Top

World Journal of Surgery

Published in:

01-06-2009

Effect of Preoperative Hyperfibrinogenemia on Recurrence of Colorectal Cancer Without a Systemic Inflammatory Response

Authors: Hiroharu Yamashita, Joji Kitayama, Masataka Taguri, Hirokazu Nagawa

Published in: World Journal of Surgery | Issue 6/2009

Abstract

Background

Disorders in the blood coagulation system are often associated with malignancy. Patients with colorectal cancer (CRC) have been shown to have abnormal data for various coagulation tests.

Methods

We retrospectively analyzed the relation between the preoperative plasma fibrinogen level and tumor recurrence in 569 patients with CRC who underwent curative surgical resection and were followed up without adjuvant chemotherapy.

Results

The plasma fibrinogen level showed a positive association with tumor recurrence, age, sex, T stage, and TNM classification. When divided with the median value, hyperfibrinogenemia is positively correlated with tumor recurrence, although it lost independence in the multivariate analysis. In the C-reactive protein (CRP)-negative population, hyperfibrinogenemia is independently correlated with tumor recurrence and recurrence-free survival. In contrast, hyperfibrinogenemia has no effect on recurrence in CRP-positive patients.

Conclusions

Hyperfibrinogenemia is clinically relevant in tumor recurrence before a systemic inflammatory response and thus can be a useful predictor of recurrence in the preinflammatory stage of CRC.

Sakamoto J, Ohashi Y, Hamada C et al (2004) Efficacy of oral adjuvant therapy after resection of colorectal cancer: 5-year results from three randomized trials. J Clin Oncol 22:484–492PubMed

Laurie JA, Moertel CG, Fleming TR et al (1989) Surgical adjuvant therapy of large-bowel carcinoma: an evaluation of levamisole and the combination of levamisole and fluorouracil: the North Central Cancer Treatment Group and the Mayo Clinic. J Clin Oncol 7:1447–1456PubMed

Akasu T, Moriya Y, Ohashi Y et al (2006) Adjuvant chemotherapy with uracil-tegafur for pathological stage III rectal cancer after mesorectal excision with selective lateral pelvic lymphadenectomy: a multicenter randomized controlled trial. Jpn J Clin Oncol 36:237–244PubMedCrossRef

Moertel CG, Fleming TR, Macdonald JS et al (1995) Fluorouracil plus levamisole as effective adjuvant therapy after resection of stage III colon carcinoma: a final report. Ann Intern Med 122:321–326PubMed

Chu DZ, Erickson CA, Russell MP et al (1991) Prognostic significance of carcinoembryonic antigen in colorectal carcinoma: serum levels before and after resection and before recurrence. Arch Surg 126:314–316PubMed

Wolmark N, Fisher B, Wieand HS et al (1984) The prognostic significance of preoperative carcinoembryonic antigen levels in colorectal cancer: results from NSABP (National Surgical Adjuvant Breast and Bowel Project) clinical trials. Ann Surg 199:375–382PubMedCrossRef

Wang WS, Lin JK, Chiou TJ et al (2000) Preoperative carcinoembryonic antigen level as an independent prognostic factor in colorectal cancer: Taiwan experience. Jpn J Clin Oncol 30:12–16PubMedCrossRef

Louhimo J, Carpelan-Holmstrom M, Alfthan H et al (2002) Serum HCG beta, CA 72-4 and CEA are independent prognostic factors in colorectal cancer. Int J Cancer 101:545–548PubMedCrossRef

Harrison LE, Guillem JG, Paty P et al (1997) Preoperative carcinoembryonic antigen predicts outcomes in node-negative colon cancer patients: a multivariate analysis of 572 patients. J Am Coll Surg 185:55–59PubMed

10.

Wanebo HJ, Rao B, Pinsky CM et al (1978) Preoperative carcinoembryonic antigen level as a prognostic indicator in colorectal cancer. N Engl J Med 299:448–451PubMed

11.

Takahashi T, Kato T, Kodaira S et al (1996) Prognostic factors of colorectal cancer: results of multivariate analysis of curative resection cases with or without adjuvant chemotherapy. Am J Clin Oncol 19:408–415PubMedCrossRef

12.

Yamashita H, Kitayama J, Nagawa H (2005) Hyperfibrinogenemia is a useful predictor for lymphatic metastasis in human gastric cancer. Jpn J Clin Oncol 35:595–600PubMedCrossRef

13.

Yamashita H, Kitayama J, Kanno N et al (2006) Hyperfibrinogenemia is associated with lymphatic as well as hematogenous metastasis and worse clinical outcome in T2 gastric cancer. BMC Cancer 6:147PubMedCrossRef

14.

Chen Z, Malhotra PS, Thomas GR et al (1999) Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer. Clin Cancer Res 5:1369–1379PubMed

15.

Palumbo JS, Kombrinck KW, Drew AF et al (2000) Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells. Blood 96:3302–3309PubMed

16.

Palumbo JS, Potter JM, Kaplan LS et al (2002) Spontaneous hematogenous and lymphatic metastasis, but not primary tumor growth or angiogenesis, is diminished in fibrinogen-deficient mice. Cancer Res 62:6966–6972PubMed

17.

Costantini V, Zacharski LR, Moritz TE et al (1990) The platelet count in carcinoma of the lung and colon. Thromb Haemost 64:501–505PubMed

18.

Oya M, Akiyama Y, Okuyama T et al (2001) High preoperative plasma D-dimer level is associated with advanced tumor stage and short survival after curative resection in patients with colorectal cancer. Jpn J Clin Oncol 31:388–394PubMedCrossRef

19.

Abbasciano V, Bianchi MP, Trevisani L et al (1995) Platelet activation and fibrinolysis in large bowel cancer. Oncology 52:381–384PubMedCrossRef

20.

Iversen LH, Thorlacius-Ussing O (2002) Relationship of coagulation test abnormalities to tumour burden and postoperative DVT in resected colorectal cancer. Thromb Haemost 87:402–408PubMed

21.

Blackwell K, Hurwitz H, Lieberman G et al (2004) Circulating D-dimer levels are better predictors of overall survival and disease progression than carcinoembryonic antigen levels in patients with metastatic colorectal carcinoma. Cancer 101:77–82PubMedCrossRef

22.

Wang Q, Xie R, Zhang QY (2005) Clinical significance of plasma fibrinogen level in patients with colorectal cancer. Zhonghua Zhong Liu Za Zhi 27:544–546PubMed

23.

Nozoe T, Matsumata T, Kitamura M et al (1998) Significance of preoperative elevation of serum C-reactive protein as an indicator for prognosis in colorectal cancer. Am J Surg 176:335–338PubMedCrossRef

24.

Shimada H, Kitabayashi H, Nabeya Y et al (2003) Treatment response and prognosis of patients after recurrence of esophageal cancer. Surgery 133:24–31PubMedCrossRef

25.

Nakanishi H, Araki N, Kudawara I et al (2002) Clinical implications of serum C-reactive protein levels in malignant fibrous histiocytoma. Int J Cancer 99:167–170PubMedCrossRef

26.

Stamatiadis AP, St. Toumanidou M, Vyssoulis GP et al (1990) Value of serum acute-phase reactant proteins and carcinoembryonic antigen in the preoperative staging of colorectal cancer: a multivariate analysis. Cancer 65:2055–2057PubMedCrossRef

27.

Chung YC, Chang YF (2003) Serum C-reactive protein correlates with survival in colorectal cancer patients but is not an independent prognostic indicator. Eur J Gastroenterol Hepatol 15:369–373PubMedCrossRef

28.

McMillan DC, Canna K, McArdle CS (2003) Systemic inflammatory response predicts survival following curative resection of colorectal cancer. Br J Surg 90:215–219PubMedCrossRef

29.

Black S, Kushner I, Samols D (2004) C-reactive protein. J Biol Chem 279:48487–48490PubMedCrossRef

30.

Poynter JN, Gruber SB, Higgins PD et al (2005) Statins and the risk of colorectal cancer. N Engl J Med 352:2184–2192PubMedCrossRef

31.

Kleemann R, Gervois PP, Verschuren L et al (2003) Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation. Blood 101:545–551PubMedCrossRef

32.

Palumbo JS, Talmage KE, Massari JV et al (2005) Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells. Blood 105:178–185PubMedCrossRef

33.

Yano H, Kitayama J, Hatano K et al (2001) Clustered cancer cells show a distinct adhesion behavior from single cell form under physiological shear conditions. J Exp Clin Cancer Res 20:407–412

34.

Nieswandt B, Hafner M, Echtenacher B et al (1999) Lysis of tumor cells by natural killer cells in mice is impeded by platelets. Cancer Res 59:1295–1300PubMed

35.

Gale AJ, Gordon SG (2001) Update on tumor cell procoagulant factors. Acta Haematol 106:25–32PubMedCrossRef

Title: Effect of Preoperative Hyperfibrinogenemia on Recurrence of Colorectal Cancer Without a Systemic Inflammatory Response
Authors: Hiroharu Yamashita
Joji Kitayama
Masataka Taguri
Hirokazu Nagawa
Publication date: 01-06-2009
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 6/2009
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-009-9992-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effect of Preoperative Hyperfibrinogenemia on Recurrence of Colorectal Cancer Without a Systemic Inflammatory Response

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 6/2009

Treatment of the Open Abdomen with the Commercially Available Vacuum-Assisted Closure System in Patients with Abdominal Sepsis

The Increasing Use of Liver Transplantation Surgical Techniques in the Management of Renal and Nonrenal Cancer With or Without Inferior Vena Cava Tumor Thrombus

Prevalence of Helicobacter pylori Seropositivity Among Patients Undergoing Bariatric Surgery: A Preliminary Study

Investigation of the Lymphatic Stream of the Stomach in Gastric Cancer with Solitary Lymph Node Metastasis

Intraabdominal Hypertension and the Abdominal Compartment Syndrome in Burn Patients

Oncologic Outcomes of Self-Expanding Metallic Stent Insertion as a Bridge to Surgery in the Management of Left-Sided Colon Cancer Obstruction: Comparison with Nonobstructing Elective Surgery