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01-08-2014 | Short communication

Effect of magnesium oxide on interfraction prostate motion and rectal filling in prostate cancer radiotherapy

Analysis of a randomized clinical trial

Authors: Annemarie M. den Harder, B.Sc., Carla H. van Gils, Ph.D., Alexis N.T.J. Kotte, Ph.D., Marco van Vulpen, M.D., Ph.D., Irene M. Lips, M.D., Ph.D.

Published in: Strahlentherapie und Onkologie | Issue 8/2014

Abstract

Purpose

To investigate whether magnesium oxide reduces the interfraction motion of the prostate and the amount of rectal filling and rectal gas, which influences prostate position during radiotherapy for prostate cancer.

Patients and methods

From December 2008 to February 2010, 92 prostate cancer patients scheduled for intensity-modulated radiotherapy (77 Gy in 35 fractions) using fiducial marker-based position verification were randomly assigned to receive magnesium oxide (500 mg twice a day) or placebo during radiotherapy. In a previous study, we investigated the effect on intrafraction motion and did not find a difference between the treatment arms. Here, we compared the interfraction prostate motion between the two treatment arms as well as the amount of rectal filling and rectal air pockets using pretreatment planning computed tomography and magnetic resonance imagingscans.

Results

There was no statistically significant difference between the treatment arms in translation and rotation of the prostate between treatment fractions, except for the rotation around the cranial caudal axis. However, the difference was less than 1° and therefore considered not clinically relevant. There was no significant difference in the amount of rectal filling and rectal air pockets between the treatment arms.

Conclusion

Magnesium oxide is not effective in reducing the interfraction prostate motion or the amount of rectal filling and rectal gas during external-beam radiotherapy. Therefore, magnesium oxide is not recommended in clinical practice for these purposes.

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Title: Effect of magnesium oxide on interfraction prostate motion and rectal filling in prostate cancer radiotherapy
Analysis of a randomized clinical trial
Authors: Annemarie M. den Harder, B.Sc.
Carla H. van Gils, Ph.D.
Alexis N.T.J. Kotte, Ph.D.
Marco van Vulpen, M.D., Ph.D.
Irene M. Lips, M.D., Ph.D.
Publication date: 01-08-2014
Publisher: Springer Berlin Heidelberg
Published in: Strahlentherapie und Onkologie / Issue 8/2014
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-014-0660-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effect of magnesium oxide on interfraction prostate motion and rectal filling in prostate cancer radiotherapy

Analysis of a randomized clinical trial

Abstract

Purpose

Patients and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Patients and methods

Results

Conclusion

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