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01-07-2020 | Original Paper

Effect of propylene glycol on the skin penetration of drugs

Authors: Victor Carrer, Cristina Alonso, Mercè Pont, Miriam Zanuy, Mònica Córdoba, Sonia Espinosa, Clara Barba, Marc A. Oliver, Meritxell Martí, Luisa Coderch

Published in: Archives of Dermatological Research | Issue 5/2020

Abstract

Propylene glycol (PG) has been used in formulations as a co-solvent and/or to enhance drug permeation through the skin from topical preparations. Two skin in vitro permeation approaches are used to determine the effect of PG on drug penetration. The in vitro Skin-PAMPA was performed using 24 actives applied in aqueous buffer or PG. PG modulates permeability by increasing or diminishing it in the compounds with poor or high permeability, respectively. Percutaneous absorption using pigskin on Franz diffusion cells was performed on seven actives and their commercial formulations. The commercial formulations evaluated tend to have a lower permeability than their corresponding PG solutions but maintain the compound distribution in the different strata: stratum corneum, epidermis and dermis. The results indicate the enhancer properties of PG for all compounds, especially for the hydrophilic ones. Additionally, the Synchrotron-Based Fourier Transform Infrared microspectroscopy technique is applied to study the penetration of PG and the molecular changes that the vehicle may promote in the different skin layers. Results showed an increase of the areas under the curve indicating the higher amount of lipids in the deeper layers and altering the lipidic order of the bilayer structure to a more disordered lipid structure.

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Title: Effect of propylene glycol on the skin penetration of drugs
Authors: Victor Carrer
Cristina Alonso
Mercè Pont
Miriam Zanuy
Mònica Córdoba
Sonia Espinosa
Clara Barba
Marc A. Oliver
Meritxell Martí
Luisa Coderch
Publication date: 01-07-2020
Publisher: Springer Berlin Heidelberg
Published in: Archives of Dermatological Research / Issue 5/2020
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-019-02017-5

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Effect of propylene glycol on the skin penetration of drugs

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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