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BMC Women's Health
Published in: BMC Women's Health 1/2007

Open Access 01-12-2007 | Research article

Effect of cough technique and cryogen gas on temperatures achieved during simulated cryotherapy

Authors: Yancy Seamans, Charlie Loesel, Jose Jeronimo, John Sellors, Philip E Castle

Published in: BMC Women's Health | Issue 1/2007

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Abstract

Background

Cryotherapy is often used to treat cervical precancer in developing countries. There are different methods and cryogen gases used for cryotherapy, including the freeze-flush-freeze (cough) technique employed to minimize gas blockage. However, there is limited information to compare their effectiveness.

Methods

Using a tissue model, we compared temperature-time curves for four cryotherapy methods: uninterrupted freezing with nitrous oxide (N2O) and carbon dioxide (CO2), and two methods using a standard and extended version of the cough technique with CO2.

Results

Uninterrupted freezing with both N2O and CO2 produced tissue temperatures less than -20°C (-40°C and -30°C respectively). CO2 cryotherapy procedures using the two cough techniques produced temperatures greater than -20°C in the model tissue.

Conclusion

CO2 cryotherapy using the cough technique may not achieve sufficiently low temperatures to produce the desired therapeutic effect. Other alternatives to the prevention of gas blockage should be developed.
Appendix
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Literature
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Adewole IF, Babarinsa IA, Odeniyi GD: Cryotherapy in the management of cervical intraepithelial neoplasia in developing countries. Int J Gynaecol Obstet. 1998, 60: 69-70. 10.1016/S0020-7292(97)00222-1.CrossRefPubMed
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Seamans Y, Sellors J, Broekhuizen F, Howard M: Preliminary report of a gas conditioner to improve operational reliability of cryotherapy in developing countries. BMC Womens Health. 2006, 6:2.: 2-10.1186/1472-6874-6-2.CrossRef
Metadata
Title
Effect of cough technique and cryogen gas on temperatures achieved during simulated cryotherapy
Authors
Yancy Seamans
Charlie Loesel
Jose Jeronimo
John Sellors
Philip E Castle
Publication date
01-12-2007
Publisher
BioMed Central
Published in
BMC Women's Health / Issue 1/2007
Electronic ISSN: 1472-6874
DOI
https://doi.org/10.1186/1472-6874-7-16

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