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Published in: Nutrition Journal 1/2011

Open Access 01-12-2011 | Research

Effects of Açai (Euterpe oleracea Mart.) berry preparation on metabolic parameters in a healthy overweight population: A pilot study

Authors: Jay K Udani, Betsy B Singh, Vijay J Singh, Marilyn L Barrett

Published in: Nutrition Journal | Issue 1/2011

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Abstract

Background

The purpose of this study was to evaluate the effect of açai fruit pulp on risk factors for metabolic disorders in overweight subjects. The açaí palm (Euterpe oleracea Mart.), which is native to South America, produces a small, black-purple fruit which is edible. The fruit has recently become popular as a functional food due to its antioxidant potential. Although several studies have been conducted in vitro and with animals, little is known about the potential health benefits in humans aside from an increase in plasma anti-oxidant capacity. Metabolic syndrome is a condition which is defined by a cluster of risk factors for cardiovascular disease and/or type-2 diabetes. Preliminary studies indicate that a reduction in reactive oxygen species can assist in the normalization of the metabolic pathways involved in this syndrome.

Methods

This was an open label pilot study conducted with 10 overweight adults (BMI ≥ 25 kg/m2 and ≤ 30 kg/m2) who took 100 g açai pulp twice daily for 1 month. The study endpoints included levels of fasting plasma glucose, insulin, cholesterol, triglycerides, exhaled (breath) nitric oxide metabolites (eNO) and plasma levels of high sensitivity C-reactive protein (hs-CRP). The response of blood glucose, blood pressure and eNO to a standardized meal was determined at baseline and following the 30 day treatment.

Results

Compared to baseline, there were reductions in fasting glucose and insulin levels following the 30 day treatment (both p < 0.02). There was also a reduction in total cholesterol (p = 0.03), as well as borderline significant reductions in LDL-cholesterol and the ratio of total cholesterol to HDL-cholesterol (both p = 0.051). Compared to baseline, treatment with açai ameliorated the post-prandial increase in plasma glucose following the standardized meal, measured as the area under the curve (p = 0.047). There was no effect on blood pressure, hs-CRP or eNO.

Conclusion

In this uncontrolled pilot study, consumption of açai fruit pulp reduced levels of selected markers of metabolic disease risk in overweight adults, indicating that further studies are warranted.
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Literature
1.
go back to reference Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al: Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009, 120: 1640-1645. 10.1161/CIRCULATIONAHA.109.192644.CrossRefPubMed Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al: Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009, 120: 1640-1645. 10.1161/CIRCULATIONAHA.109.192644.CrossRefPubMed
2.
go back to reference Grattagliano I, Palmieri VO, Portincasa P, Moschetta A, Palasciano G: Oxidative stress-induced risk factors associated with the metabolic syndrome: a unifying hypothesis. J Nutr Biochem. 2008, 19: 491-504. 10.1016/j.jnutbio.2007.06.011.CrossRefPubMed Grattagliano I, Palmieri VO, Portincasa P, Moschetta A, Palasciano G: Oxidative stress-induced risk factors associated with the metabolic syndrome: a unifying hypothesis. J Nutr Biochem. 2008, 19: 491-504. 10.1016/j.jnutbio.2007.06.011.CrossRefPubMed
3.
go back to reference Vincent HK, Taylor AG: Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans. Int J Obes. 2006, 30 (3): 400-418. 10.1038/sj.ijo.0803177.CrossRef Vincent HK, Taylor AG: Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans. Int J Obes. 2006, 30 (3): 400-418. 10.1038/sj.ijo.0803177.CrossRef
4.
go back to reference Roberts CK, Sindhu KK: Oxidative stress and metabolic syndrome. Life Sci. 2009, 84: 705-712. 10.1016/j.lfs.2009.02.026.CrossRefPubMed Roberts CK, Sindhu KK: Oxidative stress and metabolic syndrome. Life Sci. 2009, 84: 705-712. 10.1016/j.lfs.2009.02.026.CrossRefPubMed
5.
go back to reference Ando K, Fujita T: Metabolic syndrome and oxidative stress. Free Radic Biol Med. 2009, 47: 213-218. 10.1016/j.freeradbiomed.2009.04.030.CrossRefPubMed Ando K, Fujita T: Metabolic syndrome and oxidative stress. Free Radic Biol Med. 2009, 47: 213-218. 10.1016/j.freeradbiomed.2009.04.030.CrossRefPubMed
6.
go back to reference Cao G, Booth SL, Sadowski JA, Prior RL: Increases in human plasma antioxidant capacity after consumption of controlled diets high in fruit and vegetables. Am J Clin Nutr. 1998, 68: 1081-1087.PubMed Cao G, Booth SL, Sadowski JA, Prior RL: Increases in human plasma antioxidant capacity after consumption of controlled diets high in fruit and vegetables. Am J Clin Nutr. 1998, 68: 1081-1087.PubMed
7.
go back to reference Cao G, Russell RM, Lischner N, Prior RL: Serum antioxidant capacity is increased by consumption of strawberries, spinach, red wine or vitamin C in elderly women. J Nutr. 1998, 128: 2383-2390.PubMed Cao G, Russell RM, Lischner N, Prior RL: Serum antioxidant capacity is increased by consumption of strawberries, spinach, red wine or vitamin C in elderly women. J Nutr. 1998, 128: 2383-2390.PubMed
8.
go back to reference Fernandez-Panchon MS, Villano D, Troncoso AM, Garcia-Parrilla MC: Antioxidant activity of phenolic compounds: from in vitro results to in vivo evidence. Crit Rev Food Sci Nutr. 2008, 48: 649-671. 10.1080/10408390701761845.CrossRefPubMed Fernandez-Panchon MS, Villano D, Troncoso AM, Garcia-Parrilla MC: Antioxidant activity of phenolic compounds: from in vitro results to in vivo evidence. Crit Rev Food Sci Nutr. 2008, 48: 649-671. 10.1080/10408390701761845.CrossRefPubMed
9.
go back to reference Arts IC, Hollman PC: Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr. 2005, 81: 317S-325S.PubMed Arts IC, Hollman PC: Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr. 2005, 81: 317S-325S.PubMed
10.
go back to reference Dembinska-Kiec A, Mykkanen O, Kiec-Wilk B, Mykkanen H: Antioxidant phytochemicals against type 2 diabetes. Br J Nutr. 2008, 99 (E Suppl 1): ES109-ES117.PubMed Dembinska-Kiec A, Mykkanen O, Kiec-Wilk B, Mykkanen H: Antioxidant phytochemicals against type 2 diabetes. Br J Nutr. 2008, 99 (E Suppl 1): ES109-ES117.PubMed
11.
go back to reference Schauss AG, Wu X, Prior RL, Ou B, Patel D, Huang D, et al: Phytochemical and nutrient composition of the freeze-dried amazonian palm berry, Euterpe oleraceae mart. (acai). J Agric Food Chem. 2006, 54: 8598-8603. 10.1021/jf060976g.CrossRefPubMed Schauss AG, Wu X, Prior RL, Ou B, Patel D, Huang D, et al: Phytochemical and nutrient composition of the freeze-dried amazonian palm berry, Euterpe oleraceae mart. (acai). J Agric Food Chem. 2006, 54: 8598-8603. 10.1021/jf060976g.CrossRefPubMed
12.
go back to reference Del Pozo-Insfran D, Brenes CH, Talcott ST: Phytochemical composition and pigment stability of Acai (Euterpe oleracea Mart.). J Agric Food Chem. 2004, 52: 1539-1545. 10.1021/jf035189n.CrossRefPubMed Del Pozo-Insfran D, Brenes CH, Talcott ST: Phytochemical composition and pigment stability of Acai (Euterpe oleracea Mart.). J Agric Food Chem. 2004, 52: 1539-1545. 10.1021/jf035189n.CrossRefPubMed
13.
go back to reference Del Pozo-Insfran D, Percival SS, Talcott ST: Acai (Euterpe oleracea Mart.) polyphenolics in their glycoside and aglycone forms induce apoptosis of HL-60 leukemia cells. J Agric Food Chem. 2006, 54: 1222-1229. 10.1021/jf052132n.CrossRefPubMed Del Pozo-Insfran D, Percival SS, Talcott ST: Acai (Euterpe oleracea Mart.) polyphenolics in their glycoside and aglycone forms induce apoptosis of HL-60 leukemia cells. J Agric Food Chem. 2006, 54: 1222-1229. 10.1021/jf052132n.CrossRefPubMed
14.
go back to reference Lichtenthaler R, Rodrigues RB, Maia JG, Papagiannopoulos M, Fabricius H, Marx F: Total oxidant scavenging capacities of Euterpe oleracea Mart. (Acai) fruits. Int J Food Sci Nutr. 2005, 56: 53-64. 10.1080/09637480500082082.CrossRefPubMed Lichtenthaler R, Rodrigues RB, Maia JG, Papagiannopoulos M, Fabricius H, Marx F: Total oxidant scavenging capacities of Euterpe oleracea Mart. (Acai) fruits. Int J Food Sci Nutr. 2005, 56: 53-64. 10.1080/09637480500082082.CrossRefPubMed
15.
go back to reference Oliveira de SM, Silva M, Silva ME, de Paula OR, Pedrosa ML: Diet supplementation with acai (Euterpe oleracea Mart.) pulp improves biomarkers of oxidative stress and the serum lipid profile in rats. Nutrition. 2010, 26 (7-8): 804-810. 10.1016/j.nut.2009.09.007. Epub 2009 Dec 22CrossRef Oliveira de SM, Silva M, Silva ME, de Paula OR, Pedrosa ML: Diet supplementation with acai (Euterpe oleracea Mart.) pulp improves biomarkers of oxidative stress and the serum lipid profile in rats. Nutrition. 2010, 26 (7-8): 804-810. 10.1016/j.nut.2009.09.007. Epub 2009 Dec 22CrossRef
16.
go back to reference Mertens-Talcott SU, Rios J, Jilma-Stohlawetz P, Pacheco-Palencia LA, Meibohm B, Talcott ST, et al: Pharmacokinetics of anthocyanins and antioxidant effects after the consumption of anthocyanin-rich acai juice and pulp (Euterpe oleracea Mart.) in human healthy volunteers. J Agric Food Chem. 2008, 56: 7796-7802. 10.1021/jf8007037.CrossRefPubMed Mertens-Talcott SU, Rios J, Jilma-Stohlawetz P, Pacheco-Palencia LA, Meibohm B, Talcott ST, et al: Pharmacokinetics of anthocyanins and antioxidant effects after the consumption of anthocyanin-rich acai juice and pulp (Euterpe oleracea Mart.) in human healthy volunteers. J Agric Food Chem. 2008, 56: 7796-7802. 10.1021/jf8007037.CrossRefPubMed
17.
go back to reference Ou B, Hampsch-Woodill M, Prior RL: Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe. J Agric Food Chem. 2001, 49: 4619-4626. 10.1021/jf010586o.CrossRefPubMed Ou B, Hampsch-Woodill M, Prior RL: Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe. J Agric Food Chem. 2001, 49: 4619-4626. 10.1021/jf010586o.CrossRefPubMed
18.
go back to reference Malmstrom RE, Tornberg DC, Settergren G, Liska J, Angdin M, Lundberg JO, et al: Endogenous nitric oxide release by vasoactive drugs monitored in exhaled air. Am J Respir Crit Care Med. 2003, 168: 114-120. 10.1164/rccm.200302-159OC.CrossRefPubMed Malmstrom RE, Tornberg DC, Settergren G, Liska J, Angdin M, Lundberg JO, et al: Endogenous nitric oxide release by vasoactive drugs monitored in exhaled air. Am J Respir Crit Care Med. 2003, 168: 114-120. 10.1164/rccm.200302-159OC.CrossRefPubMed
20.
go back to reference Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, et al: Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001, 344: 1343-1350. 10.1056/NEJM200105033441801.CrossRefPubMed Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, et al: Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001, 344: 1343-1350. 10.1056/NEJM200105033441801.CrossRefPubMed
21.
go back to reference Simeonov SB, Botushanov NP, Karahanian EB, Pavlova MB, Husianitis HK, Troev DM: Effects of Aronia melanocarpa juice as part of the dietary regimen in patients with diabetes mellitus. Folia Med (Plovdiv). 2002, 44: 20-23. Simeonov SB, Botushanov NP, Karahanian EB, Pavlova MB, Husianitis HK, Troev DM: Effects of Aronia melanocarpa juice as part of the dietary regimen in patients with diabetes mellitus. Folia Med (Plovdiv). 2002, 44: 20-23.
22.
go back to reference Broncel M, Kozirog M, Duchnowicz P, Koter-Michalak M, Sikora J, Chojnowska-Jezierska J: Aronia melanocarpa extract reduces blood pressure, serum endothelin, lipid, and oxidative stress marker levels in patients with metabolic syndrome. Med Sci Monit. 2010, 16: CR28-CR34.PubMed Broncel M, Kozirog M, Duchnowicz P, Koter-Michalak M, Sikora J, Chojnowska-Jezierska J: Aronia melanocarpa extract reduces blood pressure, serum endothelin, lipid, and oxidative stress marker levels in patients with metabolic syndrome. Med Sci Monit. 2010, 16: CR28-CR34.PubMed
23.
go back to reference Ataie-Jafari A, Hosseini S, Karimi F, Pajouhi M: Effects of sour cherry juice on blood glucose and some cardiovascular risk factors improvements in diabetic women: A pilot study. Nutrition & Food Science. 2008, 38: 355-360. 10.1108/00346650810891414.CrossRef Ataie-Jafari A, Hosseini S, Karimi F, Pajouhi M: Effects of sour cherry juice on blood glucose and some cardiovascular risk factors improvements in diabetic women: A pilot study. Nutrition & Food Science. 2008, 38: 355-360. 10.1108/00346650810891414.CrossRef
24.
go back to reference Takikawa M, Inoue S, Horio F, Tsuda T: Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice. J Nutr. 2010, 140: 527-533. 10.3945/jn.109.118216.CrossRefPubMed Takikawa M, Inoue S, Horio F, Tsuda T: Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice. J Nutr. 2010, 140: 527-533. 10.3945/jn.109.118216.CrossRefPubMed
25.
go back to reference Nizamutdinova IT, Jin YC, Chung JI, Shin SC, Lee SJ, Seo HG, et al: The anti-diabetic effect of anthocyanins in streptozotocin-induced diabetic rats through glucose transporter 4 regulation and prevention of insulin resistance and pancreatic apoptosis. Mol Nutr Food Res. 2009, 53: 1419-1429. 10.1002/mnfr.200800526.CrossRefPubMed Nizamutdinova IT, Jin YC, Chung JI, Shin SC, Lee SJ, Seo HG, et al: The anti-diabetic effect of anthocyanins in streptozotocin-induced diabetic rats through glucose transporter 4 regulation and prevention of insulin resistance and pancreatic apoptosis. Mol Nutr Food Res. 2009, 53: 1419-1429. 10.1002/mnfr.200800526.CrossRefPubMed
26.
go back to reference Sasaki R, Nishimura N, Hoshino H, Isa Y, Kadowaki M, Ichi T, et al: Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice. Biochem Pharmacol. 2007, 74: 1619-1627. 10.1016/j.bcp.2007.08.008.CrossRefPubMed Sasaki R, Nishimura N, Hoshino H, Isa Y, Kadowaki M, Ichi T, et al: Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice. Biochem Pharmacol. 2007, 74: 1619-1627. 10.1016/j.bcp.2007.08.008.CrossRefPubMed
27.
go back to reference Rocha AP, Carvalho LC, Sousa MA, Madeira SV, Sousa PJ, Tano T, et al: Endothelium-dependent vasodilator effect of Euterpe oleracea Mart. (Acai) extracts in mesenteric vascular bed of the rat. Vascul Pharmacol. 2007, 46: 97-104. 10.1016/j.vph.2006.08.411.CrossRefPubMed Rocha AP, Carvalho LC, Sousa MA, Madeira SV, Sousa PJ, Tano T, et al: Endothelium-dependent vasodilator effect of Euterpe oleracea Mart. (Acai) extracts in mesenteric vascular bed of the rat. Vascul Pharmacol. 2007, 46: 97-104. 10.1016/j.vph.2006.08.411.CrossRefPubMed
28.
go back to reference Rosenkranz SK, Townsend DK, Steffens SE, Harms CA: Effects of a high-fat meal on pulmonary function in healthy subjects. Eur J Appl Physiol. 2010, 109 (3): 499-506. 10.1007/s00421-010-1390-1. Epub 2010 Feb 18CrossRefPubMed Rosenkranz SK, Townsend DK, Steffens SE, Harms CA: Effects of a high-fat meal on pulmonary function in healthy subjects. Eur J Appl Physiol. 2010, 109 (3): 499-506. 10.1007/s00421-010-1390-1. Epub 2010 Feb 18CrossRefPubMed
29.
go back to reference Ribeiro JC, Antunes LM, Aissa AF, Darin JD, De Rosso VV, Mercadante AZ, et al: Evaluation of the genotoxic and antigenotoxic effects after acute and subacute treatments with acai pulp (Euterpe oleracea Mart.) on mice using the erythrocytes micronucleus test and the comet assay. Mutat Res. 2010, 695 (1-2): 22-28. Epub 2009 Nov 3CrossRefPubMed Ribeiro JC, Antunes LM, Aissa AF, Darin JD, De Rosso VV, Mercadante AZ, et al: Evaluation of the genotoxic and antigenotoxic effects after acute and subacute treatments with acai pulp (Euterpe oleracea Mart.) on mice using the erythrocytes micronucleus test and the comet assay. Mutat Res. 2010, 695 (1-2): 22-28. Epub 2009 Nov 3CrossRefPubMed
Metadata
Title
Effects of Açai (Euterpe oleracea Mart.) berry preparation on metabolic parameters in a healthy overweight population: A pilot study
Authors
Jay K Udani
Betsy B Singh
Vijay J Singh
Marilyn L Barrett
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Nutrition Journal / Issue 1/2011
Electronic ISSN: 1475-2891
DOI
https://doi.org/10.1186/1475-2891-10-45

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