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Open Access 01-12-2008 | Review

Effects of general anesthetics on visceral pain transmission in the spinal cord

Authors: Yun Wang, Jing Wu, Qing Lin, HJ Nauta, Yun Yue, Li Fang

Published in: Molecular Pain | Issue 1/2008

Abstract

Current evidence suggests an analgesic role for the spinal cord action of general anesthetics; however, the cellular population and intracellular mechanisms underlying anti-visceral pain by general anesthetics still remain unclear. It is known that visceral nociceptive signals are transmited via post-synaptic dorsal column (PSDC) and spinothalamic tract (STT) neuronal pathways and that the PSDC pathway plays a major role in visceral nociception. Animal studies report that persistent changes including nociception-associated molecular expression (e.g. neurokinin-1 (NK-1) receptors) and activation of signal transduction cascades (such as the protein kinase A [PKA]-c-AMP-responsive element binding [CREB] cascade)-in spinal PSDC neurons are observed following visceral pain stimulation. The clinical practice of interruption of the spinal PSDC pathway in patients with cancer pain further supports a role of this group of neurons in the development and maintenance of visceral pain. We propose the hypothesis that general anesthetics might affect critical molecular targets such as NK-1 and glutamate receptors, as well as intracellular signaling by CaM kinase II, protein kinase C (PKC), PKA, and MAP kinase cascades in PSDC neurons, which contribute to the neurotransmission of visceral pain signaling. This would help elucidate the mechanism of antivisceral nociception by general anesthetics at the cellular and molecular levels and aid in development of novel therapeutic strategies to improve clinical management of visceral pain.

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Title: Effects of general anesthetics on visceral pain transmission in the spinal cord
Authors: Yun Wang
Jing Wu
Qing Lin
HJ Nauta
Yun Yue
Li Fang
Publication date: 01-12-2008
Publisher: BioMed Central
Published in: Molecular Pain / Issue 1/2008
Electronic ISSN: 1744-8069
DOI: https://doi.org/10.1186/1744-8069-4-50

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effects of general anesthetics on visceral pain transmission in the spinal cord

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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