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Open Access 01-07-2018 | Psychiatry and Preclinical Psychiatric Studies - Short communication

Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala

Authors: Artur Pałasz, Marcelina Pałka, Łukasz Filipczyk, Itiana Castro Menezes, Ewa Rojczyk, John J. Worthington, Aneta Piwowarczyk-Nowak, Marek Krzystanek, Ryszard Wiaderkiewicz

Published in: Journal of Neural Transmission | Issue 7/2018

Abstract

Neuroleptics modulate the expression level of some regulatory neuropeptides in the brain. However, if these therapeutics influence the peptidergic circuits in the amygdala remains unclear. This study specifies the impact profile of the classical antipsychotic drugs on mRNA expression of the spexin/NPQ, kisspeptin-1 and POMC in the rat amygdala. Animals were treated with haloperidol and chlorpromazine for 28 days prior to transcript quantification via qPCR. Haloperidol and chlorpromazine induced a change in the expression of all neuropeptides analyzed. Both drugs led to the decrease of Kiss-1 expression, whereas in POMC and spexin/NPQ their up-regulation in the amygdala was detected. These modulating effects on may represent alternative, so far unknown mechanisms, of classical antipsychotic drugs triggering pharmacological responses.

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Title: Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala
Authors: Artur Pałasz
Marcelina Pałka
Łukasz Filipczyk
Itiana Castro Menezes
Ewa Rojczyk
John J. Worthington
Aneta Piwowarczyk-Nowak
Marek Krzystanek
Ryszard Wiaderkiewicz
Publication date: 01-07-2018
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 7/2018
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-018-1868-2

At a glance: The STEP trials

Springer Medicine

Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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