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Published in: Journal of Natural Medicines 4/2007

01-10-2007 | Original Paper

Effects of silkworm powder on glucose absorption by human intestinal epithelial cell line Caco-2

Authors: Junkyu Han, Susumu Inoue, Hiroko Isoda

Published in: Journal of Natural Medicines | Issue 4/2007

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Abstract

Inhibitors of glucose absorption play an important role in the treatment of diabetes. In this research, we report that silkworm powder has inhibitory effects on glucose absorption in human intestinal epithelial cells. Silkworm powder inhibited α-glucosidase activation and glucose transporter (SGLT1) expression. These results suggest that silkworm powder can be used as a natural functional food for the prevention and alleviation of type-2 diabetes.
Literature
1.
go back to reference Wagman AS, Nuss JM (2001) Current therapies and emerging targets for the treatment of diabetes. Curr Pharm Design 7:417–450CrossRef Wagman AS, Nuss JM (2001) Current therapies and emerging targets for the treatment of diabetes. Curr Pharm Design 7:417–450CrossRef
2.
go back to reference Dyer J, Wood IS, Palejwala A, Shirazi-Beechey SP (2002) Expression of monosaccharide transporters in intestine of diabetic human. Am J Physiol 282:G241–G248 Dyer J, Wood IS, Palejwala A, Shirazi-Beechey SP (2002) Expression of monosaccharide transporters in intestine of diabetic human. Am J Physiol 282:G241–G248
3.
go back to reference Ryu KS, Lee HS, Kim IS (2002) Effects and mechanisms of silkworm powder as a blood glucose-lowering agent. Int J Indust Entomol 4:93–100 Ryu KS, Lee HS, Kim IS (2002) Effects and mechanisms of silkworm powder as a blood glucose-lowering agent. Int J Indust Entomol 4:93–100
4.
go back to reference Hashimoto K, Kawagishi H, Nakayama T, Shimizu M (1997) Effect of capsianoside, a diterpene glycoside, on tight-junctional permeability. Biochim Biophys Acta 1323:281–290PubMedCrossRef Hashimoto K, Kawagishi H, Nakayama T, Shimizu M (1997) Effect of capsianoside, a diterpene glycoside, on tight-junctional permeability. Biochim Biophys Acta 1323:281–290PubMedCrossRef
5.
go back to reference Hansawasdi C, Kawabata J, Kasai T (2001) Hibiscus acid as an inhibitor of starch digestion in the Caco-2 cell model system. Biosci Biotechnol Biochem 65:2087–2089PubMedCrossRef Hansawasdi C, Kawabata J, Kasai T (2001) Hibiscus acid as an inhibitor of starch digestion in the Caco-2 cell model system. Biosci Biotechnol Biochem 65:2087–2089PubMedCrossRef
6.
go back to reference Miwa I, Okuda J, Maeda K, Okuda G (1972) Mutarotase effect on colorimetric determination of blood glucose with d-glucose oxidase. Clin Chim Acta 37:538–540PubMedCrossRef Miwa I, Okuda J, Maeda K, Okuda G (1972) Mutarotase effect on colorimetric determination of blood glucose with d-glucose oxidase. Clin Chim Acta 37:538–540PubMedCrossRef
7.
go back to reference Hansawasdi C, Kawabata J, Kasai T (2000) α-Amylase inhibitor from roselle (Hibiscus sabdariffa Linn.) Biosci Biotechnol Biochem 64:1041–1043PubMedCrossRef Hansawasdi C, Kawabata J, Kasai T (2000) α-Amylase inhibitor from roselle (Hibiscus sabdariffa Linn.) Biosci Biotechnol Biochem 64:1041–1043PubMedCrossRef
8.
go back to reference Freeman WM, Walker SJ, Vrana KE (1999) Quantitative RT-PCR: pitfalls and potential. Biotechnology 26:112–125 Freeman WM, Walker SJ, Vrana KE (1999) Quantitative RT-PCR: pitfalls and potential. Biotechnology 26:112–125
9.
go back to reference Asano N, Oseki K, Tomioka E, Kizu H, Matsui K (1994) N-Containing sugars from Morus alba and their glycosidase inhibitory activities. Carbohydr Res 259:243–255PubMedCrossRef Asano N, Oseki K, Tomioka E, Kizu H, Matsui K (1994) N-Containing sugars from Morus alba and their glycosidase inhibitory activities. Carbohydr Res 259:243–255PubMedCrossRef
10.
go back to reference Asano N, Yamashita T, Yasuda K, Ikeda K, Kizu H, Kameda Y, Kato A, Nash RJ, Lee HS, Ryu KS (2001) Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.). J Agric Food Chem 49:4208–4213PubMedCrossRef Asano N, Yamashita T, Yasuda K, Ikeda K, Kizu H, Kameda Y, Kato A, Nash RJ, Lee HS, Ryu KS (2001) Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.). J Agric Food Chem 49:4208–4213PubMedCrossRef
11.
go back to reference Ryu KS, Lee HS, Chung SH, Kang PD (1997) An activity of lowering blood-glucose levels according to preparative conditions of silkworm powder. Korean J Sericult Sci 39:79–85 Ryu KS, Lee HS, Chung SH, Kang PD (1997) An activity of lowering blood-glucose levels according to preparative conditions of silkworm powder. Korean J Sericult Sci 39:79–85
12.
go back to reference Zeuthen T, Zeuthen E, Klaerke DA (2002) Mobility of ions, sugar, and water in the cytoplasm of xenopus oocytes expressing Na(+)-coupled sugar transporters (SGLT1). J Phys 542:71–87CrossRef Zeuthen T, Zeuthen E, Klaerke DA (2002) Mobility of ions, sugar, and water in the cytoplasm of xenopus oocytes expressing Na(+)-coupled sugar transporters (SGLT1). J Phys 542:71–87CrossRef
13.
go back to reference Ikari A, Nakano M, Suketa Y, Harada H, Takagi K (2005) Reorganization of ZO-1 by sodium-dependent glucose transporter activation after heat stress in LLC-PK1 cells. J Cell Physiol 203:471–478PubMedCrossRef Ikari A, Nakano M, Suketa Y, Harada H, Takagi K (2005) Reorganization of ZO-1 by sodium-dependent glucose transporter activation after heat stress in LLC-PK1 cells. J Cell Physiol 203:471–478PubMedCrossRef
14.
go back to reference Ikari A, Nagatani Y, Tsukimoto M, Harada H, Miwa M, Takagi K (2005) Sodium-dependent glucose transporter reduces peroxynitrite and cell injury caused by cisplatin in renal tubular epithelial cells. Biochem Biophys Acta 1717:109–117PubMedCrossRef Ikari A, Nagatani Y, Tsukimoto M, Harada H, Miwa M, Takagi K (2005) Sodium-dependent glucose transporter reduces peroxynitrite and cell injury caused by cisplatin in renal tubular epithelial cells. Biochem Biophys Acta 1717:109–117PubMedCrossRef
Metadata
Title
Effects of silkworm powder on glucose absorption by human intestinal epithelial cell line Caco-2
Authors
Junkyu Han
Susumu Inoue
Hiroko Isoda
Publication date
01-10-2007
Publisher
Springer-Verlag
Published in
Journal of Natural Medicines / Issue 4/2007
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-007-0164-5

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