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01-09-2017 | Original Article

Effects of Nigerian red propolis in rats infected with Trypanosoma brucei brucei

Authors: Nwakaego E. Nweze, Henry O. Okoro, Majed Al Robaian, Ruwida M. K. Omar, Terrumun A. Tor-Anyiin, David G. Watson, John O. Igoli

Published in: Comparative Clinical Pathology | Issue 5/2017

Abstract

Propolis has a long history of use in folk medicine and possesses various biological activities. Effects of the methanol extract of Nigerian red propolis (NRP) in trypanosome-infected rats were studied. Mature albino Wistar rats (30) were randomly grouped into six (A–F). Groups A–E were infected with 1.0 × 10⁶ Trypanosoma brucei brucei organisms intraperitoneally. Group F was uninfected. On establishment of infection, groups A–C were treated orally with NRP at 600, 400 and 200 mg/kg body weight for five consecutive days while group D received diminazene aceturate at 7 mg/kg body weight intraperitoneally. Group E received equal volumes of DMSO solution for five consecutive days. Parameters monitored were mean group parasitaemia, packed cell volumes (PCV), haemoglobin concentrations (Hbc) and bodyweight changes. By day 16 post-infection (PI) parasitaemia was significantly higher in the DMSO control group E than in the NRP-treated groups. Mean group PCV, Hbc and weight loss were significantly (p < 0.05) lower in DMSO control group when compared with all the other experimental groups. Rats treated with NRP (600 and 400 mg/kg) had significant (p < 0.05) reduction in parasitaemia (day 16 PI), higher PCV, Hbc and weight gain than the DMSO control.

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Title: Effects of Nigerian red propolis in rats infected with Trypanosoma brucei brucei
Authors: Nwakaego E. Nweze
Henry O. Okoro
Majed Al Robaian
Ruwida M. K. Omar
Terrumun A. Tor-Anyiin
David G. Watson
John O. Igoli
Publication date: 01-09-2017
Publisher: Springer London
Published in: Comparative Clinical Pathology / Issue 5/2017
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-017-2497-0

At a glance: The STEP trials

Springer Medicine

Effects of Nigerian red propolis in rats infected with Trypanosoma brucei brucei

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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