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Journal of Cardiothoracic Surgery

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Open Access 01-12-2008 | Research article

Effects of retinoic acid on compensatory lung growth

Authors: Sami Karapolat, Aydin Sanli, Ahmet Onen, Unal Acikel, Oya Sivrikoz

Published in: Journal of Cardiothoracic Surgery | Issue 1/2008

Abstract

Background

We investigated the effect of Retinoic acid in the growth of contralateral lung after pneumonectomy.

Methods

Twentyone adult male Wistar albino rats from the same colony were used. They were divided into three groups (Group A, B and C). Group A undergone only left posterolateral thoracotomy. In Group B and C, the rats were subjected to left posterolateral thoracotomy and left pneumonectomy. In Group C, rats were given intraperitoneal Retinoic acid during the operation and continued to be given everyday postoperatively. Rats were sacrificed on the 10^th day and their total body, right lung weights and right lung volumes were measured.

Results

The volume and weight indices of the lung were found to be higher in Group C. In histopathological examination, there was a reduction in the mean number of alveoli in Group B and C. A significant rise in the mean dimension and average wall thickness of the alveolar structure were determined in Group C.

Conclusion

Retinoic acid contributes to the compensatory growth of the residual lung tissue.

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Title: Effects of retinoic acid on compensatory lung growth
Authors: Sami Karapolat
Aydin Sanli
Ahmet Onen
Unal Acikel
Oya Sivrikoz
Publication date: 01-12-2008
Publisher: BioMed Central
Published in: Journal of Cardiothoracic Surgery / Issue 1/2008
Electronic ISSN: 1749-8090
DOI: https://doi.org/10.1186/1749-8090-3-37

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effects of retinoic acid on compensatory lung growth

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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