Top

Published in:

01-12-2006 | Original Article

Effect of meloxicam on gingival crevicular fluid IL-1beta and IL1 receptor antagonist levels in subjects with chronic periodontitis, and its effects on clinical parameters

Authors: Hulya Toker, Ismail Marakoglu, Omer Poyraz

Published in: Clinical Oral Investigations | Issue 4/2006

Abstract

The aim of the present study was to determine the effects of meloxicam after initial periodontal treatment on interleukin-1beta (IL-1β) and IL-1 receptor antagonist (IL-1ra) in gingival crevicular fluid (GCF) and clinical parameters in the chronic periodontitis patients. Data were obtained from 30 patients with chronic periodontitis. Fifteen chronic periodontitis patients received 7.5 mg meloxicam, and 15 patients received placebo tablets in a 1×1 regimen for 1 month. All subjects were nonsmokers and had not received any periodontal therapy. The plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment level (CAL) were recorded. The GCF was collected using a paper strip: eluted and enzyme-linked immunoabsorbent assays (ELISAs) were performed to determine the cytokine levels. The clinical data and GCF samples were obtained after periodontal therapy and 1 month after periodontal therapy. The PI, GI, PD, and GCF IL-1ra decreased significantly (p<0.05) in meloxicam group at first month when comparing the initial levels. While decrease of the PI was statistically significant in control group (p<0.05), statistically significant changes were not determined in the other clinical parameters and GCF cytokine levels (p>0.05). There were no significant differences between two groups in any of the investigated parameters. Our observations did not reveal any influence of meloxicam on levels of IL-1β and IL-1ra in chronic periodontitis. Additional clinical studies are advisable to determine whether COX-2 selective drugs alter periodontal disease outcome with greater safety.

Alexander DCC, Martin JC, King PJ, Powell JR, Caves J, Cohen ME (1996) Interleukin-1 beta, prostaglandin E₂ and immunoglobulin G subclasses in gingival crevicular fluid in patients undergoing periodontal therapy. J Periodontol 67:755–762PubMed

Bezerra MM, de Lima V, Alencar VBM et al (2000) Selective cyclooxygenase-2 inhibition prevents alveolar bone loss in experimental periodontitis in rats. J Periodontol 71:1009–1014PubMedCrossRef

Boström L, Linder LE, Bergstrom J (2000) Smoking and GCF levels of IL-1β and IL-1ra in periodontal disease. J Clin Periodontol 27:250–255PubMedCrossRef

Dinarello CA, Wolff SM (1993) The role of interleukin-1 in disease. New Engl J Med 14:106–113CrossRef

Figueredo CMS, Riberio MSM, Fischer RG, Gustafsson A (1999) Increased interleukin-1β concentration in gingival crevicular fluid as a characteristic of periodontitis. J Periodontol 70:1457–1463PubMedCrossRef

Gamanol J, Acevedo A, Bascones A, Jorge O, Silva A (2000) Levels of Interleukin-1β, -8, -10 and RANTES in gingival crevicular fluid and cell populations in adult periodontitis patients and the effect of periodontal treatment. J Periodontol 71:1535–1545CrossRef

Giannopoulou C, Cappuyns I, Mombelli A (2003) Effect of smoking on gingival crevicular fluid cytokine profile during experimental gingivitis. J Clin Periodontol 30:996–1002PubMedCrossRef

Giannopoulou C, Kama JJ, Mombelli A (2003) Effect of inflammation, smoking, and stress on gingival, crevicular fluid cytokine level. J Clin Periodontol 30:145–153PubMedCrossRef

Gonzales JR, Herrmann JM, Boedeker RH, Francz PI, Biesalski H, Meyle J (2001) Concentration of interleukin-1β and neutrophil elastase activity in gingival crevicular fluid during experimental gingivitis. J Clin Periodontol 28:544–549PubMedCrossRef

10.

Heath JK, Saklatvala J, Meikle MC, Atkinson SJ, Reynolds JJ (1985) Pig interleukin-1 (catabolin) is a potent stimulator of bone resorption. Calcif Tissue Int 37:95–97PubMed

11.

Howell TH (1993) Blocking peridontal disease progression with anti-inflammatory agents. J Periodontol 64:828–833PubMed

12.

Howell TH, Jeffcoat MK, Goldhaber P, Reddy MS, Kaplan ML, Johnson HG (1991) Inhibition of alveolar bone loss in beagles with the NSAID naproxen. J Periodontal Res 26:498–501PubMedCrossRef

13.

Ishihara Y, Kuroyagani T, Shirozi N et al (1997) Gingival crevicular interleukin-1 and interleukin-1 receptor antagonist levels in periodontally healthy and diseased sites. J Periodontal Res 32:524–529PubMedCrossRef

14.

Jeffcoat MK, Reddy MS, Haigh S, Buchanan W, Doyle MJ, Meredith MP (1995) A comparison of topical ketorolac, systemic flurbiprofen, and placebo for the inhibition of bone loss in adult periodontitis. J Periodontol 66:329–338PubMed

15.

Jeffcoat MK, Williams RC, Reddy MS, English R, Goldhaber P (1988) Flurbiprofen treatment of human periodontitis: effect on alveolar bone height and metabolism. J Periodontal Res 23:381–385PubMedCrossRef

16.

Kabashima H, Nagata K, Hasguchi I, Toriya Y, Iijima T, Maki K, Maeda K (1996) Interleukin-1 receptor antagonist and interleukin-4 in gingival crevicular fluid of patients with inflammatory periodontal disease. J Oral Pathol Med 25:449–455PubMedCrossRef

17.

Löe H (1967) The gingival index, the plaque index and the retention index systems. J Periodontol 38:610–616PubMed

18.

Penglis PS, James MJ, Cleland LG (2001) Cyclooxygenase inhibitors: any reservations? Review. Intern Med J 31:37–41PubMedCrossRef

19.

Rainsford KD (1994) Non-steroidal anti-inflammatory drugs. In: Dale MM, Foreman JC, Fan T-PD (eds) Textbook of immunopharmacology. Blackwell, Oxford, pp 309–319

20.

Rawlinson A, Dalati MHN, Rahman S, Walsh TF, Fairlough AL (2000) Interleukin-1 and IL-1 receptor antagonist in gingival crevicular fluid. J Clin Periodontol 27:738–743PubMedCrossRef

21.

Reddy MS, Palcanis KG, Barnett ML, Haigh S, Charles CH, Jeffcoat MK (1993) Efficacy of meclofenamate sodium (Meclomen) in the treatment of rapidly progressive periodontitis. J Clin Periodontol 20:635–640PubMedCrossRef

22.

Tatakis DN (1993) Interleukin-1 and bone metabolism: a review. J Periodontol 64:416–431PubMed

23.

William RC, Offenbacher S, Jefcoat MK, Howell TH, Johnson HG, Hall CM (1988) Indomethacin or flurbiprofen treatment of periodontitis in beagles: Effect on crevicular fluid arachidonic acid metabolites compared with effect on alveolar bone loss. J Periodontal Res 23:134–138CrossRef

24.

Williams RC, Jeffcoat MK, Wechter WJ, Johnson HG, Kaplan ML, Goldhaber P (1984) Non-steroidal anti-inflammatory drug treatment of periodontitis in beagles. J Periodontal Res 19:633–637PubMedCrossRef

25.

Yoshinari N, Kawase H, Mitani A et al (2004) Effects of scaling and root planning on the amounts of interleukin-1 and interleukin-1 receptor antagonist and the mRNA expression of interleukin-1β in gingival crevicular fluid and gingival tissues. J Periodontal Res 39:158–167PubMedCrossRef

Title: Effect of meloxicam on gingival crevicular fluid IL-1beta and IL1 receptor antagonist levels in subjects with chronic periodontitis, and its effects on clinical parameters
Authors: Hulya Toker
Ismail Marakoglu
Omer Poyraz
Publication date: 01-12-2006
Publisher: Springer-Verlag
Published in: Clinical Oral Investigations / Issue 4/2006
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-006-0062-3

At a glance: The STEP trials

Springer Medicine

Effect of meloxicam on gingival crevicular fluid IL-1beta and IL1 receptor antagonist levels in subjects with chronic periodontitis, and its effects on clinical parameters

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 4/2006

Influence of the methodology and evaluation criteria on determining microleakage in dentin–restorative interfaces

Clinical features of incontinentia pigmenti with emphasis on oral and dental abnormalities

Calendar of Events

Buffering effect of a prophylactic gel on dental plaque

In vitro cleaning efficacy and resistance to insertion test of interdental brushes

How may stressful experiences contribute to the development of temporomandibular disorders?