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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-05-2011 | Original Article

Effect of the positron range of ¹⁸F, ⁶⁸Ga and ¹²⁴I on PET/CT in lung-equivalent materials

Authors: Gerrit J. Kemerink, Mariëlle G. W. Visser, Renee Franssen, Emiel Beijer, Mariangela Zamburlini, Servé G. E. A. Halders, Boudewijn Brans, Felix M. Mottaghy, Gerrit J. J. Teule

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 5/2011

Abstract

Purpose

The aim of this study was to investigate the effect of positron range on visualization and quantification in ¹⁸F, ⁶⁸Ga and ¹²⁴I positron emission tomography (PET)/CT of lung-like tissue.

Methods

Different sources were measured in air, in lung-equivalent foams and in water, using a clinical PET/CT and a microPET system. Intensity profiles and curves with the cumulative number of annihilations were derived and numerically characterized.

Results

⁶⁸Ga and ¹²⁴I gave similar results. Their intensity profiles in lung-like foam had a peak similar to that for ¹⁸F, and tails of very low intensity, but extending over distances of centimetres and containing a large fraction of all annihilations. For 90% recovery, volumes of interest with diameters up to 50 mm were required, and recovery within the 10% intensity isocontour was as low as 30%. In contrast, tailing was minor for ¹⁸F.

Conclusion

Lung lesions containing ¹⁸F, ⁶⁸Ga or ¹²⁴I will be visualized similarly, and at least as sharp as in soft tissue. Nevertheless, for quantification of ⁶⁸Ga and ¹²⁴I large volumes of interest are needed for complete activity recovery. For clinical studies containing noise and background, new quantification approaches may have to be developed.

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Title: Effect of the positron range of 18F, 68Ga and 124I on PET/CT in lung-equivalent materials
Authors: Gerrit J. Kemerink
Mariëlle G. W. Visser
Renee Franssen
Emiel Beijer
Mariangela Zamburlini
Servé G. E. A. Halders
Boudewijn Brans
Felix M. Mottaghy
Gerrit J. J. Teule
Publication date: 01-05-2011
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 5/2011
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-011-1732-1

At a glance: The STEP trials

Springer Medicine

Effect of the positron range of ¹⁸F, ⁶⁸Ga and ¹²⁴I on PET/CT in lung-equivalent materials

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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