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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2015

Open Access 01-12-2015 | Research article

Effect of lycopene against gastroesophageal reflux disease in experimental animals

Authors: Arvind Kumar Giri, Jitendra Kumar Rawat, Manjari Singh, Swetlana Gautam, Gaurav Kaithwas

Published in: BMC Complementary Medicine and Therapies | Issue 1/2015

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Abstract

Background

Lycopene is a robust antioxidant with significant antiulcer activity. Henceforth, the present study was ventured to elucidate the effect of lycopene on experimental esophagitis.

Methods

Groups of rats were subjected to forestomach and pylorus ligation with subsequent treatment with lycopene (50 and 100 mg/kg, po) and pantoprazole (30 mg/kg, po).

Results

Treatment with lycopene evidenced sententious physiological protection when scrutinized for pH, acidity (total and free), volume of gastric juices and esophagitis index. Lycopene further embarked diminishing effect on oxidative stress through synchronising lipid and protein peroxidation along with regulating the enzymatic activity of SOD and catalase. Lycopene also modified the levels of immunoregulatory cytokines (IL- 1β and IL-6) favourably. The dose dependent efficacy of lycopene in the current experimental condition was also attested when exemplified morphologically through scanning electron microscopy.

Conclusion

From the current line of evidences, it was concluded that lycopene can impart momentous protection against experimental esophagitis by wrapping up the reactive oxygen species and through dual inhibition of the arachidonic acid pathway.
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Metadata
Title
Effect of lycopene against gastroesophageal reflux disease in experimental animals
Authors
Arvind Kumar Giri
Jitendra Kumar Rawat
Manjari Singh
Swetlana Gautam
Gaurav Kaithwas
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2015
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-015-0631-6

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