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BMC Oral Health
Published in: BMC Oral Health 1/2021

01-12-2021 | Research article

Effectiveness of beta-tricalcium phosphate in comparison with other materials in treating periodontal infra-bony defects around natural teeth: a systematic review and meta-analysis

Authors: Reham AL Jasser, Abdulelah AlSubaie, Fayez AlShehri

Published in: BMC Oral Health | Issue 1/2021

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Abstract

Background

Beta-tricalcium phosphate in regenerative surgery has shown promising results in terms of bone gain and new vital bone formation; however, several studies have contradicted this finding. The aim of this study was to evaluate the effectiveness of beta-tricalcium phosphate compared to other grafting materials in the regeneration of periodontal infra-bony defects.

Methods

Electronic database (Cochrane, MEDLINE, PubMed, Embase, Science Citation Index Expanded) and manual searches for related data were performed up until March 2020. The outcomes were pocket depth reduction, clinical attachment level gain, and amount of bone fill.

Results

Five studies were selected based on the inclusion criteria. Bone regeneration with beta-tricalcium phosphate was observed to be superior to that with debridement alone but showed comparable results to other bone graft materials in terms of pocket depth reduction, clinical attachment level gain, and bone fill. Regenerative procedures for periodontal infra-bony defects that used beta-tricalcium phosphate in combination with other growth factors yielded superior outcomes. The meta-analysis revealed that for cases with two-wall defects, the use of beta-tricalcium phosphate yielded statistically significant differences in pocket depth reduction and clinical attachment level gain, but not in bone fill.

Conclusions

Beta-tricalcium phosphate appears to be a promising material for use in periodontal infra-bony defect regeneration around natural teeth. However, randomized clinical trials with larger sample sizes and more controlled study designs are needed to support these findings.
Literature
1.
Ana ID. Bone substituting materials in dental implantology. In: Budihardja A, Mücke T, editors. Bone management in dental implantology. New York: Springer; 2019.
2.
Driskell TD, Hassler CR, McCoy LR. The significance of resorbable bioceramics in the repair of bone defect. Proc Annu Conf Eng Med Biol. 1973;15:119.
3.
Ana ID, Satria GAP, Dewi AH, Ardhani R. Bioceramics for clinical application in regenerative dentistry. Adv Exp Med Biol. 2018;1077:309–16.CrossRefPubMed
4.
Heller AL, Koenigs JF, Brilliant JD, Melfi RC, Driskell TD. Direct pulp capping of permanent teeth in primates using a resorbable form of tricalcium phosphate ceramic. J Endod. 1975;1(3):95–101.CrossRefPubMed
5.
Mors WA, Kaminski EJ. Osteogenic replacement of tricalcium phosphate ceramic implants in the dog palate. Arch Oral Biol. 1975;20(5–6):365–7.CrossRefPubMed
6.
Ferraro JW. Experimental evaluation of ceramic calcium phosphate as a substitute for bone grafts. Plast Reconstr Surg. 1979;63(5):634–40.CrossRefPubMed
7.
Levin MP, Getter L, Cutright DE, Bhaskar SN. Biodegradable ceramic in periodontal defects. Oral Surg Oral Med Oral Pathol. 1974;38(3):344–51.CrossRefPubMed
8.
Cameron HU, Macnab I, Pilliar RM. Evaluation of a biodegradable ceramic. J Biomed Mater Res. 1977;11(2):179–86.CrossRefPubMed
9.
Saito H, Shiau HJ, Prasad H, Reynolds MA. Evaluation of a poly(lactic-co-glycolic) acid-coated β-tricalcium phosphate bone substitute for alveolar ridge preservation: case series. Clin Adv Periodontics. 2017;7:190–4.CrossRefPubMed
10.
Metsger DS, Driskell TD, Paulsrud JR. Tricalcium phosphate ceramic—a resorbable bone implant: review and current status. J Am Dent Assoc. 1982;105(6):1035–8.CrossRefPubMed
11.
Snyder AJ, Levin MP, Cutright DE. Alloplastic implants of tricalcium phosphate ceramic in human periodontal osseous defects. J Periodontol. 1984;55(5):273–7.CrossRefPubMed
12.
Bowers GM, Vargo JW, Levy B, Emerson JR, Bergquist JJ. Histologic observations following the placement of tricalcium phosphate implants in human intrabony defects. J Periodontol. 1986;57(5):286–7.CrossRefPubMed
13.
Kim S, Hu K-S, Jung U-W. Reosseointegration after regenerative surgical therapy using a synthetic bone substitute for peri-implantitis: human autopsy study. Int J Periodontics Restorative Dent. 2018;38(4):585–91.CrossRefPubMed
14.
Kishore DT, Bandiwadekar T, Padma R, Debunath S, Profulla A, Reddy A. Evaluation of relative efficacy of β-tricalcium phosphate with and without type 1 resorbable collagen membrane in periodontal infrabony defects: a clinical and radiographic study. J Contemp Dent Pract. 2013;14(2):193–201.CrossRefPubMed
15.
Saini N, Sikri P, Gupta H. Evaluation of the relative efficacy of autologous platelet-rich plasma in combination with β-tricalcium phosphate alloplast versus an alloplast alone in the treatment of human periodontal infrabony defects: a clinical and radiological study. Indian J Dent Res. 2011;22(1):107–15.CrossRefPubMed
16.
Kurkcu M, Benlidayi ME, Cam B, Sertdemir Y. Anorganic bovine-derived hydroxyapatite versus β-tricalcium phosphate in sinus augmentation. A comparative histomorphometric study. J Oral Implantol. 2012;2012:120522093526004.CrossRef
17.
Mardas N, D’Aiuto F, Mezzomo L, Arzoumanidi M, Donos N. Radiographic alveolar bone changes following ridge preservation with two different biomaterials. Clin Oral Implants Res. 2011;22(4):416–23.CrossRefPubMed
18.
Tosta M, Cortes ARG, Corrêa L, dos Pinto DS, Tumenas I, Katchburian E. Histologic and histomorphometric evaluation of a synthetic bone substitute for maxillary sinus grafting in humans. Clin Oral Implants Res. 2013;24(8):866–70.CrossRefPubMed
19.
Moher D, Liberati A, Tetzlaff J, Altman DG, Altman D, Antes G, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6:e1000097.PubMedPubMedCentral
20.
Cohen J. Weighted kappa: nominal scale agreement provision for scaled disagreement or partial credit. Psychol Bull. 1968;70(4):213–20.CrossRefPubMed
21.
Strub JR, Gaberthüel TW, Firestone AR. Comparison of tricalcium phosphate and frozen allogenic bone implants in man. J Periodontol. 1979;50(12):624–9.CrossRefPubMed
22.
Zafiropoulos G-GK, Hoffmann O, Kasaj A, Willershausen B, Weiss O, Van Dyke TE. Treatment of intrabony defects using guided tissue regeneration and autogenous spongiosa alone or combined with hydroxyapatite/β-tricalcium phosphate bone substitute or bovine-derived xenograft. J Periodontol. 2007;78(11):2216–25.CrossRefPubMed
23.
Rajesh JB, Nandakumar K, Varma HK, Komath M. Calcium phosphate cement as a “barrier-graft” for the treatment of human periodontal intraosseous defects. Indian J Dent Res. 2009;20(4):471–9.CrossRefPubMed
24.
Sukumar S, Drízhal I, Bukac J, Paulusová V, Pilathadka S. Surgical treatment of periodontal intrabony defects with calcium sulphate in combination with beta tricalcium phosphate—a 12-month retrospective clinical evaluation. Acta Medica (Hradec Kralove). 2010;53:229–34.CrossRef
25.
Cãlin C, Pãtrascu I. Growth factors and beta-tricalcium phosphate in the treatment of periodontal intraosseous defects: a systematic review and meta-analysis of randomised controlled trials. Arch Oral Biol. 2016;66:44–54.CrossRefPubMed
26.
Sculean A, Nikolidakis D, Nikou G, Ivanovic A, Chapple ILC, Stavropoulos A. Biomaterials for promoting periodontal regeneration in human intrabony defects: a systematic review. Periodontol. 2015;68(1):182–216.CrossRef
27.
Dewi AH, Ana ID. The use of hydroxyapatite bone substitute grafting for alveolar ridge preservation, sinus augmentation, and periodontal bone defect: a systematic review. Heliyon. 2018;4(10):e00884.CrossRefPubMedPubMedCentral
28.
Reynolds MA, Aichelmann-Reidy ME, Branch-Mays GL, Gunsolley JC. The efficacy of bone replacement grafts in the treatment of periodontal osseous defects. A systematic review. Ann Periodontol. 2003;8(1):227–65.CrossRefPubMed
Metadata
Title
Effectiveness of beta-tricalcium phosphate in comparison with other materials in treating periodontal infra-bony defects around natural teeth: a systematic review and meta-analysis
Authors
Reham AL Jasser
Abdulelah AlSubaie
Fayez AlShehri
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2021
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-021-01570-8

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