation and dysregulation: development, factor structure, and initial validation of the difficulties in emotion regulation scale. J Psychopathol Behav Assess. 2004;26(1):41–54. Gratz KL, Roemer L. Multidimensional assessment of emotion regulation and dysregulation: development, factor structure, and initial validation of the difficulties in emotion regulation scale. J Psychopathol Behav Assess. 2004;26(1):41–54.
38.
go back to reference Weinberg A, Klonsky ED. Measurement of emotion dysregulation in adolescents. Psychol Assess. 2009;21(4):616.PubMed Weinberg A, Klonsky ED. Measurement of emotion dysregulation in adolescents. Psychol Assess. 2009;21(4):616.PubMed
39.
go back to reference Boyce P, Parker G. Development of a scale to measure interpersonal sensitivity. Aust N Z J Psychiatry. 1989;23(3):341–51.PubMed Boyce P, Parker G. Development of a scale to measure interpersonal sensitivity. Aust N Z J Psychiatry. 1989;23(3):341–51.PubMed
40.
go back to reference Harb GC, Heimberg RG, Fresco DM, Schneier FR, Liebowitz MR. The psychometric properties of the interpersonal sensitivity measure in social anxiety disorder. Behav Res Ther. 2002;40(8):961–79.PubMed Harb GC, Heimberg RG, Fresco DM, Schneier FR, Liebowitz MR. The psychometric properties of the interpersonal sensitivity measure in social anxiety disorder. Behav Res Ther. 2002;40(8):961–79.PubMed
41.
go back to reference Sharp C, Steinberg L, Temple J, Newlin E. An 11-item measure to assess borderline traits in adolescents: refinement of the BPFSC using IRT. Personal Disord Theory Res Treat. 2014;5(1):70. Sharp C, Steinberg L, Temple J, Newlin E. An 11-item measure to assess borderline traits in adolescents: refinement of the BPFSC using IRT. Personal Disord Theory Res Treat. 2014;5(1):70.
42.
go back to reference Brenning K, Van Petegem S, Vanhalst J, Soenens B. The psychometric qualities of a short version of the experiences in close relationships scale–revised child version. Personal Individ Differ. 2014;68:118–23. Brenning K, Van Petegem S, Vanhalst J, Soenens B. The psychometric qualities of a short version of the experiences in close relationships scale–revised child version. Personal Individ Differ. 2014;68:118–23.
43.
go back to reference Cottrell DJ, Wright-Hughes A, Collinson M, Boston P, Eisler I, Fortune S, Graham EH, Green J, House AO, Kerfoot M. Effectiveness of systemic family therapy versus treatment as usual for young people after self-harm: a pragmatic, phase 3, multicentre, randomised controlled trial. Lancet Psychiatry. 2018;5(3):203–16.PubMedPubMedCentral Cottrell DJ, Wright-Hughes A, Collinson M, Boston P, Eisler I, Fortune S, Graham EH, Green J, House AO, Kerfoot M. Effectiveness of systemic family therapy versus treatment as usual for young people after self-harm: a pragmatic, phase 3, multicentre, randomised controlled trial. Lancet Psychiatry. 2018;5(3):203–16.PubMedPubMedCentral
44.
go back to reference Beck E, Bo S, Gondan M, Poulsen S, Pedersen L, Pedersen J, Simonsen E. Mentalization-based treatment in groups for adolescents with borderline personality disorder (BPD) or subthreshold BPD versus treatment as usual (M-GAB): study protocol for a randomized controlled trial. Trials. 2016;17(1):314.PubMedPubMedCentral Beck E, Bo S, Gondan M, Poulsen S, Pedersen L, Pedersen J, Simonsen E. Mentalization-based treatment in groups for adolescents with borderline personality disorder (BPD) or subthreshold BPD versus treatment as usual (M-GAB): study protocol for a randomized controlled trial. Trials. 2016;17(1):314.PubMedPubMedCentral
Metadata
Title
Efficacy of Mentalization-based group therapy for adolescents: the results of a pilot randomised controlled trial
Authors
Helen Griffiths
Fiona Duffy
Louise Duffy
Sarah Brown
Harriet Hockaday
Emma Eliasson
Jessica Graham
Julie Smith
Alice Thomson
Matthias Schwannauer
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2019
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-019-2158-8

Other articles of this Issue 1/2019

BMC Psychiatry 1/2019 Go to the issue