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Aesthetic Plastic Surgery

Published in:

01-10-2012 | Original Article

Effect of Preoperative Subcutaneous Platelet-Rich Plasma and Fibrin Glue Application on Skin Flap Survival

Authors: Fulya Findikcioglu, Kemal Findikcioglu, Reha Yavuzer, Nese Lortlar, Kenan Atabay

Published in: Aesthetic Plastic Surgery | Issue 5/2012

Abstract

Background

The aim of this study was to compare the effects of preoperative subcutaneous platelet-rich plasma and fibrin glue administration on skin flap survival.

Methods

One week before surgery; saline, platelet-rich plasma, fibrin glue, and thrombin solutions were applied under rat skin flap areas in Groups I, II, III, and IV, respectively. Unipedicled epigastric flaps were elevated in the first three groups but could not be elevated in Group IV because of preoperative abdominal skin necrosis. Necrotic area measurements, microangiography, and histological and immunohistochemical evaluations were performed.

Results

Platelet-rich plasma reduced the percentage of necrotic area when compared to other groups. Histologically and microangiographically an increased number of arterioles were observed in the platelet-rich plasma group. Thrombin (when used alone) caused abdominal skin necrosis. Increased expression of VEGF and PDGF was found in all platelet-rich plasma-treated flaps. There was no significant difference between groups with respect to TGF-β3 staining intensity.

Conclusion

In this study preoperative administration of platelet-rich plasma mimicked the pharmacological delay effect and enhanced flap survival. Individual use of thrombin was found to be unsuitable in flap surgery.

Level of Evidence I

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Title: Effect of Preoperative Subcutaneous Platelet-Rich Plasma and Fibrin Glue Application on Skin Flap Survival
Authors: Fulya Findikcioglu
Kemal Findikcioglu
Reha Yavuzer
Nese Lortlar
Kenan Atabay
Publication date: 01-10-2012
Publisher: Springer-Verlag
Published in: Aesthetic Plastic Surgery / Issue 5/2012
Print ISSN: 0364-216X
Electronic ISSN: 1432-5241
DOI: https://doi.org/10.1007/s00266-012-9954-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effect of Preoperative Subcutaneous Platelet-Rich Plasma and Fibrin Glue Application on Skin Flap Survival

Abstract

Background

Methods

Results

Conclusion

Level of Evidence I

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Level of Evidence I

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