Top

Published in:

01-12-2015 | Mgmt. of Complex Cases in GI Oncology

Efficacy and Safety of Weekly Paclitaxel Therapy for Advanced Gastric Cancer Patients with Disseminated Intravascular Coagulation

Authors: Sadayuki Kawai, Yasuhiro Sakamoto, Yoshikazu Takahashi, Sonoko Ichikawa, Makio Gamoh

Published in: Journal of Gastrointestinal Cancer | Issue 4/2015

Excerpt

Disseminated intravascular coagulation (DIC) is a severe complication in which various underlying diseases pathologically activate the coagulation system. DIC is characterized by consumptive coagulopathy with severe bleeding, and subsequent multiple thrombi in microvessels can induce organ failure [1]. DIC is rarely associated with solid tumors and occurs in only approximately 10 % of patients between the time of diagnosis of the solid tumor and death [2]. …

Levi M, Ten Cate H. Disseminated intravascular coagulation. N Engl J Med. 1999;341:586–92.CrossRefPubMed

Okajima K, Sakamoto Y, Uchiba M. Heterogeneity in the incidence and clinical manifestations of disseminated intravascular coagulation: a study of 204 cases. Am J Hematol. 2000;65:215–22.CrossRefPubMed

Sallah S, Wan JY, Nguyen NP, Hanrahan LR, Sigounas G. Disseminated intravascular coagulation in solid tumors: clinical and pathologic study. Thromb Haemost. 2001;86:828–33.PubMed

Chao Y, Teng HC, Hung HC, et al. Successful initial treatment with weekly etoposide, epirubicin, cisplatin, 5-fluorouracil and leucovorin chemotherapy in advanced gastric cancer patients with disseminated intravascular coagulation. Jpn J Clin Oncol. 2000;30:122–5.CrossRefPubMed

Takashima A, Shirao K, Hirashima Y, et al. Sequential chemotherapy with methotrexate and 5-fluorouracil for chemotherapy-naive advanced gastric cancer with disseminated intravascular coagulation at initial diagnosis. J Cancer Res Clin Oncol. 2010;136:243–8.CrossRefPubMed

Huang TC, Yeh KH, Cheng AL, Hsu CH. Weekly 24-hour infusional 5-fluorouracil as initial treatment for advanced gastric cancer with acute disseminated intravascular coagulation. Anticancer Res. 2008;28:1293–7.PubMed

Hironaka S, Ueda S, Yasui H, et al. Randomized, open-label, phase III study comparing irinotecan with paclitaxel in patients with advanced gastric cancer without severe peritoneal metastasis after failure of prior combination chemotherapy using fluoropyrimidine plus platinum: WJOG 4007 trial. J Clin Oncol. 2013;31:4438–44.CrossRefPubMed

Chu E, Vincent T, Jr DV. Physicians’ cancer chemotherapy drug manual. Massachusetts: Jones and Bartlett; 2012.

Field KM, Michael M. Part II: liver function in oncology: towards safer chemotherapy use. Lancet Oncol. 2008;9:1181–90.CrossRefPubMed

10.

Kimura A, Kawasaki H, Wajima N, et al. A case of rapidly fatal gastric cancer with disseminated carcinomatosis of the bone marrow. Gan To Kagaku Ryoho. 2013;40:2322–4 (in Japanese).PubMed

11.

Maekawa T. Diagnostic criteria for disseminated intravascular coagulation. Annual report of the Research Committee of Blood Coagulation Disorder, the Ministry of Health and Welfare of Japan. 1980; 5–12 (in Japanese).

12.

Mayumi T, Wada H, Matsushita T, et al. Current clinicians’ medical care for DIC: from the results of questionnaire at the first conference of Tokai DIC up to date. J Jpn Soc Thromb Hemost. 2007;18:619–26 (in Japanese).CrossRef

13.

Pasquini E, Gianni L, Aitini E, et al. Acute disseminated intravascular coagulation syndrome in cancer patients. Oncology. 1995;52:505–8.CrossRefPubMed

14.

Fung WP, Barr A. Fulminant disseminated intravascular coagulation in advanced gastric carcinoma. Am J Gastroenterol. 1979;71:210–2.PubMed

15.

Rhee J, Han SW, Oh DY, et al. Clinicopathologic features and clinical outcomes of gastric cancer that initially presents with disseminated intravascular coagulation: a retrospective study. J Gastroenterol Hepatol. 2010;25:1537–42.CrossRefPubMed

16.

Hwang IG, Choi JH, Park SH, et al. Chemotherapy in advanced gastric cancer patients associated with disseminated intravascular coagulation. Cancer Res Treat. 2014;46:27–32.PubMedCentralCrossRefPubMed

17.

Im CK, Rha SY, Jeung HC, et al. A phase II feasibility study of weekly paclitaxel in heavily pretreated advanced gastric cancer patients with poor performance status. Oncology. 2009;77:349–57.CrossRefPubMed

18.

Jen CJ, Mclntire LV. Platelet microtubules in clot structure formation and contractile force generation: investigation of a controversy. Thromb Haemost. 1986;56:23–7.PubMed

Title: Efficacy and Safety of Weekly Paclitaxel Therapy for Advanced Gastric Cancer Patients with Disseminated Intravascular Coagulation
Authors: Sadayuki Kawai
Yasuhiro Sakamoto
Yoshikazu Takahashi
Sonoko Ichikawa
Makio Gamoh
Publication date: 01-12-2015
Publisher: Springer US
Published in: Journal of Gastrointestinal Cancer / Issue 4/2015
Print ISSN: 1941-6628
Electronic ISSN: 1941-6636
DOI: https://doi.org/10.1007/s12029-015-9744-x

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin

Prof. Florian Limbourg

Prof. Anoop Chauhan

Developed by: Springer Medicine

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 4/2015

Role of Msi1 and MAML1 in Regulation of Notch Signaling Pathway in Patients with Esophageal Squamous Cell Carcinoma

A Unique Coexistence of Colonic Collision and Synchronous Tumors!

Signet Ring Cell Carcinoma of Both Colon and Pancreas

Thrombocytosis and Raised CRP Levels Predicts Advanced Stage in Esophageal Carcinoma

Unusual Case of Squamous Cell Carcinoma of Pancreas with Review of Literature

Impact of Dose Reductions, Delays Between Chemotherapy Cycles, and/or Shorter Courses of Adjuvant Chemotherapy in Stage II and III Colorectal Cancer Patients: a Single-Center Retrospective Study

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

At a glance: The STEP trials