01-07-2018 | Original Article
Effectiveness of inactivated quadrivalent influenza vaccine in the 2015/2016 season as assessed in both a test-negative case-control study design and a traditional case-control study design
Published in: European Journal of Pediatrics | Issue 7/2018
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What is Known:
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• Influenza vaccine effectiveness (VE) varies from year to year.
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• Observational studies are conventionally used for VE assessment. However, they are inherently susceptible to bias and confounding.
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What is New:
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• This is the first report of influenza VE assessment using more than one observational study and performed in a specific area during the same season.
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• VE estimates obtained in our traditional case-control study were lower than those in our test-negative case-control study, but both studies found significant VE against influenza.
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