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01-07-2012 | Clinical Study

Effects of sequential chemotherapy of FOLFIRI/FOLFOX on the endocrine axes of ACTH–cortisol and renin–angiotensin–aldosterone

Authors: Changxin Huang, Yiqian Jiang, Guangliang Duan, Zhaoyang Li, Lingzhi Chen, Xuechun Wang

Published in: Journal of Neuro-Oncology | Issue 3/2012

Abstract

The chemotherapies of FOLFOX (leucovorin + 5-fluorouracil + oxaliplatin) and FOLFIRI (folinic acid + 5-fluorouracil + irinotecan) are effective for a variety of malignant tumors. In particular, the sequential chemotherapy of FOLFOX/FOLFIRI has become the preferred post-operational treatment approach for gastrointestinal cancer and an important palliative care program for advanced cancer. However, the sequential chemotherapy of FOLFOX/FOLFIRI showed severe side effects due to the fact that the toxicity of the drugs can be enhanced by each other. Here, we report the dynamic changes in the activities of serum ACTH, cortisol, renin, angiotensin, and aldosterone in patients following multiple cycles of FOLFOX/FOLFIRI sequential chemotherapy. We found that the sequential chemotherapy might cause damage to the activities of the endocrine cells and/or the sympathetic nerve, and alter endocrine function, specifically the ACTH–cortisol and renin–angiotensin–aldosterone axes.

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Title: Effects of sequential chemotherapy of FOLFIRI/FOLFOX on the endocrine axes of ACTH–cortisol and renin–angiotensin–aldosterone
Authors: Changxin Huang
Yiqian Jiang
Guangliang Duan
Zhaoyang Li
Lingzhi Chen
Xuechun Wang
Publication date: 01-07-2012
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 3/2012
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-012-0845-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effects of sequential chemotherapy of FOLFIRI/FOLFOX on the endocrine axes of ACTH–cortisol and renin–angiotensin–aldosterone

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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