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Published in: Clinical Oral Investigations 3/2018

01-04-2018 | Original Article

Effectiveness and predictability of titanium-prepared platelet-rich fibrin for the management of multiple gingival recessions

Authors: Bilge Cansu Uzun, Esra Ercan, Mustafa Tunalı

Published in: Clinical Oral Investigations | Issue 3/2018

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Abstract

Objective

Titanium-prepared platelet-rich fibrin (T-PRF) is activated with titanium, which results in a more mature and aggregated form than PRF. In our previous studies, we established that the fibrin carpet formed with titanium had a firmer network structure, and longer resorption time in the tissue than the fibrin carpet formed with glass. The purpose of this randomized controlled clinical trial is to compare the effects of autogenous T-PRF and connective tissue graft (CTG).

Materials and methods

A total of 114 Miller Class I/II gingival recessions with abrasion defects were treated either T-PRF (63 teeth) or CTG (51 teeth) using a modified tunnel technique. Clinical periodontal indexes, keratinized tissue (KTW), gingival thickness, and recession depth were recorded before surgery and at 6- and 12-month follow-up examinations. The visual analog scale and healing index scores were assessed.

Results

The mean root coverages were 93.29 and 93.22% in the T-PRF and CTG groups, respectively, at 12 months post-operatively. CTG resulted in greater gingival thickness than T-PRF at 6 and 12 months post-surgery compared to baseline. Furthermore, the mean amounts of KTW increased by 1.97 and 0.75 mm in the T-PRF and CTG groups, respectively.

Conclusion

Within the limits of this study, the results demonstrated that T-PRF is safe and effective for treatment of multiple Miller Class I/II gingival recession defects.

Clinical relevance

T-PRF can serve as a good autogenous alternative to CTG, which is the gold standard for root coverage.
Literature
1.
go back to reference Marini MG, Greghi SL, Passanezi E et al (2004) Gingival recession: prevalence, extension and severity in adults. J Appl Oral Sci 12:250–255CrossRefPubMed Marini MG, Greghi SL, Passanezi E et al (2004) Gingival recession: prevalence, extension and severity in adults. J Appl Oral Sci 12:250–255CrossRefPubMed
2.
go back to reference Susin C, Haas AN, Oppermann RV et al (2004) Gingival recession: epidemiology and risk indicators in a representative urban Brazilian population. J Periodontol 75:1377–1386CrossRefPubMed Susin C, Haas AN, Oppermann RV et al (2004) Gingival recession: epidemiology and risk indicators in a representative urban Brazilian population. J Periodontol 75:1377–1386CrossRefPubMed
3.
go back to reference Sarfati A, Bourgeois D, Katsahian S et al (2010) Risk assessment for buccal gingival recession defects in an adult population. J Periodontol 81:1419–1425CrossRefPubMed Sarfati A, Bourgeois D, Katsahian S et al (2010) Risk assessment for buccal gingival recession defects in an adult population. J Periodontol 81:1419–1425CrossRefPubMed
4.
go back to reference Maroso FB, Gaio EJ, Rösing CK et al (2015) Correlation between gingival thickness and gingival recession in humans. Acta Odontol Latinoam 28(2):162–166PubMed Maroso FB, Gaio EJ, Rösing CK et al (2015) Correlation between gingival thickness and gingival recession in humans. Acta Odontol Latinoam 28(2):162–166PubMed
5.
go back to reference Roccuzzo M, Bunino M, Needleman I et al (2002) Periodontal plastic surgery for treatment of localized gingival recessions: a systematic review. J Clin Periodontol 29(Suppl 3):178–194CrossRefPubMed Roccuzzo M, Bunino M, Needleman I et al (2002) Periodontal plastic surgery for treatment of localized gingival recessions: a systematic review. J Clin Periodontol 29(Suppl 3):178–194CrossRefPubMed
6.
go back to reference Chambrone L, Chambrone D, Pustiglioni FE et al (2008) Can subepithelial connective tissue grafts be considered the gold standard procedure in the treatment of Miller Class I and II recession-type defects? J Dent 36:659–671CrossRefPubMed Chambrone L, Chambrone D, Pustiglioni FE et al (2008) Can subepithelial connective tissue grafts be considered the gold standard procedure in the treatment of Miller Class I and II recession-type defects? J Dent 36:659–671CrossRefPubMed
7.
go back to reference Wennstrom JL, Zucchelli G (1996) Increased gingival dimensions. A significant factor for successful outcome of root coverage procedures? A 2-year prospective clinical study. J Clin Periodontol 23:770–777CrossRefPubMed Wennstrom JL, Zucchelli G (1996) Increased gingival dimensions. A significant factor for successful outcome of root coverage procedures? A 2-year prospective clinical study. J Clin Periodontol 23:770–777CrossRefPubMed
8.
go back to reference Muller HP, Eger T, Schorb A (1998) Gingival dimensions after root coverage with free connective tissue grafts. J Clin Periodontol 25:424–430CrossRefPubMed Muller HP, Eger T, Schorb A (1998) Gingival dimensions after root coverage with free connective tissue grafts. J Clin Periodontol 25:424–430CrossRefPubMed
9.
go back to reference Rebele SF, Zuhr O, Schneider D et al (2014) Tunnel technique with connective tissue graft versus coronally advanced flap with enamel matrix derivative for root coverage: a RCT using 3D digital measuring methods. Part II. Volumetric studies on healing dynamics and gingival dimensions. J Clin Periodontol 41:593–603CrossRefPubMed Rebele SF, Zuhr O, Schneider D et al (2014) Tunnel technique with connective tissue graft versus coronally advanced flap with enamel matrix derivative for root coverage: a RCT using 3D digital measuring methods. Part II. Volumetric studies on healing dynamics and gingival dimensions. J Clin Periodontol 41:593–603CrossRefPubMed
10.
go back to reference Zucchelli G, Mounssif I, Mazzotti C et al (2014) Coronally advanced flap with and without connective tissue graft for the treatment of multiple gingival recessions: a comparative short- and long-term controlled randomized clinical trial. J Clin Periodontol 41:396–403CrossRefPubMed Zucchelli G, Mounssif I, Mazzotti C et al (2014) Coronally advanced flap with and without connective tissue graft for the treatment of multiple gingival recessions: a comparative short- and long-term controlled randomized clinical trial. J Clin Periodontol 41:396–403CrossRefPubMed
11.
go back to reference Harris RJ, Miller R, Miller LH et al (2005) Complications with surgical procedures utilizing connective tissue grafts: a follow-up of 500 consecutively treated cases. Int J Periodontics Restorative Dent 25(5):449–459PubMed Harris RJ, Miller R, Miller LH et al (2005) Complications with surgical procedures utilizing connective tissue grafts: a follow-up of 500 consecutively treated cases. Int J Periodontics Restorative Dent 25(5):449–459PubMed
12.
go back to reference Zucchelli G, Mele M, Stefanini M et al (2010) Patient morbidity and root coverage outcome after subepithelial connective tissue and de-epithelialized grafts: a comparative randomized-controlled clinical trial. J Clin Periodontol 37:728–738PubMed Zucchelli G, Mele M, Stefanini M et al (2010) Patient morbidity and root coverage outcome after subepithelial connective tissue and de-epithelialized grafts: a comparative randomized-controlled clinical trial. J Clin Periodontol 37:728–738PubMed
13.
go back to reference Zucchelli G, Mounssif I, Mazzotti C et al (2014) Does the dimension of the graft influence patient morbidity and root coverage outcomes? A randomized controlled clinical trial. J Clin Periodontol 41(7):708–716CrossRefPubMed Zucchelli G, Mounssif I, Mazzotti C et al (2014) Does the dimension of the graft influence patient morbidity and root coverage outcomes? A randomized controlled clinical trial. J Clin Periodontol 41(7):708–716CrossRefPubMed
14.
go back to reference Tatakis DN, Chambrone L, Allen EP et al (2015) Periodontal soft tissue root coverage procedures: a consensus report from the AAP Regeneration Workshop. J Periodontol 86(2 Suppl):52–55CrossRef Tatakis DN, Chambrone L, Allen EP et al (2015) Periodontal soft tissue root coverage procedures: a consensus report from the AAP Regeneration Workshop. J Periodontol 86(2 Suppl):52–55CrossRef
15.
go back to reference Petrungaro PS (2001) Using platelet-rich plasma to accelerate soft tissue maturation in esthetic periodontal surgery. Compend Contin Educ Dent 22(9):729–732PubMed Petrungaro PS (2001) Using platelet-rich plasma to accelerate soft tissue maturation in esthetic periodontal surgery. Compend Contin Educ Dent 22(9):729–732PubMed
16.
go back to reference Choukroun J, Adda F, Schoeffler C, Vervelle A (2001) Une opportunité en paro-implantologie: le PRF. Implantodontie 42:55–62 Choukroun J, Adda F, Schoeffler C, Vervelle A (2001) Une opportunité en paro-implantologie: le PRF. Implantodontie 42:55–62
17.
go back to reference Dohan Ehrenfest DM, Rasmusson L, Albrektsson T (2009) Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol 27:158–167CrossRefPubMed Dohan Ehrenfest DM, Rasmusson L, Albrektsson T (2009) Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol 27:158–167CrossRefPubMed
18.
go back to reference Aroca S, Keglevich T, Barbieri B et al (2009) Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study. J Periodontol 80:244–252CrossRefPubMed Aroca S, Keglevich T, Barbieri B et al (2009) Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study. J Periodontol 80:244–252CrossRefPubMed
19.
go back to reference Del Corso M, Sammartino G, Dohan Ehrenfest DM (2009) Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study. J Periodontol 80(11):1694–1697 author reply 1697-9CrossRefPubMed Del Corso M, Sammartino G, Dohan Ehrenfest DM (2009) Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study. J Periodontol 80(11):1694–1697 author reply 1697-9CrossRefPubMed
20.
go back to reference Jankovic S, Aleksic Z, Milinkovic I et al (2010) The coronally advanced flap in combination with platelet-rich fibrin (PRF) and enamel matrix derivative in the treatment of gingival recession: a comparative study. Eur J Esthet Dent 5(3):260–273PubMed Jankovic S, Aleksic Z, Milinkovic I et al (2010) The coronally advanced flap in combination with platelet-rich fibrin (PRF) and enamel matrix derivative in the treatment of gingival recession: a comparative study. Eur J Esthet Dent 5(3):260–273PubMed
21.
go back to reference Jankovic S, Aleksic Z, Klokkevold P et al (2012) Use of platelet-rich fibrin membrane following treatment of gingival recession: a randomized clinical trial. Int J Periodontics Restorative Dent 32(2):41–50 Jankovic S, Aleksic Z, Klokkevold P et al (2012) Use of platelet-rich fibrin membrane following treatment of gingival recession: a randomized clinical trial. Int J Periodontics Restorative Dent 32(2):41–50
22.
go back to reference Eren G, Atilla G (2014) Platelet-rich fibrin in the treatment of localized gingival recessions: a split-mouth randomized clinical trial. Clin Oral Investig 18(8):1941–1948CrossRefPubMed Eren G, Atilla G (2014) Platelet-rich fibrin in the treatment of localized gingival recessions: a split-mouth randomized clinical trial. Clin Oral Investig 18(8):1941–1948CrossRefPubMed
23.
go back to reference Gupta S, Banthia R, Singh P et al (2015) Clinical evaluation and comparison of the efficacy of coronally advanced flap alone and in combination with platelet rich fibrin membrane in the treatment of Miller Class I and II gingival recessions. Contemp Clin Dent 6(2):153–160CrossRefPubMedPubMedCentral Gupta S, Banthia R, Singh P et al (2015) Clinical evaluation and comparison of the efficacy of coronally advanced flap alone and in combination with platelet rich fibrin membrane in the treatment of Miller Class I and II gingival recessions. Contemp Clin Dent 6(2):153–160CrossRefPubMedPubMedCentral
24.
go back to reference Keceli HG, Kamak G, Erdemir EO et al (2015) The adjunctive effect of platelet-rich fibrin to connective tissue graft in the treatment of buccal recession defects: results of a randomized, parallel-group controlled trial. J Periodontol 86(11):1221–1230CrossRefPubMed Keceli HG, Kamak G, Erdemir EO et al (2015) The adjunctive effect of platelet-rich fibrin to connective tissue graft in the treatment of buccal recession defects: results of a randomized, parallel-group controlled trial. J Periodontol 86(11):1221–1230CrossRefPubMed
25.
go back to reference Tunalı M, Özdemir H, Arabacı T et al (2015) Clinical evaluation of autologous platelet-rich fibrin (L-PRF) in the treatment of multiple adjacent gingival recession defects: a 12-month study. Int J Periodontics Restorative Dent 35(1):105–114CrossRef Tunalı M, Özdemir H, Arabacı T et al (2015) Clinical evaluation of autologous platelet-rich fibrin (L-PRF) in the treatment of multiple adjacent gingival recession defects: a 12-month study. Int J Periodontics Restorative Dent 35(1):105–114CrossRef
26.
go back to reference Uraz A, Sezgin Y, Yalim M et al (2015) Comparative evaluation of platelet-rich fibrin membrane and connective tissue graft in the treatment of multiple adjacent recession defects: a clinical study. Journal of Dental Sciences 10(1):36–45CrossRef Uraz A, Sezgin Y, Yalim M et al (2015) Comparative evaluation of platelet-rich fibrin membrane and connective tissue graft in the treatment of multiple adjacent recession defects: a clinical study. Journal of Dental Sciences 10(1):36–45CrossRef
27.
go back to reference Castro AB, Meschi N, Temmerman A et al (2017) Regenerative potential of leucocyte- and platelet-rich fibrin. Part A: intra-bony defects, furcation defects and periodontal plastic surgery. A systematic review and meta-analysis. J Clin Periodontol 44(1):67–82CrossRefPubMed Castro AB, Meschi N, Temmerman A et al (2017) Regenerative potential of leucocyte- and platelet-rich fibrin. Part A: intra-bony defects, furcation defects and periodontal plastic surgery. A systematic review and meta-analysis. J Clin Periodontol 44(1):67–82CrossRefPubMed
28.
go back to reference Öncü E, Bayram B, Kantarci A et al (2016) Positive effect of platelet rich fibrin on osseointegration. Med Oral Patol Oral Cir Bucal. Sep 1 21(5):e601–e607PubMedPubMedCentral Öncü E, Bayram B, Kantarci A et al (2016) Positive effect of platelet rich fibrin on osseointegration. Med Oral Patol Oral Cir Bucal. Sep 1 21(5):e601–e607PubMedPubMedCentral
29.
go back to reference Choukroun J, Diss A, Simonpieri A et al (2006) Plateletrich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:56–60CrossRef Choukroun J, Diss A, Simonpieri A et al (2006) Plateletrich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:56–60CrossRef
30.
go back to reference O’Connell SM (2007) Safety issues associated with platelet-rich fibrin method. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:587(author reply):587–593CrossRef O’Connell SM (2007) Safety issues associated with platelet-rich fibrin method. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:587(author reply):587–593CrossRef
31.
go back to reference Tunali M, Ozdemir H, Kucukodacı Z et al (2013) In vivo evaluation of titanium-prepared plateletrich fibrin (T-PRF): a new platelet concentrate. Br J Oral Maxillofac Surg 51:438–443CrossRefPubMed Tunali M, Ozdemir H, Kucukodacı Z et al (2013) In vivo evaluation of titanium-prepared plateletrich fibrin (T-PRF): a new platelet concentrate. Br J Oral Maxillofac Surg 51:438–443CrossRefPubMed
32.
go back to reference Tunali M, Ozdemir H, Kucukodacı Z, et al. (2014) A novel platelet concentrate: titanium-prepared platelet-rich fibrin. BioMed Research International Article ID 209548 Tunali M, Ozdemir H, Kucukodacı Z, et al. (2014) A novel platelet concentrate: titanium-prepared platelet-rich fibrin. BioMed Research International Article ID 209548
33.
go back to reference Tunali M, Ozdemir H, Kucukodacı Z et al (2015) A novel platelet concentrate for guided bone regeneration: Titanium Prepared Platelet-Rich Fibrin (T-PRF). Gulhane Med J 57:102–106CrossRef Tunali M, Ozdemir H, Kucukodacı Z et al (2015) A novel platelet concentrate for guided bone regeneration: Titanium Prepared Platelet-Rich Fibrin (T-PRF). Gulhane Med J 57:102–106CrossRef
34.
go back to reference Loe H, Silness J (1963) Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 21:533–551CrossRefPubMed Loe H, Silness J (1963) Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 21:533–551CrossRefPubMed
35.
go back to reference Silness J, Loe H (1964) Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condtion. Acta Odontol Scand 22:121–135CrossRefPubMed Silness J, Loe H (1964) Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condtion. Acta Odontol Scand 22:121–135CrossRefPubMed
36.
go back to reference Huang LH, Neiva RE, Wang HL (2005) Factors affecting the outcomes of coronally advanced flap root coverage procedure. J Periodontol 76:1729–1734CrossRefPubMed Huang LH, Neiva RE, Wang HL (2005) Factors affecting the outcomes of coronally advanced flap root coverage procedure. J Periodontol 76:1729–1734CrossRefPubMed
37.
go back to reference Kassab MM, Cohen RE, Andreana S et al (2006) The effect of EDTA in attachment gain and root coverage. Compend Contin Educ Dent 27(6):353–360PubMed Kassab MM, Cohen RE, Andreana S et al (2006) The effect of EDTA in attachment gain and root coverage. Compend Contin Educ Dent 27(6):353–360PubMed
38.
go back to reference Cortellini P, Tonetti MS (2001) Microsurgical approach to periodontal regeneration. Initial evaluation in a case cohort. J Periodontol 72:559–569CrossRefPubMed Cortellini P, Tonetti MS (2001) Microsurgical approach to periodontal regeneration. Initial evaluation in a case cohort. J Periodontol 72:559–569CrossRefPubMed
39.
go back to reference Miron RJ, Zucchelli G, Pikos MA et al (2017) Use of platelet-rich fibrin in regenerative dentistry: a systematic review. Clin Oral Invest 21(6):1913–1927CrossRef Miron RJ, Zucchelli G, Pikos MA et al (2017) Use of platelet-rich fibrin in regenerative dentistry: a systematic review. Clin Oral Invest 21(6):1913–1927CrossRef
40.
go back to reference Moraschini V, Barboza Edos S (2016) Use of platelet-rich fibrin membrane in the treatment of gingival recession: a systematic review and meta-analysis. J Periodontol 87:281–290CrossRefPubMed Moraschini V, Barboza Edos S (2016) Use of platelet-rich fibrin membrane in the treatment of gingival recession: a systematic review and meta-analysis. J Periodontol 87:281–290CrossRefPubMed
41.
go back to reference Ustaoglu G, Ercan E, Tunali M (2016) The role of titanium-prepared platelet-rich fibrin in palatal mucosal wound healing and histoconduction. Acta Odontol Scand 74(7):558–564CrossRefPubMed Ustaoglu G, Ercan E, Tunali M (2016) The role of titanium-prepared platelet-rich fibrin in palatal mucosal wound healing and histoconduction. Acta Odontol Scand 74(7):558–564CrossRefPubMed
42.
go back to reference Öncü E (2017) The use of platelet-rich fibrin versus subepithelial connective tissue graft in treatment of multiple gingival recessions: a randomized clinical trail. Int J Periodontics Restorative Dent 37(2):1–9CrossRef Öncü E (2017) The use of platelet-rich fibrin versus subepithelial connective tissue graft in treatment of multiple gingival recessions: a randomized clinical trail. Int J Periodontics Restorative Dent 37(2):1–9CrossRef
43.
go back to reference Eren G, Kantarcı A, Sculean A et al (2016) Vascularization after treatment of gingival recession defects with platelet-rich fibrin or connective tissue graft. Clin Oral Invest 20(8):2045–2053CrossRef Eren G, Kantarcı A, Sculean A et al (2016) Vascularization after treatment of gingival recession defects with platelet-rich fibrin or connective tissue graft. Clin Oral Invest 20(8):2045–2053CrossRef
Metadata
Title
Effectiveness and predictability of titanium-prepared platelet-rich fibrin for the management of multiple gingival recessions
Authors
Bilge Cansu Uzun
Esra Ercan
Mustafa Tunalı
Publication date
01-04-2018
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 3/2018
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-017-2211-2

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