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Journal of Clinical Monitoring and Computing

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Open Access 03-02-2021 | Original Research

Effects of a single aerobic exercise on perfused boundary region and microvascular perfusion: a field study

Authors: Alexander Fuchs, Tobias Neumann, Hendrik Drinhaus, Anika Herrmann, Hans Vink, Thorsten Annecke

Published in: Journal of Clinical Monitoring and Computing | Issue 2/2022

Abstract

The endothelium and the glycocalyx play a pivotal role in regulating microvascular function and perfusion in health and critical illness. It is unknown today, whether aerobic exercise immediately affects dimensions of the endothelial surface layer (ESL) in relation to microvascular perfusion as a physiologic adaption to increased nutritional demands. This monocentric observational study was designed to determine real-time ESL and perfusion measurements of the sublingual microcirculation using sidestream dark field imaging performed in 14 healthy subjects before and after completing a 10 km trial running distance. A novel image acquisition and analysis software automatically analysed the perfused boundary region (PBR), an inverse parameter for red blood cell (RBC) penetration of the ESL, in vessels between 5 and 25 µm diameter. Microvascular perfusion was assessed by calculating RBC filling percentage. There was no significant immediate effect of exercise on PBR and RBC filling percentage. Linear regression analysis revealed a distinct association between change of PBR and change of RBC filling percentage (regression coefficient β: − 0.026; 95% confidence interval − 0.043 to − 0.009; p = 0.006). A single aerobic exercise did not induce a change of PBR or RBC filling percentage. The endothelium of the microvasculature facilitates efficient perfusion in vessels reacting with an increased endothelial surface layer.

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Title: Effects of a single aerobic exercise on perfused boundary region and microvascular perfusion: a field study
Authors: Alexander Fuchs
Tobias Neumann
Hendrik Drinhaus
Anika Herrmann
Hans Vink
Thorsten Annecke
Publication date: 03-02-2021
Publisher: Springer Netherlands
Published in: Journal of Clinical Monitoring and Computing / Issue 2/2022
Print ISSN: 1387-1307
Electronic ISSN: 1573-2614
DOI: https://doi.org/10.1007/s10877-021-00660-w

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Effects of a single aerobic exercise on perfused boundary region and microvascular perfusion: a field study

Abstract

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