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Archives of Dermatological Research
Published in: Archives of Dermatological Research 5/2017

01-07-2017 | Concise Communication

Effects of palmitoyl-KVK-L-ascorbic acid on skin wrinkles and pigmentation

Authors: Hyeong Mi Kim, Hyo Sun An, Jung-Soo Bae, Jung Yun Kim, Chi Ho Choi, Ju Yeon Kim, Joo Hyuck Lim, Joon-hun Choi, Hyunnam Song, Sung Ho Moon, Young Jun Park, Shin-Jae Chang, Sun Young Choi

Published in: Archives of Dermatological Research | Issue 5/2017

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Abstract

Wrinkle formation and abnormal pigmentation are major clinical alterations associated with skin aging. As the aim of our study was to investigate the effects of palmitoyl-KVK-L-ascorbic acid on skin aging, the anti-wrinkle and depigmentation effects of palmitoyl-KVK-L-ascorbic acid were evaluated by measuring collagen expression in dermal fibroblast cells and inhibition of melanogenesis in B16F1 cells, respectively. The anti-aging effect of palmitoyl-KVK-L-ascorbic acid cream was also evaluated against a placebo cream in a clinical trial. Our results confirmed that the expression of type Ι collagen in dermal fibroblast cells treated with palmitoyl-KVK-L-ascorbic acid (0.1–4 μg/mL) increased in a dose-dependent manner. In B16F1 cells, treatment with 20 μg/mL palmitoyl-KVK-L-ascorbic acid reduced the melanin content by approximately 20% compared to alpha-melanocyte stimulating hormone treatment. In the clinical trial, application of palmitoyl-KVK-L-ascorbic acid cream led to an improvement in skin roughness and lightness in 12 and 8 weeks, respectively. Our data show that palmitoyl-KVK-L-ascorbic acid is an effective anti-aging agent that reduces wrinkles and abnormal skin pigmentation.
Literature
1.
Badenhorst T, Svirskis D, Wu Z (2014) Pharmaceutical strategies for the topical dermal delivery of peptides/proteins for cosmetic and therapeutic applications. Aust J Pharmacol Ther 2(6):1036
2.
Cho JW, Il KJ, Lee KS (2013) Downregulation of type I collagen expression in silibinin-treated human skin fibroblasts by blocking the activation of Smad2/3-dependent signaling pathways: potential therapeutic use in the chemoprevention of keloids. Int J Mol Med 31(5):1148–1152PubMed
3.
Choi HI, Park JI, Kim HJ et al (2009) A novel L-ascorbic acid and peptide conjugate with increased stability and collagen biosynthesis. BMB Rep 42(11):743–746CrossRefPubMed
4.
Chen H, Herndon ME, Lawler J (2000) The cell biology of thrombospondin-1. Matrix Biol 19(7):597–614CrossRefPubMed
5.
Chung JH, Lee SH, Youn CS et al (2001) Cutaneous photodamage in Koreans: influence of sex, sun exposure, smoking, and skin color. Arch Dermatol 137(8):1043–1051PubMed
6.
Fields K, Falla TJ, Rodan K et al (2009) Bioactive peptides: signaling the future. J Cosmetic Dermatol 8(1):8–13CrossRef
7.
Fujinami Y, Tai A, Yamamoto I (2001) Radical Scavenging Activity against 1,1-Diphenyl-2-picrylhydrazyl of Ascorbic Acid 2-Glucoside (AA-2G) and 6-Acyl-AA-2G. Chem Pharm Bull 49(5):642–644CrossRefPubMed
8.
Gorouhi F, Maibach HI (2009) Role of topical peptides in preventing or treating aged skin. Int J Cosmetic Sci 31(5):327–345CrossRef
9.
Jin MH, Park SG, Hwang YL et al (2012) Cedrol enhances extracellular matrix production in dermal fibroblasts in a MAPK-dependent manner. Ann Dermatol 24(1):16–21CrossRefPubMedPubMedCentral
10.
Kim DS, Park SH, Park KC (2004) Transforming growth factor-β1 decreases melanin synthesis via delayed extracellular signal-regulated kinase activation. Int J Biochem Cell B 36(8):1482–1491
11.
Kim WS, Park SH, Ahn SJ et al (2008) Whitening effect of adipose-derived stem cells: a critical role of TGF-β1. Biol Pharm Bull 31(4):606–610CrossRefPubMed
12.
Kumano Y, Sakamoto T, Egawa M et al (1998) In vitro and In vivo Prolonged Biological Activities of Novel Vitamin C Derivative, 2-O-α-D-Glucopyranosyl-L-Ascorbic Acid (AA-2G), in Cosmetic Fields. J Nutr Sci Vitaminol 44(3):345–359CrossRefPubMed
13.
Lu C, Kim BM, Lee D et al (2013) Synthesis of lipoic acidepeptide conjugates and their effect on collagen and melanogenesis. Eur J Med Chem 69:449–454CrossRefPubMed
14.
Murphy-Ullrich JE, Poczatek M (2000) Activation of latent TGF-β by thrombospondin-1: mechanisms and physiology. Cytokine Growth Factor Rev 11(1–2):59–69CrossRefPubMed
15.
Murakami M, Matsuzaki F, Funaba M (2009) Regulation of melanin synthesis by the TGF-β family in B16 melanoma cells. Mol Biol Rep 36(6):1247–1250CrossRefPubMed
16.
Martínez-Esparza M, Jiménez-Cervantes C, Beermann F et al (1997) Transforming growth factor-β1 inhibits basal melanogenesis in B16/F10 mouse melanoma cells by increasing the rate of degradation of tyrosinase and tyrosinase-related protein-1. J Biol Chem 272(7):3967–3972CrossRefPubMed
17.
Ochiai Y, Kaburagi S, Obayashi K et al (2006) A new lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), prevents UV-induced skin pigmentation through its anti-oxidative properties. J Dermatol Sci 44(1):37–44CrossRefPubMed
18.
Panich U, Tangsupa-a-nan V, Onkoksoong T et al (2011) Inhibition of UVA-mediated melanogenesis by ascorbic acid through modulation of antioxidant defense and nitric oxide system. Arch Pharm Res 34(5):811–820CrossRefPubMed
19.
Reddy B, Jow T, Mantach BM (2012) Bioactive oligopeptides in dermatology: part I. Exp Dermatol 21(8):563–568CrossRefPubMed
20.
Shibayama H, Hisama M, Matsuda S et al (2008) Effect of a novel ascorbic derivative, disodium isostearyl 2-O-L-ascorbyl phosphate on human dermal fibroblasts: Increased collagen synthesis and inhibition of MMP-1. Biol Pharm Bull 31(4):563–568CrossRefPubMed
21.
Taniguchi M, Arai N, Kohno K et al (2012) Anti-oxidative and anti-aging activities of 2-O-α-glucopyranosyl-L-ascorbic acid on human dermal fibroblasts. Eur J Pharmacol 674(2–3):126–131CrossRefPubMed
22.
Metadata
Title
Effects of palmitoyl-KVK-L-ascorbic acid on skin wrinkles and pigmentation
Authors
Hyeong Mi Kim
Hyo Sun An
Jung-Soo Bae
Jung Yun Kim
Chi Ho Choi
Ju Yeon Kim
Joo Hyuck Lim
Joon-hun Choi
Hyunnam Song
Sung Ho Moon
Young Jun Park
Shin-Jae Chang
Sun Young Choi
Publication date
01-07-2017
Publisher
Springer Berlin Heidelberg
Published in
Archives of Dermatological Research / Issue 5/2017
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI
https://doi.org/10.1007/s00403-017-1731-6

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