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01-06-2007 | Magnetic Resonance

Effects of injection rate and dose on image quality in time-resolved magnetic resonance angiography (MRA) by using 1.0M contrast agents

Authors: Harald Kramer, Henrik J. Michaely, Martin Requardt, Martin Rohrer, Scott Reeder, Maximilian F. Reiser, Stefan O. Schoenberg

Published in: European Radiology | Issue 6/2007

Abstract

In time-resolved MRA (TR MRA), injection parameters and contrast agent (CA) dose are important factors influencing image quality. In this study, three different injection schemes with different CA volumes were evaluated in 12 healthy volunteers. Injection rates between 0.2 and 0.8 ml/s were evaluated with CA volumes of 10 and 20 ml. To measure circulatory parameters, cine cardiac MRI was performed before each exam. Spatial resolution could be reduced to 2×1.4×2 mm³, temporal resolution was 2.25 s/frame. To exclude signal saturation at high CA concentrations, a phantom with fixed CA concentrations was placed in the field of view. SNR was measured, and the area under the curve of the arterial signal of the different injection schemes was calculated. Results showed the largest diagnostic window at a relatively slow injection rate of 0.4 ml/s and a CA volume of 10 ml. Circulatory parameters have an important impact on CA arrival, so delay times have to be set depending on these parameters.

Parfrey P (1989) Contrast material induced renal failure in patients with diabetes mellitus renal insufficiency, or both: a prospective controlled study. N Eng J Med 320:143–149CrossRef

Du J et al (2003) SNR improvement for multiinjection time-resolved high-resolution CE-MRA of the peripheral vasculature. Magn Reson Med 49(5):909–917PubMedCrossRef

Ruehm SG et al (2000) Pelvic and lower extremity arterial imaging: diagnostic performance of three-dimensional contrast-enhanced MR angiography. AJR Am J Roentgenol 174(4):1127–1135PubMed

Schoenberg SO et al (2005) High-spatial-resolution MR angiography of renal arteries with integrated parallel acquisitions: comparison with digital subtraction angiography and US. Radiology 235(2):687–698PubMedCrossRef

Hany TF et al (2001) Aorta and runoff vessels: single-injection MR angiography with automated table movement compared with multiinjection time-resolved MR angiography-initial results. Radiology 221(1):266–272PubMedCrossRef

Du J et al (2004) Contrast-enhanced peripheral magnetic resonance angiography using time-resolved vastly undersampled isotropic projection reconstruction. J Magn Reson Imaging 20(5):894–900PubMedCrossRef

Swan JS et al (2002) Time-resolved three-dimensional contrast-enhanced MR angiography of the peripheral vessels. Radiology 225(1):43–52PubMedCrossRef

Korosec FR et al (1996) Time-resolved contrast-enhanced 3D MR angiography. Magn Reson Med 36(3):345–351PubMedCrossRef

Fink C et al (2005) Time-resolved contrast-enhanced three-dimensional magnetic resonance angiography of the chest: combination of parallel imaging with view sharing (TREAT). Invest Radiol 40(1):40–48PubMed

10.

Gregor M et al (2002) Peripheral run-off CE-MRA with a 1.0 molar gadolinium chelate (Gadovist) with intraarterial DSA comparison. Acad Radiol 9(Suppl 2):S398–S400PubMedCrossRef

11.

Schafer FK et al (2003) First clinical results in a study of contrast enhanced magnetic resonance angiography with the 1.0 molar gadobutrol in peripheral arterial occlusive disease-comparison to intraarterial DSA. Rofo 175(4):556–564PubMed

12.

Carroll TJ et al (2001) The effect of injection rate on time-resolved contrast-enhanced peripheral MRA. J Magn Reson Imaging 14(4):401–410PubMedCrossRef

13.

Korosec FR et al (1999) Contrast-enhanced MR angiography of the carotid bifurcation. J Magn Reson Imaging 10(3):317–325PubMedCrossRef

14.

Watts R et al (2002) Recessed elliptical-centric view-ordering for contrast-enhanced 3D MR angiography of the carotid arteries. Magn Reson Med 48(3):419–424PubMedCrossRef

15.

Hansen MS et al (2004) Accelerated dynamic Fourier velocity encoding by exploiting velocity-spatio-temporal correlations. Magma 17(2):86–94PubMedCrossRef

16.

Tsao J, Boesiger P, Pruessmann KP (2003) k-t BLAST and k-t SENSE: dynamic MRI with high frame rate exploiting spatiotemporal correlations. Magn Reson Med 50(5):1031–1042PubMedCrossRef

17.

Henkelman RM (1985) Measurement of signal intensities in the presence of noise in MR images. Med Phys 12(2):232–233PubMedCrossRef

18.

Constantinides CD, Atalar E, McVeigh ER (1997) Signal-to-noise measurements in magnitude images from NMR phased arrays. Magn Reson Med 38(5):852–857PubMedCrossRef

19.

Reeder SB et al (2005) Practical approaches to the evaluation of signal-to-noise ratio performance with parallel imaging: application with cardiac imaging and a 32-channel cardiac coil. Magn Reson Med 54(3):748–754PubMedCrossRef

20.

Alfakih K et al (2003) Normal human left and right ventricular dimensions for MRI as assessed by turbo gradient echo and steady-state free precession imaging sequences. J Magn Reson Imaging 17(3):323–329PubMedCrossRef

21.

Leiner T et al (2005) Contemporary imaging techniques for the diagnosis of renal artery stenosis. Eur Radiol 15(11):2219–2229PubMedCrossRef

22.

Finn JP et al (2002) Thorax: low-dose contrast-enhanced three-dimensional MR angiography with subsecond temporal resolution-initial results. Radiology 224(3):896–904PubMedCrossRef

23.

Schmitt R et al (2005) Comprehensive MR angiography of the lower limbs: a hybrid dual-bolus approach including the pedal arteries. Eur Radiol 15(12):2513–2524PubMedCrossRef

24.

Prince MR, et al (2002) Contrast material travel times in patients undergoing peripheral MR angiography. Radiology 224(1):55–61PubMedCrossRef

25.

Wang Y, et al (2002) Bolus arterial-venous transit in the lower extremity and venous contamination in bolus chase three-dimensional magnetic resonance angiography. Invest Radiol 37(8):458–463PubMedCrossRef

26.

Huston J III et al (2001) Carotid artery: elliptic centric contrast-enhanced MR angiography compared with conventional angiography. Radiology 218(1):138–143PubMed

27.

Hentsch A et al (2003) Gadobutrol-enhanced moving-table magnetic resonance angiography in patients with peripheral vascular disease: a prospective, multi-centre blinded comparison with digital subtraction angiography. Eur Radiol 13(9):2103–2114PubMedCrossRef

28.

Ziyeh S et al (2005) Dynamic 3D MR angiography of intra- and extracranial vascular malformations at 3T: a technical note. AJNR Am J Neuroradiol 26(3):630–634PubMed

Title: Effects of injection rate and dose on image quality in time-resolved magnetic resonance angiography (MRA) by using 1.0M contrast agents
Authors: Harald Kramer
Henrik J. Michaely
Martin Requardt
Martin Rohrer
Scott Reeder
Maximilian F. Reiser
Stefan O. Schoenberg
Publication date: 01-06-2007
Publisher: Springer-Verlag
Published in: European Radiology / Issue 6/2007
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-006-0493-x

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Effects of injection rate and dose on image quality in time-resolved magnetic resonance angiography (MRA) by using 1.0M contrast agents

Abstract

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Abstract

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