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BMC Medical Genetics

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Open Access 01-12-2016 | Research article

Effect of Pregnane X Receptor^*1B genetic polymorphisms on postoperative analgesia with fentanyl in Chinese patients undergoing gynecological surgery

Authors: Jing-Jing Yuan, Xiao-Jing Ma, Zhi-Song Li, Yan-Zi Chang, Wei Zhang, Quan-Cheng Kan, Jun-Kai Hou, Li-Rong Zhang

Published in: BMC Medical Genetics | Issue 1/2016

Abstract

Background

The purpose of the study was to investigate the effects of the pregnane X receptor (PXR)*1B polymorphisms on CYP3A4 enzyme activity and postoperative fentanyl consumption in Chinese patients undergoing gynecological surgery.

Methods

A total of 287 females of Han ethnicity, aged 20 to 50 years old, ASA I or II, scheduled to abdominal total hysterectomy or myomectomy under general anesthesia were enrolled. The analgesic model used was fentanyl consumption via patient-controlled intravenous analgesia (PCIA) in the post-operative period. Additionally, pain was assessed using a visual analog score (VAS). Pain scores, occurrence of adverse reactions and consumption of fentanyl were recorded during the 24 h postoperative period. The enzyme activity of CYP3A4 was evaluated by measuring the plasma ratio of 1′-hydroxymidazolam to midazolam 1 h after intravenous administration of 0.1 mg/kg midazolam. PXR genotyping was performed by direct DNA sequencing and the PXR ^* 1B haplotype was analyzed via PHASE V.2.1 software.

Results

The polymorphism frequency of PXR11156A > C/11193 T > C and 8055C > T were 49.6 and 49.3%, and the rate of PXR ^* 1B haplotype was 48.8% in our study. None of the pain scores, consumption of fentanyl 24 h post-operatively or enzyme activity of CYP3A4, showed differences among different genotypes.

Conclusions

PXR11156A > C, PXR11193T > C, PXR8055C > T or the PXR ^* 1B haplotype do not appear to be important factors contributing to CYP3A4 activity and interindividual variations in postoperative fentanyl consumption in Han female patients undergoing gynecological surgery.

Trial registration

The DNA samples were obtained since 2007 to 2010 year in our hospital, there was no registration at that time. So this section is not applicable to our research.

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Title: Effect of Pregnane X Receptor*1B genetic polymorphisms on postoperative analgesia with fentanyl in Chinese patients undergoing gynecological surgery
Authors: Jing-Jing Yuan
Xiao-Jing Ma
Zhi-Song Li
Yan-Zi Chang
Wei Zhang
Quan-Cheng Kan
Jun-Kai Hou
Li-Rong Zhang
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: BMC Medical Genetics / Issue 1/2016
Electronic ISSN: 1471-2350
DOI: https://doi.org/10.1186/s12881-016-0348-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effect of Pregnane X Receptor^*1B genetic polymorphisms on postoperative analgesia with fentanyl in Chinese patients undergoing gynecological surgery

Abstract

Background

Methods

Results

Conclusions

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Trial registration

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