Top

European Radiology

Published in:

01-10-2016 | Interventional

Effect of perioperative parecoxib sodium on postoperative pain control for transcatheter arterial chemoembolization for inoperable hepatocellular carcinoma: a prospective randomized trial

Authors: Ning Lv, Yanan Kong, Luwen Mu, Tao Pan, Qiankun Xie, Ming Zhao

Published in: European Radiology | Issue 10/2016

Abstract

Objectives

Pain is one of the most common side effects of transcatheter arterial chemoembolization (TACE) treatment. This study aimed to assess the analgesic effect of parecoxib sodium for postoperative pain control in patients with inoperable hepatocellular carcinoma (HCC) undergoing TACE.

Materials and methods

This randomized placebo-controlled prospective clinical study was conducted at a single cancer centre. Patients were randomly assigned to receive parecoxib sodium (experimental group; n = 60) or 0.9 % sodium chloride (control group; n = 60) 1 h before TACE and once every 12 h for 2 days after TACE. Pain level, morphine consumption, adverse events, and quality of life were evaluated and compared between the two groups.

Results

Pain scores, percentage distribution of pain categories, and morphine consumption were significantly lower in the experimental group than in the control group (P < 0.05). Fever score comparisons revealed significantly better body temperature balance in the experimental group than in the control group (P = 0.024). Quality-of-life scores in the experimental group were significantly better than those in the control group (P < 0.05).

Conclusions

Our results demonstrate that the perioperative administration of parecoxib significantly improved its effectiveness in the control of postoperative pain after TACE.

Key Points

• Perioperative administration of parecoxib is effective for control of pain after TACE.

• COX-2 inhibitors provide effective and safe pain control.

• Parecoxib helps improve quality-of-life after TACE for patients with inoperable hepatocellular carcinoma.

Ikeda K, Kobayashi M, Kawamura Y et al (2011) Stage progression of small hepatocellular carcinoma after radical therapy: comparisons of radiofrequency ablation and surgery using the Markov model. Liver Int 5:692–699CrossRef

Ikeda K, Kawamura Y, Kobayashi M et al (2014) Prevention of disease progression with anti-inflammatory therapy in patients with HCV-related cirrhosis: a Markov model. Oncology 5–6:295–302CrossRef

Yamada R, Sato M, Kawabata M, Nakatsuka H, Nakamura K, Takashima S (1983) Hepatic artery embolization in 120 patients with unresectable hepatoma. Radiology 2:397–401CrossRef

Llovet JM, Real MI, Montana X et al (2002) Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial. Lancet 9319:1734–1739CrossRef

Camma C, Schepis F, Orlando A et al (2002) Transarterial chemoembolization for unresectable hepatocellular carcinoma: meta-analysis of randomized controlled trials. Radiology 1:47–54CrossRef

Takayasu K, Arii S, Ikai I et al (2006) Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients. Gastroenterology 2:461–469CrossRef

Ikeda M, Arai Y, Park SJ et al (2013) Prospective study of transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma: an Asian cooperative study between Japan and Korea. J Vasc Interv Radiol 4:490–500CrossRef

Bruix J, Sherman M (2011) Management of hepatocellular carcinoma: an update. Hepatology 3:1020–1022CrossRef

Arii S, Sata M, Sakamoto M et al (2010) Management of hepatocellular carcinoma: report of consensus meeting in the 45th annual meeting of the japan society of hepatology (2009). Hepatol Res 7:667–685CrossRef

10.

Marelli L, Stigliano R, Triantos C et al (2007) Transarterial therapy for hepatocellular carcinoma: which technique is more effective? A systematic review of cohort and randomized studies. Cardiovasc Intervent Radiol 1:6–25CrossRef

11.

Zhou B, Wang J, Yan Z, Shi P, Kan Z (2012) Liver cancer: effects, safety, and cost-effectiveness of controlled-release oxycodone for pain control after TACE. Radiology 3:1014–1021CrossRef

12.

Momeni M, Crucitti M, De Kock M (2006) Patient-controlled analgesia in the management of postoperative pain. Drugs 18:2321–2337CrossRef

13.

Zochling J, van der Heijde D, Burgos-Vargas R et al (2006) ASAS/EULAR recommendations for the management of ankylosing spondylitis. Ann Rheum Dis 4:442–452CrossRef

14.

Jirarattanaphochai K, Thienthong S, Sriraj W et al (2008) Effect of parecoxib on postoperative pain after lumbar spine surgery: a bicenter, randomized, double-blinded, placebo-controlled trial. Spine (Phila Pa 1976) 2:132–139CrossRef

15.

Hubbard RC, Naumann TM, Traylor L, Dhadda S (2003) Parecoxib sodium has opioid-sparing effects in patients undergoing total knee arthroplasty under spinal anaesthesia. Br J Anaesth 2:166–172CrossRef

16.

Duseja A (2015) Staging of hepatocellular carcinoma. J Clin Exp Hepatol Suppl 3:S74–79

17.

National Cancer Institute (2009) Common Terminology Criteria for dverse Events (CTCAE) Version 4.0. v403: June 14, 2010

18.

Okusaka T, Kasugai H, Shioyama Y et al (2009) Transarterial chemotherapy alone versus transarterial chemoembolization for hepatocellular carcinoma: a randomized phase III trial. J Hepatol 6:1030–1036CrossRef

19.

Peng ZW, Zhang YJ, Chen MS et al (2013) Radiofrequency ablation with or without transcatheter arterial chemoembolization in the treatment of hepatocellular carcinoma: a prospective randomized trial. J Clin Oncol 4:426–432CrossRef

20.

Lee SH, Hahn ST, Park SH (2001) Intraarterial lidocaine administration for relief of pain resulting from transarterial chemoembolization of hepatocellular carcinoma: its effectiveness and optimal timing of administration. Cardiovasc Intervent Radiol 6:368–371CrossRef

21.

Fiorentini G, Aliberti C, Benea G et al (2008) TACE of liver metastases from colorectal cancer adopting irinotecan-eluting beads: beneficial effect of palliative intra-arterial lidocaine and post-procedure supportive therapy on the control of side effects. Hepatogastroenterology 88:2077–2082

22.

Cepeda MS, Tzortzopoulou A, Thackrey M, Hudcova J, Arora Gandhi P, Schumann R (2010) Adjusting the pH of lidocaine for reducing pain on injection. Cochrane Database Syst Rev 12, CD006581PubMed

23.

Zhu Y, Wang S, Wu H, Wu Y (2014) Effect of perioperative parecoxib on postoperative pain and local inflammation factors PGE2 and IL-6 for total knee arthroplasty: a randomized, double-blind, placebo-controlled study. Eur J Orthop Surg Traumatol 3:395–401CrossRef

24.

Malan TP Jr, Marsh G, Hakki SI, Grossman E, Traylor L, Hubbard RC (2003) Parecoxib sodium, a parenteral cyclooxygenase 2 selective inhibitor, improves morphine analgesia and is opioid-sparing following total hip arthroplasty. Anesthesiology 4:950–956CrossRef

25.

Malan TP Jr, Gordon S, Hubbard R, Snabes M (2005) The cyclooxygenase-2-specific inhibitor parecoxib sodium is as effective as 12 mg of morphine administered intramuscularly for treating pain after gynecologic laparotomy surgery. Anesth Analg 2:454–460CrossRef

26.

Buvanendran A, Kroin JS, Tuman KJ et al (2003) Effects of perioperative administration of a selective cyclooxygenase 2 inhibitor on pain management and recovery of function after knee replacement: a randomized controlled trial. JAMA 18:2411–2418CrossRef

27.

Gan TJ, Joshi GP, Viscusi E et al (2004) Preoperative parenteral parecoxib and follow-up oral valdecoxib reduce length of stay and improve quality of patient recovery after laparoscopic cholecystectomy surgery. Anesth Analg 6:1665–1673, table of contents CrossRef

28.

Crile GW (1913) The kinetic theory of shock and its prevention through anociassociation. Lancet 2:7–16CrossRef

29.

Woolf CJ, Wall PD (1986) Morphine-sensitive and morphine-insensitive actions of C-fibre input on the rat spinal cord. Neurosci Lett 2:221–225CrossRef

30.

Brennan TJ, Umali EF, Zahn PK (1997) Comparison of pre- versus post-incision administration of intrathecal bupivacaine and intrathecal morphine in a rat model of postoperative pain. Anesthesiology 6:1517–1528CrossRef

31.

Hayakawa K, Tanikake M, Kirishima T et al (2014) The incidence of contrast-induced nephropathy (CIN) following transarterial chemoembolisation (TACE) in patients with hepatocellular carcinoma (HCC). Eur Radiol 5:1105–1111CrossRef

32.

Vogl TJ, Zangos S, Balzer JO et al (2007) Transarterial chemoembolization (TACE) in hepatocellular carcinoma: technique, indication and results. Röfo 11:1113–1126

Title: Effect of perioperative parecoxib sodium on postoperative pain control for transcatheter arterial chemoembolization for inoperable hepatocellular carcinoma: a prospective randomized trial
Authors: Ning Lv
Yanan Kong
Luwen Mu
Tao Pan
Qiankun Xie
Ming Zhao
Publication date: 01-10-2016
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 10/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4207-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Effect of perioperative parecoxib sodium on postoperative pain control for transcatheter arterial chemoembolization for inoperable hepatocellular carcinoma: a prospective randomized trial

Abstract

Objectives

Materials and methods

Results

Conclusions

Key Points

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusions

Key Points

Please log in to get access to this content

Other articles of this Issue 10/2016

Diffusion measurement of intraplaque hemorrhage and intramural hematoma using diffusion weighted MRI at 3T in cervical artery

Survival benefit of chemoembolization plus Iodine125 seed implantation in unresectable hepatitis B-related hepatocellular carcinoma with PVTT: a retrospective matched cohort study

Head and neck reconstructive surgery: what the radiologist needs to know

Erratum to: Performance of ultralow-dose CT with iterative reconstruction in lung cancer screening: limiting radiation exposure to the equivalent of conventional chest X-ray imaging

Radiological and clinical predictors of long-term outcome in rotator cuff calcific tendinitis

Additional diagnostic value of shear-wave elastography and color Doppler US for evaluation of breast non-mass lesions detected at B-mode US