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Critical Care
Published in: Critical Care 1/2010

01-03-2010 | Poster presentation

Effect of restoration of 25OHD3 status in prolonged critical illness on serum innate immunity parameters LL-37 and sCD163

Authors: CM Ingels, SJ Van Cromphaut, PJ Wouters, HJ Moller, E Van Herck, I Jans, R Bouillon, G Van den Berghe

Published in: Critical Care | Special Issue 1/2010

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Excerpt

We previously observed that critically ill patients are vitD deficient. This status cannot be restored by increasing the normally recommended intravenous vitD dose. The antimicrobial peptide LL-37 is expressed in macrophages upon stimulation by 25OHD3. sCD163 is a soluble pattern-recognition receptor, which is a marker of macrophage activation and a predictor of mortality in SIRS. The aim of this study is to unravel the impact of 25OHD3 deficiency and normalization on innate immunity parameters - CRP, LL-37 and sCD163 - in critical illness. …
Metadata
Title
Effect of restoration of 25OHD3 status in prolonged critical illness on serum innate immunity parameters LL-37 and sCD163
Authors
CM Ingels
SJ Van Cromphaut
PJ Wouters
HJ Moller
E Van Herck
I Jans
R Bouillon
G Van den Berghe
Publication date
01-03-2010
Publisher
BioMed Central
Published in
Critical Care / Issue Special Issue 1/2010
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc8822

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