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Clinical Oral Investigations
Published in: Clinical Oral Investigations 1/2019

01-01-2019 | Original Article

Effects of non-surgical periodontal therapy on periodontal laboratory and clinical data as well as on disease activity in patients with rheumatoid arthritis

Authors: Raluca Cosgarea, Roxana Tristiu, Raluca Bianca Dumitru, Nicole Birgit Arweiler, Simona Rednic, Cristina Ioana Sirbu, Liana Lascu, Anton Sculean, Sigrun Eick

Published in: Clinical Oral Investigations | Issue 1/2019

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Abstract

Objectives

To compare the effect of non-surgical periodontal therapy on clinical and inflammatory parameters in patients with moderate to severe chronic periodontitis (CP) and rheumatoid arthritis (RA) (RA-CP) with that in CP patients without RA.

Material and methods

Eighteen patients with RA-CP and 18 systemically healthy patients with CP were treated with scaling and root planing (SRP) within 24 h. At baseline, and at 3 and 6 months after SRP, clinical periodontal parameters, inflammatory markers, and microorganisms in subgingival biofilm were assessed. In addition, disease activity markers of RA (DAS28, CRP, ESR) and specific antibodies (RF) were monitored in the RA-CP group.

Results

In both groups, non-surgical therapy yielded to statistically significant improvements in all investigated clinical periodontal variables; in RA patients, a statistically significant decrease in serum-CRP was seen at 3 months. At all time-points, levels of inflammatory markers in GCF were higher in RA-CP than in CP patients. Counts of Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola decreased statistically significantly in CP but not in the RA-CP group. Changes of DAS28 correlated positively with those of P. gingivalis and negatively with the plaque index.

Conclusions

Within their limits, the present data suggest that (a) non-surgical periodontal therapy improves periodontal conditions in CP patients with and without RA and (b) in patients with RA, eradication of P. gingivalis in conjunction with a high level oral hygiene may transiently decrease disease activity of RA.

Clinical relevance

In patients with RA and CP, non-surgical periodontal therapy is a relevant modality not only to improve the periodontal condition but also to decrease RA activity.
Appendix
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Metadata
Title
Effects of non-surgical periodontal therapy on periodontal laboratory and clinical data as well as on disease activity in patients with rheumatoid arthritis
Authors
Raluca Cosgarea
Roxana Tristiu
Raluca Bianca Dumitru
Nicole Birgit Arweiler
Simona Rednic
Cristina Ioana Sirbu
Liana Lascu
Anton Sculean
Sigrun Eick
Publication date
01-01-2019
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 1/2019
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-018-2420-3

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