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European Radiology
Published in: European Radiology 1/2011

01-01-2011 | Contrast Media

Effect on renal function of an iso-osmolar contrast agent in patients with monoclonal gammopathies

Authors: Lorenzo Preda, Alberto Agazzi, Sara Raimondi, Carla Federica Lanfranchi, Rita Passerini, Albania Calvetta, Giovanni Martinelli, Massimo Bellomi

Published in: European Radiology | Issue 1/2011

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Abstract

Objective

To assess the safety of the non-ionic iso-osmolar contrast agent iodixanol on renal function in patients with monoclonal gammopathies undergoing CT.

Methods

We explored the effect of iodixanol on renal function in 30 patients with monoclonal gammopathies and 20 oncological patients with a normal electrophoretic profile (control group). The parameters used to estimate renal function were: serum creatinine, eGFR (determined 24 h before and 48 h after the administration of iodixanol), and urinary excretion of Neutrophil Gelatinase-Associated Lipocalin (NGAL) determined 2 h and 24 h after. Serum creatinine was also determined 1 month after the administration of iodixanol.

Results

No significant increase in serum creatinine values were observed in the monoclonal gammopathies group and in 19/20 patients in the control group. Only 1 patient in the control group developed a transient contrast agent-induced nephropathy. We found no statistically significant difference between the two groups regarding the percentage variation from baseline values of serum creatinine, creatinine clearance, NGAL 2 h after, and eGFR. Whereas NGAL at 24 h showed a statistically significant increase in patients with Monoclonal gammopathies.

Conclusion

The use of iodixanol appears to be safe in patients with monoclonal gammopathies and an eGFR ≥ 60 ml/min/1.73 mq.
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Metadata
Title
Effect on renal function of an iso-osmolar contrast agent in patients with monoclonal gammopathies
Authors
Lorenzo Preda
Alberto Agazzi
Sara Raimondi
Carla Federica Lanfranchi
Rita Passerini
Albania Calvetta
Giovanni Martinelli
Massimo Bellomi
Publication date
01-01-2011
Publisher
Springer-Verlag
Published in
European Radiology / Issue 1/2011
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-010-1908-2

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