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Archives of Gynecology and Obstetrics

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01-02-2012 | General Gynecology

Effects of intravaginal estriol and pelvic floor rehabilitation on urogenital aging in postmenopausal women

Authors: Giampiero Capobianco, Ermes Donolo, Gianna Borghero, Francesco Dessole, Pier Luigi Cherchi, Salvatore Dessole

Published in: Archives of Gynecology and Obstetrics | Issue 2/2012

Abstract

Purpose

To assess the effects of the combination of pelvic floor rehabilitation and intravaginal estriol administration on stress urinary incontinence (SUI), urogenital atrophy and recurrent urinary tract infections in postmenopausal women.

Methods

Two-hundred-six postmenopausal women with urogenital aging symptoms were enrolled in this prospective randomized controlled study. Patients were randomly divided into two groups and each group consisted of 103 women. Subjects in the treatment group received intravaginal estriol ovules, such as 1 ovule (1 mg) once daily for 2 weeks and then 2 ovules once weekly for a total of 6 months as maintenance therapy plus pelvic floor rehabilitation. Subjects in the control group received only intravaginal estriol in a similar regimen. We evaluated urogenital symptomatology, urine cultures, colposcopic findings, urethral cytologic findings, urethral pressure profiles and urethrocystometry before, as well as after 6 months of treatment.

Results

After therapy, the symptoms and signs of urogenital atrophy significantly improved in both groups. 61/83 (73.49%) of the treated patients, and only 10/103 (9.71%) of the control patients referred a subjective improvement of their incontinence. In the patients treated by combination therapy with estriol plus pelvic floor rehabilitation, we observed significant improvements of colposcopic findings, and there were statistically significant increases in mean maximum urethral pressure (MUP), in mean urethral closure pressure (MUCP), as well as in the abdominal pressure transmission ratio to the proximal urethra (PTR).

Conclusions

Our results showed that combination therapy with estriol plus pelvic floor rehabilitation was effective and should be considered as a first-line treatment for symptoms of urogenital aging in postmenopausal women.

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Title: Effects of intravaginal estriol and pelvic floor rehabilitation on urogenital aging in postmenopausal women
Authors: Giampiero Capobianco
Ermes Donolo
Gianna Borghero
Francesco Dessole
Pier Luigi Cherchi
Salvatore Dessole
Publication date: 01-02-2012
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 2/2012
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-011-1955-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effects of intravaginal estriol and pelvic floor rehabilitation on urogenital aging in postmenopausal women

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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