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01-12-2012 | Original Article

Effect of Crataegus extract on carbon tetrachloride-induced hepatic damage

Authors: Omar M. E. Abdel Salam, Amany A. Sleem, Nermeen Shafee

Published in: Comparative Clinical Pathology | Issue 6/2012

Abstract

The current study evaluated the effect of a standardized Crataegus extract on liver injury induced by acute carbon tetrachloride (CCl₄) administration in rats. Crataegus extract (10, 20 or 40 mg/kg), silymarin (25 mg/kg) or saline (control) was given once daily orally simultaneously with CCl₄ and for 1 week thereafter. Crataegus extract given at the above doses reduced serum alanine aminotransferase (ALT) levels by 28.8, 31.8 and 36.4%, respectively, when compared to the CCl₄ control group. Serum aspartate aminotransferase (AST) levels decreased by 14.3, 15.5 and 20.6%, respectively, while alkaline phosphatase (ALP) decreased by 21.8% by the extract at 40 mg/kg. The administration of silymarin reduced ALT, AST and ALP levels by 66.8, 64.9 and 60%, respectively. In CCl₄-treated rats, the increase in serum nitric oxide (nitrite/nitrate) level, the histological liver damage as well as the decrease in mucopolysaccharide and protein content of hepatocytes were all improved by Crataegus extract at 40 mg/kg and almost normalized by silymarin. These results suggest that treatment with Crataegus extract improves the CCl₄-induced hepatic injury in rats.

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Title: Effect of Crataegus extract on carbon tetrachloride-induced hepatic damage
Authors: Omar M. E. Abdel Salam
Amany A. Sleem
Nermeen Shafee
Publication date: 01-12-2012
Publisher: Springer-Verlag
Published in: Comparative Clinical Pathology / Issue 6/2012
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-011-1356-7

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Effect of Crataegus extract on carbon tetrachloride-induced hepatic damage

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